If you’re on a weight loss journey and looking for effective solutions, you’ve likely heard of Ozempic. Ozempic is a medication originally used to treat type 2 diabetes, but now hundreds of thousands of people, including celebrities and even those who don’t have diabetes, are turning to it for weight loss. In this article, we’ll explore how quickly you can expect to lose weight with Ozempic and what factors might influence your results. Whether you’re just starting your weight loss journey or looking for a new method to try, keep reading to see if Ozempic can help you reach your goals quickly.

Key Takeaways

  • Weight loss with Ozempic can take several weeks to start, with more noticeable changes often seen after about 8 weeks when the dosage is increased to 0.5 mg or higher.
  • In a clinical trial, participants lost an average of 14.9% of their body weight over 68 weeks, equating to about 34 pounds, with 85% losing at least 5% of their body weight.
  • Factors influencing weight loss speed include metabolism, diet, exercise, age, and overall health. Regular physical activity and a nutrient-rich diet enhance results.
  • Common side effects like nausea (up to 20% of users), vomiting (5-10%), and diarrhea (10-15%) can impact weight loss by affecting diet and comfort levels.
  • Long-term use of Ozempic is essential for maintaining weight loss, as stopping the medication can lead to regaining lost weight. An extension of the 68-week STEP program showed patients regained 11.6% of lost weight by week 120 after stopping.
  • If Ozempic isn’t working, consider evaluating the dosage, ensuring consistency in medication intake, and combining it with a healthy lifestyle, including diet and exercise, to improve effectiveness.

How Quickly Do You Lose Weight on Ozempic?

Generally, it can take several weeks before noticeable weight loss occurs. Ozempic medication works by slowing down the emptying of your stomach, which helps you feel fuller for longer periods and can reduce your overall calorie intake. However, weight loss typically doesn’t happen immediately after starting the medication.

During the initial phase, you begin with a low dose of Ozempic, usually 0.25 mg weekly, for the first four weeks. This low dose helps your body adjust to the medication and minimizes potential side effects such as nausea and stomach discomfort. Some people may notice minor weight loss during this period, but for most, significant changes will appear only after the dosage is gradually increased.

After the first four weeks, the dose is increased to 0.5 mg weekly. This process of slowly ramping up the dosage continues over the next few months until you reach the maintenance dose of up to 2 mg weekly. People usually begin to see more substantial weight loss around the eight-week mark, or even later.

The timing can vary from person to person. Factors such as your metabolism, dietary habits, level of physical activity, age, and overall health can influence how quickly you lose weight on Ozempic. Some people may start seeing weight loss earlier, while others might take longer. It is essential to be patient and consistent with your medication and lifestyle changes to achieve the best results.

How Much Weight Will I Lose With Ozempic?

A woman standing on a weighing scale with her hands up

Clinical trials provide useful insights for setting expectations about weight loss with Ozempic. A significant clinical trial from 2021 showed that people with obesity who took semaglutide (the active ingredient in Ozempic) at a dose of 2.4 mg lost an average of 14.9% of their body weight over 68 weeks. This result was achieved when combined with lifestyle interventions like a balanced diet and regular exercise. On average, participants lost about 34 pounds during the trial. In comparison, those in the placebo group lost only 2.4% of their body weight, or about 5.7 pounds.

Further breaking down the results:

  • Over 85% of participants lost at least 5% of their body weight.
  • Around 70% lost at least 10% of their body weight.
  • Approximately 50% lost at least 15% of their body weight.
  • About 33% lost at least 20% of their body weight.

These results highlight the significant potential for weight loss with Ozempic when combined with lifestyle changes. Another trial comparing semaglutide with liraglutide (another weight loss medication) found that those taking semaglutide lost 15.8% of their body weight after 68 weeks, while those on liraglutide lost 6.4%.

What Factors Influence the Speed of Weight Loss on Ozempic?

vegetables, measuring tape and ozempic pen on a white surface


Nutrition is crucial in how quickly you can lose weight while taking Ozempic. In the same study, participants who adhered to a nutrient-rich, balanced diet experienced better results. A balanced diet means eating various foods that provide essential nutrients, including fruits, vegetables, lean proteins, and whole grains. Consuming fewer calories than you burn is necessary for weight loss.


Regular physical activity is another key factor in achieving effective weight loss with Ozempic. The clinical trials on semaglutide required participants to engage in at least 150 minutes of moderate-intensity aerobic activity per week, along with two days of resistance training. This level of physical activity helps increase calorie burn, build muscle mass, and improve overall health. According to studies, those who maintained this exercise routine while taking semaglutide achieved significant weight loss.

Sleep and Stress

Sleep and stress management significantly influence the success of weight loss in Ozempic. Poor sleep quality and high-stress levels can hinder weight loss by affecting hormone levels. Elevated cortisol, the stress hormone, can increase cravings for unhealthy foods and make it harder to stick to a diet. Research indicates that individuals with consistent sleep schedules, high-quality sleep, and sufficient sleep duration lose more weight. For instance, studies have shown that better sleep quality and longer sleep duration are associated with greater weight loss success. Additionally, untreated sleep conditions like sleep apnea can further impede weight loss efforts.

Medical History

Your medical history can also impact how effectively Ozempic helps you lose weight. Certain medical conditions, such as hypothyroidism or polycystic ovarian syndrome (PCOS), can make weight loss more challenging. Medications that contribute to weight gain can also affect your results. According to a study, people on higher doses of semaglutide lost more weight than those on lower doses.


The dosage of Ozempic you take influences how quickly you lose weight. Initially, you start on the lowest dose to allow your body to adjust and minimize side effects. This dose is gradually increased until you reach a maintenance dose that effectively supports weight loss. Some people may begin losing weight on the lower doses, while others may need higher doses for significant results.

Benefits of Losing Weight While Taking Ozempic

Man injecting Ozempic into his stomach

Losing weight while taking Ozempic can significantly improve overall health and reduce the risk of various diseases and conditions associated with being overweight or obese. Here are the key benefits:

  • Lower Blood Pressure: Weight loss can help reduce high blood pressure, decreasing the risk of heart disease and stroke.
  • Improved Cholesterol Levels: Weight loss can lead to better cholesterol profiles, including lower LDL cholesterol and higher HDL cholesterol.
  • Reduced Blood Sugar Levels: Ozempic helps improve blood sugar control, which is beneficial for managing type 2 diabetes.
  • Lower Risk of Heart Disease: Weight loss can reduce the risk of heart disease by improving cardiovascular health.
  • Reduced Risk of Stroke: By lowering blood pressure and improving heart health, weight loss can decrease the risk of stroke.
  • Improved Gallbladder Health: Weight loss can reduce the risk of gallbladder disease.
  • Relief from Osteoarthritis: Weight loss can alleviate the pressure on joints, reducing the symptoms of osteoarthritis.
  • Better Sleep Quality: Weight loss can improve sleep quality by reducing the severity of sleep apnea.
  • Reduced Cancer Risk: Weight loss can lower the risk of various cancers associated with obesity.
  • Improved Mental Health: Weight loss can reduce the incidence of mental illnesses like depression and anxiety.

Can Ozempic Be Taken Long-Term?

Ozempic can be used long-term for weight loss. People typically stay on Ozempic as long as it continues to work for them and they do not experience significant side effects. Long-term use is essential because obesity is considered a chronic condition, similar to diabetes or high blood pressure, which requires ongoing management. Studies have shown that continuous use of Ozempic helps maintain weight loss and manage blood sugar levels.

Can You Regain Weight After Using Ozempic?

When you stop taking Ozempic, it’s possible to regain the weight you lost. Without the medication, the effects of making you feel fuller for longer wear off, and your appetite may return to its previous levels.

An extension of the 68-week STEP program showed that patients who stopped taking semaglutide regained about 11.6% of their lost weight by week 120 (about 28 months). This means that, while they initially lost a significant amount of weight, stopping the medication led to weight regain. Overall, their net weight loss over 120 weeks was only 5.6%.

Additionally, any improvements in blood sugar control or reductions in the risk of cardiovascular diseases achieved while on Ozempic may also reverse upon discontinuation of the medication.

Is it Possible to Keep Weight Off After Ozempic?

Yes. It is possible to keep the weight off after stopping Ozempic, but it requires a consistent and disciplined approach to lifestyle changes. Maintaining weight loss typically involves continuing with a reduced-calorie diet, regular physical activity, and other healthy habits adopted during the weight loss journey with Ozempic.

While Ozempic helps manage weight by controlling appetite and blood sugar, continuing these lifestyle changes without the medication is crucial for long-term success. If you discontinue Ozempic because of side effects, there are other weight loss medications available that might be suitable alternatives. These include Saxenda (liraglutide), Zepbound (tirzepatide), Adipex (phentermine), and Qsymia (phentermine/topiramate).

How to Know if Ozempic Isn’t Working?

If you are not seeing any progress in your weight loss goals while taking Ozempic, it might indicate that the medication is not working as effectively for you. Some signs include:

  • No Weight Loss After Several Weeks: Most people begin to see some weight loss after eight weeks of taking Ozempic. If you have been on the medication for this long and haven’t noticed any changes, it might not be working well for you.
  • Plateau in Weight Loss: If you initially lost weight but have now reached a point where your weight has remained the same for several weeks, it could be a sign that Ozempic’s effectiveness is tapering off.
  • No Improvement in Appetite Control: If you don’t feel any difference in your appetite or still experience frequent hunger, the medication may not be effective for you.
  • Persistent Side Effects: Experiencing ongoing severe side effects like nausea, vomiting, or stomach pain without seeing any weight loss benefits can indicate that the current dosage or medication may not be suitable for you.

If Ozempic is not working for you, there are several adjustments and steps you can take to potentially improve its effectiveness:

  • Evaluate Your Dosage: Sometimes, the initial lower doses of Ozempic may not be sufficient for significant weight loss. The starting dose is typically 0.25 mg per week, which is gradually increased. If you haven’t reached the maintenance dose (which can be up to 2 mg weekly), discuss increasing your dosage. This gradual increase helps minimize side effects and allows your body to adjust.
  • Check Your Lifestyle Habits: Ensure that you are combining Ozempic with healthy lifestyle habits. This includes following a balanced diet, engaging in regular physical activity, managing stress, and getting adequate sleep. These factors can significantly enhance the effectiveness of the medication.
  • Consistency: Make sure you are taking Ozempic consistently and as directed. Missing doses or not following the prescribed regimen can impact the medication’s effectiveness.
  • Monitor and Record Progress: Keep track of your weight, dietary habits, physical activity, and any side effects. This record can help identify patterns or factors that might be influencing the effectiveness of Ozempic.

Final Thoughts

Ozempic can be a powerful tool for weight loss, especially when combined with healthy lifestyle changes. It’s important to be patient, as significant weight loss often begins after a few weeks of treatment. Consistency with the medication and maintaining good dietary and exercise habits are key to achieving and sustaining your weight loss goals. If you find Ozempic isn’t working as expected, consider evaluating your dosage or lifestyle habits, and keep track of your progress to identify any areas for improvement.

FAQs About Ozempic and Weight Loss

How long does it take for Ozempic to start working?

Ozempic typically starts lowering blood sugar levels within the first week of use at the regular maintenance dose. However, it may take about 4 to 8 weeks to see the full effects. During the initial period, the medication needs time to build up in your system and reach a steady state. This period allows your body to adjust to the medication, which helps in reducing side effects and improving overall effectiveness.

How much weight can you lose in a month on Ozempic?

Research suggests that people can lose an average of 5 pounds monthly on Ozempic. However, the amount of weight you can lose in a month with Ozempic depends on factors such as your dose, starting weight, diet, exercise, and other medications.

How much weight can you lose on Ozempic in 3 months?

In a clinical trial with 175 patients, the average weight loss was about 15 pounds over three months. This translates to approximately 5 pounds per month if there’s a steady state of weight loss.

How to speed up weight loss on Ozempic?

To speed up weight loss on Ozempic, combine it with a healthy diet and regular exercise. Staying hydrated and getting enough sleep can also help.

Does Ozempic target belly fat?

Ozempic can help reduce overall body fat, including belly fat, by decreasing appetite and improving how the body uses insulin.

Why am I still hungry on Ozempic?

Feeling hungry on Ozempic can happen if your diet isn’t balanced or if your body is still adjusting to the medication. Eating more protein, fiber, and healthy fats can help keep you full longer.

Can a non-diabetic take Ozempic for weight loss?

Yes, Ozempic can be taken as an off-label for weight loss in non-diabetic individuals, however, it is typically used under medical supervision for those with obesity or overweight-related health issues.

Who should avoid taking Ozempic?

Individuals with a history of pancreas or kidney problems, diabetic retinopathy, certain types of thyroid cancer, or those who are pregnant or breastfeeding should avoid taking Ozempic. Consult with your doctor for personalized advice.

Why am I gaining weight on Ozempic?

Weight gain on Ozempic can result from multiple factors including insufficient sleep, high stress, poor diet, lack of exercise, or underlying health conditions.

What happens if I overeat while on Ozempic?

Overeating while taking Ozempic can exacerbate side effects like stomach pain, diarrhea, constipation, nausea, and vomiting.


New England Journal of Medicine. (2021). Once-weekly semaglutide in adults with overweight or obesity. Retrieved June 24, 2024, from https://www.nejm.org/doi/10.1056/NEJMoa2032183

National Center for Biotechnology Information. (n.d.). Weight loss outcomes associated with semaglutide treatment for patients with overweight or obesity. PubMed Central. Retrieved June 24, 2024, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486455/

Wilding, J. P. H. (2022). Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension. Diabetes, Obesity and Metabolism. Wiley Online Library. https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.14725