Did you know that every year approximately 15 million people around the world have a stroke?

Of that 15 million, almost 5 million of those individuals die, and the other 5 million1 become permanently disabled. Without question, strokes can be devastating, which is why it’s been ranked as a significant public health problem.

In addition to strokes, atrial fibrillation is another alarming health condition, with 59.7 million cases worldwide. On top of that, blood clots affect about 900,000 Americans annually and are especially concerning for pregnant women and individuals with cancer.

Naturally, many people are shocked by these numbers, which seem to increase as our population ages. Fortunately, though, there is hope. For instance, medications like Eliquis are prescribed to help reduce and prevent bad outcomes and improve one’s quality of life. Unfortunately, its less-than-affordable cost makes it difficult for patients to get access to their much-needed medication. So, is there a generic equivalent to Eliquis? Keep reading to find out how this medication works and how US patients can get access to cheaper Eliquis and its generic equivalent.

What Exactly Is Eliquis?

Eliquis, also known as apixaban, is a popular blood thinning medication used to reduce the risk of blood clots and strokes in patients with a common arrhythmia known as atrial fibrillation. Atrial fibrillation occurs when the heart, particularly the ventricular chambers, beats more quickly or irregularly than normal. This disorganized heart rhythm dramatically increases the risk of having a stroke. A-fib, particularly if it’s poorly controlled, can dramatically increase a person’s risk of death. One study estimates a four-fold increase in mortality likelihood for people with this diagnosis.

Eliquis is also occasionally prescribed to patients following hip or knee replacement to reduce the risk of deep vein thrombosis (DVT). These clots can be painful in the legs. However, the real danger of these clots is that they can break off and go to either the brain (potentially causing a stroke) or the lungs (resulting in a potential pulmonary embolism).

Research continues to be conducted on using Eliquis and similar drugs in patients following bariatric surgery. To date, a consensus has not emerged on if this is a productive and low-risk way to utilize the medication.

How Does Eliquis Work?

Eliquis is one of many anticoagulant medications approved by the Food and Drug Administration (FDA). However, the mechanism that Eliquis works through differs from those used by older-generation anticoagulants like Warfarin. The difference in these mechanisms also means that the side effects may be different or less than with Eliquis.

Drugs, like Warfarin, act to deplete functional Vitamin K stores in the body. Vitamin K is essential for the body’s ability to form clots. With less active Vitamin K in the body, the body will not be able to form clots as quickly, and this acts to thin the blood. However, there are risks associated with inducing a functional Vitamin K deficiency, such as raising the risk of osteoporosis and adverse cardiovascular events.

On the other hand, Eliquis works by disrupting Factor Xa in the clotting process. The clotting process in the human body is complex, and it involves both intrinsic and extrinsic pathways, incorporating a wide variety of factors. At the end of both pathways, the final step in the clotting process is converting Factor X into Factor Xa. Eliquis, a Factor Xa inhibitor, slows down the clotting process by disrupting the Factor Xa process.

Eliquis Side Effects

Even though Eliquis offers essential benefits to many patients, it’s important to recognize that certain side effects are associated with the drug, and some of these can be life-threatening.

The most significant side effect is an increased risk of bleeding. This can make it difficult to stop bleeding from even simple cuts and cause bleeding gums and nosebleeds, as well as blood loss in urine and stool. Because of this heightened risk of bleeding, patients usually need to stop Eliquis before any surgery or medical procedure. Patients should be carefully monitored for increased bleeding, and patients should also be educated about when they should seek out medical assistance for blood loss.

In addition to increased bleeding, Eliquis can also cause nausea in some patients, and it may impact liver function and liver enzymes. This may require careful and regular monitoring from one’s medical provider, including blood tests, such as complete metabolic panels.

Who Shouldn’t Take Eliquis?

Although Eliquis is an appropriate medication for most people and has fewer side effects than other anticoagulants15, this doesn’t mean it is the proper medication for everyone. Certain people should not use Eliquis. For example, Eliquis isn’t recommended for pregnant women or breastfeeding moms. It’s also not recommended for individuals with liver problems or anti-phospholipid syndrome.

In some cases, doctors will either not prescribe Eliquis to individuals with chronic kidney disease or will prescribe a reduced dose. Patients with chronic kidney disease should be carefully monitored to ensure their kidney function is not worsening while using Eliquis.

It is also important for patients to let their doctors know about any prescription medications, over-the-counter drugs, or supplements that they are taking since Eliquis can negatively interact with some medication16.

How Much Does Eliquis Cost?

Eliquis is a costly medication, with a 30-day supply generally costing more than $500, even with discount services like GoodRx. In fact, many major pharmaceutical chains currently list monthly prices in excess of $600.

This prices many potential consumers, especially older adults on a fixed income, out of using Eliquis. Although many insurance plans cover Eliquis, the co-pays, and deductibles can be cost-prohibitive. Not surprisingly, many people are looking for ways to get the benefits of Eliquis without these high financial costs.

So, Is There a Generic Equivalent to Eliquis?

The short answer to this question is yes. In 2019, the Food and Drug Administration (FDA) approved a generic version of Eliquis. At the time, the makers of Eliquis had a patent set to expire in February 2023 that prevented genetic alternatives19 from flooding the market. So it should be available now, right? Not so fast!

The makers of Eliquis, Bristol Myers Squibb, sued in court and had their patent protection extended to the spring of 2028. Until this patent expires, apixaban cannot be sold in the United States. Once this patent protection goes away, though, apixaban should be available for a fraction of the price of Eliquis.

Where to Buy Generic Eliquis Online From Canada?

If you’re like many people, you probably don’t want to wait until 2028 to get the generic version of Eliquis, so what are you to do? Your best bet would be to buy Eliquis online from a reputable Canadian Pharmacy.

Apixaban is much more affordable in Canada since there are laws regulating the cost of prescription drugs. As a result, consumers can get what they need without the cost being much of a barrier. So if you’re in the United States and want to SAVE UP TO 90% on medication, get access to affordable Eliquis or a cheaper generic equivalent (apixaban), and have it express shipped to your home – Buy Canadian Insulin can help!

Reference List

  1. https://www.emro.who.int/health-topics/stroke-cerebrovascular-accident/index.html#:~:text=Annually%2C%2015%20million%20people%20worldwide,burden%20on%20family%20and%20community.
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288566/#:~:text=3.3.-,Public%20Health%20Burden%20of%20Stroke,1%2C%204%2C%2016%5D.
  3. https://heart.bmj.com/content/107/7/516
  4. https://www.cdc.gov/ncbddd/dvt/infographic-impact.html#:~:text=As%20many%20as%20100%2C000%20people,just%20after%20having%20a%20baby.&text=a%20PE%20die%20without%20warning,cancer%20after%20the%20cancer%20itself.
  5. https://www.eliquis.bmscustomerconnect.com
  6. https://www.drugwatch.com/eliquis/#:~:text=Eliquis%20(apixaban)%20is%20a%20prescription,heartbeat%20known%20as%20atrial%20fibrillation
  7.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515763/
  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306259/#:~:text=Patients%20with%20AF%20demonstrated%20a,%25%20CI%203.56–3.78)
  9. ttps://www.sciencedirect.com/science/article/abs/pii/S1550728921006110
  10. https://www.fda.gov/news-events/press-announcements/fda-approves-first-generics-eliquis
  11. https://www.ncbi.nlm.nih.gov/books/NBK470313/#:~:text=Go%20to%3A-,Mechanism%20of%20Action,synthesis%20of%20active%20clotting%20factors
  12. https://www.ncbi.nlm.nih.gov/books/NBK536983/#:~:text=Vitamin%20K%20refers%20to%20a,increased%20risk%20of%20cardiovascular%20disease
  13. https://www.ncbi.nlm.nih.gov/books/NBK507910/
  14. https://my.clevelandclinic.org/health/treatments/24745-factor-xa-inhibitors
  15. https://www.drugs.com/medical-answers/top-6-eliquis-side-effects-you-depth-3573434/
  16. https://www.healthline.com/health/drugs/eliquis-interactions#health-interactions
  17. https://www.goodrx.com/eliquis?c=homepage-lander-sem-7&utm_campaign=127243741&utm_content=121594327845&utm_source=google&utm_medium=cpc&utm_term=kwd-335048775511&gclid=Cj0KCQjw4s-kBhDqARIsAN-ipH2mfK832p-vWDXh4IXIRzXgW9V-6XHeIbE4GYlsICKrdt2cqgUA6ccaAlKOEALw_wcB&gclsrc=aw.ds&ajs_prop_experiment_name=Next%2520Best%2520Action%2520on%2520SEM-7&ajs_prop_variation_name=Variation_1&ajs_prop_path=%2Fgo%2Fhomepage-lander-sem-7-tl
  18. https://www.fda.gov/news-events/press-announcements/fda-approves-first-generics-eliquis
  19. https://www.foxcarolina.com/2023/01/14/fda-approved-generic-version-eliquis-it-wont-be-available-several-years/
  20. https://news.bms.com/news/corporate-financial/2021/The-Bristol-Myers-Squibb-Pfizer-Alliance-is-pleased-with-the-decision-by-the-U.S.-Court-of-Appeals-for-the-Federal-Circuit-upholding-the-Eliquis-Patents/default.aspx