Living with Type 2 diabetes requires constant monitoring of blood sugar levels to prevent potential health complications. Jardiance and Metformin are two common medications used to treat type 2 diabetes. However, selecting the appropriate medication can be a challenging task since not all diabetes medications function the same way for everyone.

Some individuals may experience side effects, while others may not accomplish their desired blood sugar levels with a specific medication. This can be frustrating and make diabetes management even more difficult.

In this article, you will understand type 2 diabetes and the significant differences between Jardiance and Metformin. We will cover how these medications work, their benefits in treating type 2 diabetes, and the potential side effects. Additionally, we’ll explore which medication might be more effective for specific types of patients.

So, let’s get started!

Key Takeaways

  • Jardiance and Metformin are two common medications used to treat Type 2 Diabetes, but not all diabetes medications function the same way for everyone.
  • Jardiance (Empagliflozin) has been shown to reduce A1C levels by an average of 0.5% to 1%. In contrast, Metformin can reduce A1C levels by approximately 1.5% to 2% in most patients as a first-line therapy for Type 2 Diabetes.
  • Patients on Jardiance may experience weight loss, averaging 2-3% of their body weight, as it helps excrete glucose through urine. In contrast, Metformin may lead to slight weight loss or weight neutrality, which is beneficial for overweight or obese patients.
  • Jardiance has demonstrated a 38% reduction in cardiovascular mortality in patients with Type 2 Diabetes, making it a preferred option for patients with existing heart disease or at high risk of cardiovascular events.
  • Metformin is generally well-tolerated but may cause gastrointestinal side effects in about 25% of patients. Jardiance’s side effects include a higher risk of genital infections, reported in about 5-10% of patients, but it has a lower risk of causing hypoglycemia compared to other diabetes medications.
  • Metformin is usually more affordable and widely covered by insurance plans than Jardiance, which might be more expensive and subject to insurance restrictions or prior authorization.
  • Metformin is typically recommended as the first-line treatment for most patients with Type 2 Diabetes due to its proven effectiveness, safety profile, and cost. Jardiance is often considered for patients who have specific cardiovascular risks or those who cannot tolerate Metformin.

Jardiance (Empagliflozin Tablets)What is Jardiance (Empagliflozin)?

Jardiance (Empagliflozin) is a prescription medication used to manage blood sugar levels in adults with Type 2 Diabetes Mellitus. It belongs to a class of drugs known as sodium-glucose co-transporter 2 (SGLT2) inhibitors. SGLT2 is a protein in the kidneys that reabsorbs glucose back into the bloodstream. By inhibiting this protein, Jardiance helps the body excrete excess glucose through urine, lowering blood sugar levels in adults with Type 2 Diabetes.

The way Jardiance works in the body involves blocking the action of SGLT2. This inhibition decreases blood glucose levels as the kidneys excrete more glucose through urine rather than reabsorbing it into the bloodstream. This mechanism not only helps in improving glycemic control but also offers benefits beyond blood sugar management.

The benefits of using Jardiance for Type 2 Diabetes include:

  • Improved Glycemic Control: Jardiance effectively lowers blood sugar levels, which is crucial in managing Type 2 Diabetes and reducing the risk of diabetes-related complications.
  • Cardiovascular Benefits: Clinical trials have shown that Jardiance can reduce the risk of cardiovascular death in adults with Type 2 Diabetes who have established cardiovascular disease. It’s also beneficial in reducing the risk of hospitalization for heart failure in adults with heart failure.
  • Weight Management: Treatment with Jardiance may lead to weight loss, which is a beneficial side effect for many patients with Type 2 Diabetes who are overweight or obese.
  • Blood Pressure Reduction: Jardiance has been observed to lower blood pressure in some patients, which is beneficial for those with Type 2 Diabetes, as high blood pressure is a common comorbidity.

What is Metformin?

Metformin Box

Besides its primary indication for type 2 diabetes, metformin has off-label uses for managing gestational diabetes, addressing weight gain issues caused by antipsychotic medications, preventing type 2 diabetes, and treating and preventing polycystic ovary syndrome (PCOS).

According to a study, Metformin is currently the only antidiabetic medication recommended by the American Diabetes Association (ADA) for prediabetes. Metformin has multiple ways of functioning to improve glucose tolerance and decrease basal and postprandial plasma glucose levels. It reduces the amount of glucose the liver produces, lowering fasting glucose levels. Additionally, it impacts the gut, reducing glucose absorption into the bloodstream after meals.

Metformin also enhances peripheral glucose uptake and utilization by increasing insulin sensitivity. Doing so helps lower blood glucose levels without increasing insulin secretion, which can lead to hypoglycemia, a condition of low blood sugar levels associated with other diabetes medications.

The benefits of using Metformin for managing Type 2 Diabetes include:

  • First-line Treatment: Metformin is considered the preferred first-line therapy for type 2 diabetes in adults and pediatric patients aged 10 or older.
  • Weight Management: It is recognized as weight-neutral, with the potential to induce modest weight loss, which is particularly beneficial for overweight or obese patients.
  • Low Risk of Hypoglycemia: Metformin is unlikely to cause hypoglycemia (low blood sugar levels) when used alone.
  • Cardioprotective Effects: It may lower the risk of cardiovascular events and mortality, offering additional health benefits beyond glucose control.
  • Improvement in Insulin Sensitivity: By enhancing insulin sensitivity, metformin helps improve the effectiveness of insulin in the body, reducing the need for excessive insulin production.

Comparing Jardiance and Metformin

The following is a comparative analysis of two commonly used medications: Jardiance and Metformin. This analysis aims to provide a comprehensive understanding of the similarities and differences between the two drugs in terms of their side effects, efficacy, and cost.

Side Effects of Jardiance and Metformin

Jardiance

Metformin

Common Side Effects

The most common side effects reported in clinical trials include:

  • Urinary tract infections: These were reported in 9.3% of patients taking 10 mg of Jardiance and 7.6% of those taking 25 mg, compared to 7.6% of those on placebo.
  • Female genital mycotic infections: Female patients experienced genital mycotic infections in 5.4% of cases with Jardiance 10 mg and 6.4% with Jardiance 25 mg, compared to 1.5% with a placebo.
  • Increased urination: For patients taking Jardiance, 10mg or 25mg, increased urination affects 3.4% and 3.2%, respectively.
  • Thirst: Thirst occurred in 1.7% of patients taking 10 mg of Jardiance and 1.5% taking 25 mg of Jardiance.

These side effects were generally mild to moderate in intensity and were more common in patients treated with Jardiance than with a placebo.

Serious Side Effects

Serious side effects associated with Jardiance include:

  • Ketoacidosis: A serious condition that may require hospitalization, characterized by increased ketones in your blood or urine. Patients need to be assessed for ketoacidosis symptoms regardless of blood glucose level.
  • Volume Depletion: Symptoms like dizziness, fainting, and low blood pressure may occur, especially in patients with renal impairment or elderly.
  • Urosepsis and Pyelonephritis: Serious urinary tract infections requiring hospitalization.
  • Hypoglycemia: Especially when taken with other diabetes medications like insulin or sulfonylurea.
  • Necrotizing Fasciitis of the Perineum (Fournier’s Gangrene): A rare but serious bacterial infection that causes damage to the tissue under the skin in the area between and around the anus and genitals.

Common Side Effects

The following have been reported as the most common side effects of metformin:

  • Gastrointestinal (GI) effects: These include diarrhea, nausea, and vomiting. These side effects are relatively common, affecting up to 30% of Metformin patients. It’s worth noting that GI effects are the most frequently reported adverse reactions to Metformin use.

Serious Side Effects

  • Lactic Acidosis: This is an infrequent yet severe adverse effect with an incidence rate of approximately 1 in 30,000 patients. Symptoms include malaise, respiratory distress, elevated lactate levels, and anion gap acidosis. It is a medical emergency and can lead to severe consequences such as hypotension, hypothermia, and even death if not treated promptly.

Efficacy in Lowering Blood Sugar

Jardiance

Metformin

Jardiance has been evaluated for its effectiveness in lowering blood sugar levels in adults with type 2 diabetes through several clinical studies. In a monotherapy study involving 986 patients, Jardiance demonstrated significant reductions in HbA1c levels compared to placebo. When combined with metformin in a study of 637 patients, 10 mg and 25 mg of Jardiance significantly reduced HbA1c, fasting plasma glucose (FPG), and body weight.

Similar outcomes were observed in a study of 666 patients treated with Jardiance in combination with metformin and sulfonylurea. An active-controlled study comparing Jardiance 25 mg to glimepiride in 1545 patients as an add-on therapy to metformin showed comparable reductions in HbA1c and FPG, with Jardiance also leading to significant weight loss.

Overall, Jardiance has proven to be an effective treatment option for improving glycemic control in adults with type 2 diabetes mellitus, showcasing its ability to significantly lower blood sugar levels and contribute to weight loss in various study settings.

According to a study, Metformin is an effective medication for lowering blood sugar levels. It works through various mechanisms of action, including enhancing insulin sensitivity, reducing gluconeogenesis, and facilitating glucose uptake by muscles without increasing insulin secretion. This makes it unique among hypoglycemic agents like insulin, glibenclamide, and chlorpropamide.

One significant study, the UK Prospective Diabetes Study (UKPDS 34), reported that treating diabetes with metformin is associated with a 30% reduction in diabetes-related mortality and complications. This highlights the effectiveness of metformin in regulating blood sugar and reducing the risk of diabetic complications, making it a cornerstone in managing type 2 diabetes mellitus.

Furthermore, metformin has been found to reduce the incidence of type 2 diabetes by 31% over three years compared to placebo, making it a promising option for pre-diabetes management.

Cost

Jardiance

Metformin

Jardiance (empagliflozin) costs $2.6177 per day and $1,139.33 per year, without additional fees or markups.A metformin extended-release oral solution costs $635 per bottle (about 480 mL. For a daily dose of 1,000 mg (10 mL), the cost is $13.23 per day or $396.88 per month. The immediate-release oral solution of metformin at the same dosage is expected to cost approximately $10.25 per day. Additionally, 1,000-mg immediate-release metformin tablets usually cost less than $1.00 daily.

Recommendation

Jardiance is a highly recommended medication for effectively managing type 2 diabetes. It has been proven to lower HbA1c levels and diminish cardiovascular risks. You can purchase a 30-tablet supply of 10mg strength for only $139.00 through Buy Canadian Insulin, which offers substantial cost savings compared to US prices. This makes it accessible and affordable for individuals seeking dependable diabetes medication. Additionally, Jardiance from Canada offers a seamless experience with convenient online ordering and dependable express shipping for users aiming for optimal blood sugar management.

Jardiance and Metformin: Which Medication Works Best for Type 2 Diabetes?

Both Jardiance and Metformin are effective medications for managing type 2 diabetes, but they work in different ways. Jardiance helps lower blood sugar by increasing glucose excretion through urine and also has benefits for heart health, reducing the risk of cardiovascular events. Metformin, on the other hand, decreases glucose production in the liver and improves the body’s sensitivity to insulin, making it easier for cells to use glucose. Jardiance can lead to side effects like urinary tract infections and dehydration, while Metformin commonly causes gastrointestinal issues such as nausea and diarrhea. In terms of cost, Metformin is generally more affordable compared to Jardiance. The best choice depends on individual factors, including how the body responds to each medication and any additional health benefits required.

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FAQs On Jardiance and Metformin

Can you take Jardiance and Metformin together?

Yes, Jardiance (Empagliflozin) and Metformin can be taken together. This combination is often prescribed to manage blood sugar levels in individuals with type 2 diabetes. Jardiance helps reduce glucose reabsorption in the kidneys, while Metformin decreases glucose production in the liver and improves insulin sensitivity.

What is the best time to take Jardiance and Metformin?

Jardiance is usually taken once daily in the morning, with or without food. Metformin should be taken with meals to reduce gastrointestinal side effects. It’s best to follow the specific instructions provided on the medication packaging.

Can you take Metformin, Glipizide, and Jardiance together?

Yes, it is possible to take Metformin, Glipizide, and Jardiance together. Each medication works differently to control blood sugar levels. However, combining these medications can increase the risk of hypoglycemia (low blood sugar), so monitoring and dose adjustments might be necessary.

Does the Jardiance and Metformin combination cause weight loss?

Yes, the combination of Jardiance and Metformin may lead to weight loss in some individuals. Jardiance can promote weight loss by increasing glucose excretion through urine, while Metformin can reduce appetite. However, the extent of weight loss can vary among individuals.

What is the half-life of Jardiance?

The half-life of Jardiance is 12.4 hours.

What is the half-life of Metformin?

The half-life of Metformin is 4.5 hours.

What should I avoid while taking Jardiance?

There are no specific dietary restrictions while taking Jardiance. It is important to maintain a healthy diet and stay well-hydrated.

Can Jardiance help if I have kidney disease?

Yes, studies show Jardiance can slow down kidney problems from getting worse and lower the risk of heart disease-related death in people with chronic kidney disease (CKD).

Is there a generic version of metformin?

Yes, there is a generic version of metformin available. Metformin is commonly sold under the brand names Glucophage and Glumetza, but its generic form is widely available and often more affordable.

Is there a generic version of Jardiance?

No, there is no generic version of Jardiance available. Jardiance is still under patent protection, so only the brand-name version is available for purchase.

Sources

  • Corcoran, C., & Jacobs, T. F. (2023). Metformin. StatPearls Publishing. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK518983/
  • Boehringer Ingelheim International GmbH. (2022). JARDIANCE (empagliflozin tablets) prescribing information. https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/204629s033lbl.pdf
  • Neumiller, J. J. (2014). Empagliflozin: A new sodium-glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079288/
  • National Center for Biotechnology Information. Manufacturer’s Cost Analysis – Pharmacoeconomic Review Report: Empagliflozin. In Pharmacoeconomic Review Report: Empagliflozin (Jardiance). Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK533799/table/pe.app3.tab2/
  • Satterwhite, L. E. (2021). Metformin Extended-Release Oral Solution. Clinical Diabetes, 39(2), 226–227.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061547/