Type 2 diabetes is a chronic disease that affects 462 million people worldwide. It is characterized by high levels of blood sugar, which can lead to a range of complications, including heart disease, kidney failure, and blindness. 

Managing type 2 diabetes is a long-term commitment that often involves medication to maintain stable blood sugar levels and avoid serious health complications. With various medications available, deciding which suits your needs can be challenging. 

Fortunately, effective treatments, including medications like Jardiance and Ozempic, are available to manage this condition. While both drugs work to lower blood sugar levels, they have different mechanisms of action and side effects. Understanding the differences between Jardiance and Ozempic can help patients and healthcare providers make informed decisions about which medication to use.

In this article, we’ll provide clear, easy-to-understand information about Jardiance and Ozempic. We’ll cover how each medication works, its benefits, and the side effects you might experience. Whether you are newly diagnosed or looking to switch medications, we’ve got you covered. 

So, let’s get started!

Key Takeaways

  • Jardiance and Ozempic have different mechanisms for managing diabetes. Jardiance is an SGLT2 inhibitor, while Ozempic is a GLP-1 receptor agonist. Understanding these mechanisms can help in selecting the most appropriate medication.
  • Both medications have effectively lowered blood sugar levels, but individual responses may vary. Factors such as comorbidities and medication adherence can influence efficacy.
  • While both drugs are generally well-tolerated, they may cause different side effects. Jardiance is associated with an increased risk of urinary tract and genital infections. In contrast, Ozempic may lead to gastrointestinal issues like nausea and diarrhea.
  • Jardiance has shown cardiovascular benefits, reducing the risk of heart failure and cardiovascular death, which may be a crucial factor for individuals with diabetes and cardiovascular concerns.
  • Consideration of administration methods is vital. Jardiance is typically taken orally, while Ozempic is administered via injection. Preferences regarding administration routes can impact medication adherence.
  • Affordability and insurance coverage are significant considerations. While both medications may be effective, their costs and availability through insurance plans can vary, influencing the decision-making process for patients and healthcare providers.

Understanding Jardiance vs Ozempic

Let’s look closely at Jardiance and Ozempic to understand how these medications work and their specific indications.

Jardiance

Jardiance (empagliflozin) is a medication approved by the U.S. Food and Drug Administration (FDA) for treating type 2 diabetes mellitus. It has been granted a new indication to reduce the risk of cardiovascular death in adult patients with type 2 diabetes mellitus and cardiovascular disease.

Jardiance belongs to a class of medications known as sodium-glucose co-transporter 2 (SGLT2) inhibitors. These medications work by blocking the action of SGLT2, a protein responsible for reabsorbing glucose in the kidneys. By inhibiting this protein, empagliflozin promotes glucose excretion through the urine, lowering blood sugar levels in individuals with type 2 diabetes.

Ozempic

Ozempic (semaglutide) is an injectable prescription medicine indicated for adults with type 2 diabetes mellitus. It is used as an adjunct to diet and exercise to improve glycemic control. Ozempic is a glucagon-like peptide-1 (GLP-1) receptor agonist. GLP-1 is a hormone released naturally in the body in response to food intake. 

It regulates blood sugar levels by stimulating insulin release from the pancreas when blood sugar levels are high and decreasing glucagon secretion (a hormone that increases blood sugar levels). Additionally, GLP-1 slows gastric emptying, which can help reduce postprandial (after-meal) blood sugar spikes.

Efficacy

In the following section, we’ll examine the effectiveness of these two drugs in detail, supported by clinical trials.

Jardiance

Jardiance has demonstrated efficacy in treating type 2 diabetes. Clinical studies have shown that Jardiance effectively improves blood sugar control in adults with type 2 diabetes, as indicated by reductions in hemoglobin A1c (HbA1c) levels by 0.7 percent to 0.8 percent after 24 weeks of treatment. Additionally, fasting blood sugar levels were lowered by 19 mg/dL to 25 mg/dL, and there was a reduction in body weight by 2.8 percent to 3.2 percent from baseline. These results suggest that Jardiance is effective as monotherapy and combined with other diabetes medications, such as:

Moreover, Jardiance has been shown to reduce the risk of cardiovascular death by 38 percent in people with both type 2 diabetes and heart disease over three years when used in combination with other treatments for diabetes and heart disease. Therefore, Jardiance offers comprehensive benefits in managing type 2 diabetes by improving glycemic control and reducing cardiovascular risks.

Ozempic

Ozempic, like Jardiance, has proven to be a very effective treatment for type 2 diabetes. Studies have shown that Ozempic can significantly help control blood sugar levels. For people who are just starting treatment for their diabetes (first-line therapy), taking Ozempic led to a notable decrease in their A1C levels—a test that measures average blood sugar levels over the past 3 months—by about 1.45% to 1.55% more than those who didn’t take it. This significant reduction shows that Ozempic can make a real difference in managing diabetes from the start.

For patients who had already tried other treatments (second or third-line therapy), Ozempic continued to show benefits. Both low and high doses of Ozempic resulted in meaningful drops in A1C levels, ranging from -1.09% to -1.41%. This means that Ozempic can help lower blood sugar levels even after other treatments.

In another study where Ozempic was either the first or second treatment tried, patients saw even more impressive reductions in their A1C levels, between -1.9% and -2.2%, when compared to those on standard insulin therapy. This indicates that Ozempic is effective as an initial treatment and can also be a strong option if the first treatment isn’t enough.

Overall, Ozempic has shown to be a powerful tool in the fight against type 2 diabetes, offering significant help in lowering blood sugar levels, whether it’s used at the beginning of treatment or after trying other options.

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Side Effects

According to FDA prescribing information, Jardiance and Ozempic may produce several side effects. The following are the potential adverse reactions associated with the use of Jardiance and Ozempic:

Jardiance

Below are the following side effects associated with Jardiance:

  • Urinary Tract Infections

Urinary tract infections can be a serious concern for anyone. Jardiance has been known to increase the risk of such infections. If you experience painful or frequent urination, it’s essential to seek medical attention. Patients with a history of chronic or recurrent urinary tract infections are at a higher risk of developing a urinary tract infection. 

However, the treatment discontinuation rate due to urinary tract infections is relatively low at 0.1%, 0.2%, and 0.1% for placebo, Jardiance 10 mg, and Jardiance 25 mg, respectively. It’s interesting to note that urinary tract infections tend to occur more frequently in female patients. 

In fact, the incidence of urinary tract infections in female patients randomized to placebo, Jardiance 10 mg, and Jardiance 25 mg was 16.6%, 18.4%, and 17.0%, respectively. On the other hand, the incidence of urinary tract infections in male patients randomized to placebo, Jardiance 10 mg, and Jardiance 25 mg was 3.2%, 3.6%, and 4.1%, respectively.

  • Genital Mycotic Infections

Jardiance may also increase the risk of genital mycotic infections, particularly in females. This can lead to discomfort, itching, and abnormal discharge in the genital area. In clinical trials, the incidence of genital mycotic infections was found to be higher in patients treated with Jardiance compared to those who received a placebo. 

Specifically, 0.9%, 4.1%, and 3.7% of patients randomized to placebo, Jardiance 10 mg, and Jardiance 25 mg, respectively, experienced genital mycotic infections. However, it is worth noting that discontinuation from the study due to genital infection occurred in only 0.2% of patients treated with either Jardiance 10 or 25 mg, and in none of the placebo-treated patients.

  • Volume Depletion

Jardiance may cause low blood pressure, especially in dehydrated patients. To minimize the risk, patients are advised to maintain adequate fluid intake. In clinical trials, adverse reactions related to volume depletion, such as:

  • Decreased blood pressure
  • Dehydration
  • Hypotension
  • Hypovolemia
  • Orthostatic hypotension
  • Syncope

These reactions were reported in a small percentage of patients. Specifically, 0.3%, 0.5%, and 0.3% of patients treated with a placebo, Jardiance 10 mg, and Jardiance 25 mg reported these adverse reactions, respectively. Patients at risk of volume contraction may have an increased risk of hypotension when taking Jardiance.

  • Ketoacidosis

Jardiance, while a relatively safe medication, has been linked with a rare but serious condition called ketoacidosis. This condition is characterized by high levels of ketones in the blood and can occur even if your blood sugar levels are below 250 mg/dL. It is important to note that if you experience symptoms of ketoacidosis while taking Jardiance, you must stop taking the medication immediately and seek medical attention. Symptoms of ketoacidosis include:

  • Frequent urination
  • Excessive thirst
  • Dry mouth
  • Abdominal pain
  • Nausea and vomiting
  • Shortness of breath
  • Confusion
  • Fatigue
  • Hypersensitivity Reactions

Some individuals may experience allergic reactions to Jardiance, which can manifest as swelling of the face, lips, throat, and other areas of the skin, along with difficulty breathing or swallowing.

  • Necrotizing Fasciitis

A rare but serious bacterial infection known as necrotizing fasciitis, which causes tissue damage in the perineal area, has been reported in individuals taking Jardiance. Symptoms include:

  • Swelling
  • Redness
  • Severe pain in the genital or perineal region
  • Elevated Glucose in Urinalysis

Jardiance can cause elevated glucose levels in urinalysis tests. This is expected due to its mechanism of action in promoting the excretion of glucose through the urine.

Ozempic

Below are the side effects of Jardiance, including:

  • Gastrointestinal Adverse Reactions

In clinical trials, it was observed that patients who received Ozempic experienced gastrointestinal adverse reactions at a higher frequency than those who received a placebo. Specifically, patients taking Ozempic 0.5 mg and 1 mg reported gastrointestinal adverse reactions of 32.7% and 36.4%, respectively, while only 15.3% of placebo patients reported such reactions. 

Most commonly, patients reported having symptoms such as:

  • Nausea
  • Vomiting
  • Diarrhea 

Additionally, a greater percentage of patients taking Ozempic 0.5 mg (3.1%) and Ozempic 1 mg (3.8%) discontinued treatment due to gastrointestinal adverse reactions compared to patients on placebo (0.4%). It’s important to note these findings in case you are taking or considering Ozempic.

  • Hypoglycemia

Another potential adverse reaction to Ozempic is hypoglycemia, which occurs when blood sugar levels drop too low. The percentage of hypoglycemia as an adverse reaction to Ozempic varies depending on the dosage and whether it is used alone or in combination with other medications. In placebo-controlled trials, the incidence of documented symptomatic hypoglycemia was 1.6% for Ozempic 0.5 mg and 3.8% for Ozempic 1 mg when used as monotherapy. 

When Ozempic was added to basal insulin with or without metformin, the incidence of documented symptomatic hypoglycemia was higher, with 16.7% for Ozempic 0.5 mg and 29.8% for Ozempic 1 mg. Additionally, severe hypoglycemia (requiring the assistance of another person) was reported in 0.8% of patients when Ozempic 0.5 mg was co-administered with a sulfonylurea and 1.2% when Ozempic 1 mg was co-administered with a sulfonylurea. Patients should be advised to monitor their blood sugar levels closely and report any symptoms of hypoglycemia to their healthcare provider.

  • Injection Site Reactions

Injection site reactions are another potential adverse reaction to Ozempic. In placebo-controlled trials, injection site reactions such as discomfort and erythema were reported in 0.2% of Ozempic-treated patients. Patients should be advised to rotate injection sites to minimize the risk of injection site reactions.

  • Increases in Amylase and Lipase

Patients exposed to Ozempic in placebo-controlled trials had a mean increase from baseline in amylase of 13% and lipase of 22%. These changes were not observed in placebo-treated patients. Amylase and lipase are enzymes that help digest food. An increase in these enzymes may indicate pancreas inflammation, a condition known as pancreatitis. Patients should be advised to report any symptoms of pancreatitis, such as abdominal pain, to their healthcare provider.

  • Cholelithiasis

Cholelithiasis, or the formation of gallstones, has been reported in patients treated with Ozempic. In placebo-controlled trials, cholelithiasis was reported in 1.5% and 0.4% of patients treated with Ozempic 0.5 mg and 1 mg, respectively. Cholelithiasis was not reported in placebo-treated patients. Patients should be advised to report any symptoms of cholelithiasis, such as abdominal pain and nausea, to their healthcare provider.

  • Increases in Heart Rate

Ozempic may cause a mean increase in heart rate of 2 to 3 beats per minute. In placebo-controlled trials, this increase was observed in both Ozempic 0.5 mg and 1 mg doses. In contrast, there was a mean decrease in heart rate of 0.3 beats per minute in placebo-treated patients. Patients with a history of cardiovascular disease should be monitored closely while taking Ozempic.

  • Fatigue, Dysgeusia, and Dizziness

Other adverse reactions associated with Ozempic include fatigue, dysgeusia (distorting the sense of taste), and dizziness. These reactions have a frequency of >0.4%. Patients should be advised to report these symptoms to their healthcare provider.

Drug Interactions

When taken with other medications, Jardiance and Ozempic can have drug interactions that limit their effectiveness or cause adverse effects. Below are the drug interactions of Jardiance and Ozempic:

Jardiance

Below are the drug interactions of Jardiance categorized by severity level:

Severe Interactions

  • Any other diabetes medications, like insulin or sulfonylureas (e.g., glyburide)
  • Other medications that can lower your blood sugar levels, like diuretics (water pills), corticosteroids, estrogens, oral contraceptives, nicotinic acid, and calcium channel-blocking drugs

Serious Interactions

  • Beta-blockers (e.g., atenolol, bisoprolol, propranolol)
  • Calcium channel blockers (e.g., amlodipine, felodipine, nifedipine)
  • Diuretics (e.g., bendroflumethizaide, bumetanide, furosemide)
  • ACE inhibitors (e.g., captopril, enalapril, ramipril)
  • Corticosteroids (e.g., betamethasone, fludrocortisone, prednisolone)
  • Anticonvulsants (e.g., carbamazepine, phenytoin, phenobarbital)

Moderate Interactions

  • Topical steroid treatments

Ozempic

Here are the drug interactions of Ozempic categorized by severity level: severe, serious, and moderate.

Severe Interactions

  • Antibiotics for bacterial infections, such as gatifloxacin
  • Bexarotene is used to treat skin cancer

Serious Interactions

  • Any other diabetes medications, like insulin or sulfonylureas
  • Diuretics, taken to make you lose water and salt, usually to treat high blood pressure – bumetanide, furosemide
  • Corticosteroids such as cortisone and prednisolone
  • Fenofibrate, taken to lower blood triglyceride levels
  • Beta 2-stimulants, taken to treat asthma – salmeterol
  • Antidepressants, including monoamine oxidase inhibitors and selective serotonin reuptake inhibitors – phenelzine, selegiline, sertraline
  • Disopyramide, taken to treat heart rhythm problems
  • Estrogen-containing drugs, including birth control and hormone replacements

Moderate Interaction

Steroids used topically (on the skin) such as:

  • Betamethasone
  • Clobetasol
  • Hydrocortisone
  • Mometasone

Dosage Form(s) Available

Jardiance and Ozempic are available in different forms and dosages. Jardiance comes in tablet form, while Ozempic comes in injection form. Let’s take a closer look at the dosage and forms of these medications:

Jardiance

  • Maintenance Dose: The maintenance dose of Jardiance is 10 mg or 25 mg once daily, taken orally.
  • Dosage Adjustment for Renal Impairment: No dosage adjustment is necessary for patients with mild to moderate renal impairment (eGFR 30 to less than 90 mL/min/1.73 m2). However, the glucose-lowering benefit of Jardiance 25 mg may decrease in patients with worsening renal function.
  • Missed Dose: If a dose of Jardiance is missed, it should be taken as soon as possible. However, if it is almost time for the next dose, the missed dose should be skipped, and the regular dosing schedule should be resumed. Doubling up on doses should be avoided.

Ozempic

Ozempic is available as an injection solution for subcutaneous use in the following strengths:

  • Maintenance Dose: The maintenance dose of Ozempic is administered once weekly. Patients should use it on the same day each week, at any time. As mentioned in the previous sections, the dosage strength options available are 0.25 mg/0.5 mL and 0.5 mg/1 mL.
  • Missed Dose: If a dose of Ozempic is missed, it should be administered as soon as possible, within 5 days after the missed dose. If more than 5 days have passed since the missed dose, patients should skip the missed dose and administer the next dose on the regularly scheduled day. In both cases, patients should then resume their regular once-weekly dosing schedule.

Jardiance vs Ozempic Cost

Understanding the cost of Jardiance and Ozempic is crucial for patients prescribed these medications. The cost of Jardiance and Ozempic can vary depending on a few factors, such as the patient’s insurance coverage and the pharmacy where the medication is purchased. 

Patients should check with their insurance provider to see if the medication is covered and, if so, what their co-pay or out-of-pocket cost will be. Manufacture coupons and patient assistance programs are available that can help reduce the cost of these medications. 

Jardiance

The cost of Jardiance can also vary depending on the strength and quantity of the selected medication. For instance, if you opt for a 10mg dose and select a quantity of 30 tablets, the cost of Jardiance will be $139.00. On the other hand, if you select a 25mg dose and 30 tablets, the price of Jardiance will be $149.00.

Recommendation

Jardiance is strongly recommended for effectively managing type 2 diabetes, given its proven ability to lower HbA1c levels and diminish cardiovascular risks. Priced at only $139.00 for a 30-tablet supply of 10mg strength, purchasing through Buy Canadian Insulin guarantees substantial cost savings compared to US prices, making it accessible and affordable for individuals seeking dependable diabetes medication. Additionally, with convenient online ordering and dependable express shipping, Jardiance from Canada offers a seamless experience for users aiming for optimal blood sugar management.

Ozempic

Ozempic is a medication that comes in the form of injection pens. Its price also varies depending on the strength and quantity selected. For instance, if you opt for the 2mg/3mL strength, you will get one pen for $469.79. Similarly, if you choose the 4mg/3mL strength, you will get one pen for $469.79.

Recommendation

Ozempic (Semaglutide) is another highly effective non-insulin medication for type 2 diabetes, aiding in weight loss and improving glycemic control. With significant cost savings compared to US prices, starting from $469.79 for a 3mL injection pen, purchasing Ozempic from Canada through Buy Canadian Insulin ensures reliable express shipping and easy ordering, making it an excellent choice for managing diabetes affordably and conveniently.

Conclusion

In conclusion, Jardiance and Ozempic are effective medications for treating type 2 diabetes. While each medication has its specific mechanism of action and side effects, the decision on which medication to use should be made based on the individual’s needs and in consultation with a healthcare provider. By understanding the differences between Jardiance and Ozempic, patients can make informed decisions that lead to better glycemic control and reduced risk of cardiovascular complications.

FAQs On Jardiance vs. Ozempic

Can you take Ozempic and Jardiance together?

Usually, yes. If one medication alone isn’t enough to control your blood sugar levels, combining Ozempic and Jardiance can help. They work differently, so they can cover more aspects of managing glucose levels and may provide better control.

What is the difference between the dosages of Jardiance and Ozempic?

Ozempic is a weekly injection approved for adults only, while Jardiance is a daily oral pill suitable for individuals aged 10 and above.