Ozempic has gained a lot of publicity due to its success in the diabetes and weight loss space. In fact, due to a shortage of the drug in the US, this has forced many Americans to buy Ozempic online from Canadian pharmacies in order to fill their prescription. Though research has characterized its favorable safety and efficacy profile, it is important to understand the conditions under which Ozempic must be kept to achieve these results.

Ozempic pens have specific storage instructions, requiring careful temperature control with refrigeration for a certain period of time. It is essential to follow these storage instructions correctly to ensure you are getting the most out of your Ozempic. This article will discuss how to properly store Ozempic and how to troubleshoot certain storage concerns.

What is Ozempic?

Ozempic, also known by its generic name semaglutide, is a prescription medication. It is indicated for adults with type 2 diabetes to improve blood sugar adjunct to diet and exercise. Ozempic can also be used in individuals with type 2 diabetes and heart disease to lower one’s chances of cardiovascular events like stroke, heart attack, and death.

Recently, Ozempic has gained traction for its efficacy in supporting weight loss. Initial research shows that Ozempic may reduce body mass by 12 percent, increasing the general public’s interest in the drug during the obesity epidemic. However, it is important to note that Ozempic is not FDA-approved for weight loss, and it is not a replacement for lifestyle changes like eating a healthy diet and exercising regularly.

With the recent buzz around Ozempic, many may be wondering how to properly handle the medication. Ozempic has unique storage and administration instructions that must be followed for optimal safety and efficacy. The rest of this article will describe how to store Ozempic as well as how to troubleshoot potential storage issues and changes.

How is Ozempic provided by the pharmacy?

Ozempic pens are provided in several strengths and different cartons. Depending on the optimal dose selected for you by your prescriber, you will receive one of these three options at a strength that is suited to your medical needs. These strengths include:

  • A prefilled pen with 2 mg/1.5 mL or 2 mg/3 mL of semaglutide. This strength provides a dose of either 0.25 mg or 0.5 mg with each injection. Which dose you administer will depend on where you are at in treatment. The 0.25 mg dose is for treatment initiation, while the 0.5 mg dose is for maintenance
  • A prefilled pen with 4 mg/3 mL of semaglutide. With this strength, you receive a dose of 1 mg with each injection.
  • A prefilled pend with 8 mg/3 mL of semaglutide. With this strength, you receive a dose of 2 mg with each injection.

For those prescribed Ozempic, individuals administer Ozempic at their individualized dose once weekly on the same day as an injection under the skin. You should never share pens with anybody else and ensure you use a new needle with each injection.

The importance of properly storing medications

When it comes to using medication effectively for the best results, you must consider more than just the dosing and administration of the drug. It is equally important to ensure you are properly storing your medications. How and where you store your medicine can influence its efficacy, so making sure your medicine is stored properly is essential.

The storage instructions for your medications will depend on the individual medication itself. Later in this article, we will discuss how to properly store your Ozempic for optimal safety and efficacy.

Why do some medications need to be refrigerated?

Many, if not most, medications need to be stored at well-controlled room temperature. Some medicines, however, require more extreme temperatures. Certain medications must be kept at colder temperatures, either in the refrigerator or freezer. The purpose of using the fridge or freezer is to keep these medications stable, ensuring their efficacy. One such medication that is kept in the fridge is Ozempic.

How to properly store Ozempic

Before using an Ozempic pen for the first time, you should store your Ozempic in the refrigerator between the temperatures of 36 and 46 degrees Fahrenheit (or 2 to 8 degrees Celsius). You should never store Ozempic in the freezer or right next to the cooling machinery in the refrigerator.

After opening an Ozempic pen, you can keep the pen in the fridge at the same temperature as before or at controlled room temperature (59 to 86 degrees Fahrenheit or 15 to 30 degrees Celsius) for up to 56 days. Ensure that Ozempic is protected from sunlight and extremely high temperatures. These storage instructions are summarized in the table below.

Ozempic Storage Instructions
Before first useRefrigerated at 36°F to 46°F (2°C to 8°C)Until the expiration date is reached
After first useRoom temperature at 59°F to 86°F (15°C to 30°C) or refrigerated at 36°F to 46°F (2°C to 8°C)For up to 56 days

The best way to keep track of your medication’s expiration is to write the disposal date on your calendar (e.g., 56 days after first use). Make sure to dispose of any used Ozempic pen after 56 days, despite how you have been storing it or if there is medication left. Unused pens can be kept in the refrigerator until the expiration date, after which they should be thrown out.

Will Ozempic work if it is not refrigerated?

After first use, Ozempic will work if it is not refrigerated for up to 56 days at a well-controlled room temperature. This means that although it does not need to be refrigerated, it should be kept at a temperature of 59°F to 86°F (15°C to 30°C).

Frequently Asked Questions

What if my Ozempic is delivered warm?

If your Ozempic was delivered warm, such as with the ice packs melted, they may have been exposed to heat. In this scenario, reach out to your mail-order pharmacy to troubleshoot. You may need to get new Ozempic pens if they were exposed to extreme temperatures for an extended period of time. If you have ordered your Ozempic through Buy Canadian Insulin and your Ozempic was delivered warm, you can contact our customer support through email, contact page, or phone if you have any questions regarding your medication.

How do I know if Ozempic has gone bad?

The best way to know if Ozempic has gone bad is to keep track of how long it has been open after first use. If you have received Ozempic and are concerned it may not have been stored correctly, check for signs that it has gone bad. These include:

  • Changes to consistency. For example, check if the liquid has developed particles or started clumping.
  • Color changes. The liquid should not be cloudy or discolored.
  • Odor changes. If the medication smells bad or strange, it may not be good any longer.

If your Ozempic has been exposed to extreme heat, the packaging may feel warm and the ice packs may be melted.

How long can I leave my Ozempic outside of the fridge?

You can leave used Ozempic outside the fridge at well-controlled room temperatures for up to 56 days. Keep unused Ozempic pens in the fridge.

Can you freeze Ozempic?

Do not freeze Ozempic. Just like with extremely high temperatures, extremely low temperatures can break down the medication, making it unstable and ineffective. If you accidentally freeze your Ozempic, do not use it and throw it away.

What do I do with my Ozempic if I am traveling?

Traveling with medications can be a bit difficult when it comes to controlling temperatures. When flying with unused Ozempic, keep them in an insulated travel container to keep them cool. Make sure to avoid storing them directly on ice, which could cause them to freeze. Keep your Ozempic medication in your carry-on luggage and separate it from the rest of your luggage during security screening.

If you are traveling by car, you can also keep unused Ozempic in a travel case. Only keep the pens in the main part of the car, as other parts like the trunk may have more extreme temperatures. When you reach your destination, put unused pens in the refrigerator.

How do you properly dispose of Ozempic?

Ensure that you are following correct disposal instructions when it comes to throwing away your Ozempic. You should be placing your Ozempic pen and needle in specific, FDA-cleared sharps disposal containers. If you do not have one of these, put them in a container that is:

  • Constructed with heavy-duty plastic
  • Able to be tightly and firmly closed
  • Resistant to leaks
  • Labeled as containing hazardous waste
  • Stable and upright

Dispose of your Ozempic correctly and immediately upon final use.


It is essential to store and maintain your Ozempic properly for optimal results. This will ensure that you are properly managing your diabetes and heart disease to the best of the medication’s abilities. In summary, you should:

  • Keep your Ozempic refrigerated until the first use
  • Keep used Ozempic either in the fridge or at well-controlled room temperatures for up to 56 days
  • Dispose of used Ozempic after 56 days or unused Ozempic after the expiration date
  • Check for signs of extreme temperature exposure, such as changes to the liquid’s color and texture
  • Ensure proper storage conditions during travel


  1. https://www.drugs.com/medical-answers/ozempic-refrigerated-3542954/
  2. https://www.uchealth.org/today/wegovy-vs-ozempic-the-truth-about-new-weight-loss-drugs/
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209637lbl.pdf
  4. https://diabeticme.org/learning-center/health-guides/does-ozempic-need-to-be-refrigerated/
  5. https://www.goodrx.com/ozempic/does-ozempic-need-to-be-refrigerated