Ozempic (semaglutide) is an FDA-approved medication commonly prescribed to people with type 2 diabetes and often prescribed off-label for weight management. Its main function is to regulate blood sugar levels, which is crucial for managing the condition. However, people who have been using this medication for a while may wonder about the potential consequences of abruptly stopping it after 56 days.

If you stop taking Ozempic suddenly, your body may react negatively. You might experience a sudden spike in your blood sugar level, which can be unpredictable and dangerous. The effects of stopping Ozempic aren’t just limited to losing the benefits gained by the medication. There’s also the possibility of facing a setback in your health management. The weight you worked so hard to lose might return, and the stability in your blood sugar levels that you achieved could be lost. This can lead to feelings of frustration and uncertainty about how to maintain your health without the medication.

In this article, you will learn about the potential risks and consequences of stopping Ozempic treatment after 56 days. We will also provide helpful tips for safely discontinuing the medication under your doctor’s guidance to avoid adverse effects.

Key Takeaways

  • When you stop taking Ozempic after 56 days, your body’s ability to regulate blood sugar may decrease, potentially returning to pre-treatment levels. Ozempic’s active mechanism in controlling blood glucose levels stops without ongoing administration.
  • Any weight loss you experienced while taking Ozempic over the 56 days might gradually reverse. You may experience a return of appetite and a decrease in the metabolic benefits initially gained, leading to weight regain.
  • The metabolic rate, which may have increased due to Ozempic’s action on your body, could slow down. This means your body burns fewer calories at rest than it did while on the medication.
  • Once you stop taking Ozempic, you may notice an increase in hunger and appetite. The drug suppresses appetite as part of its action, so discontinuation can lead to a more intense return of hunger sensations.
  • For individuals using Ozempic for type 2 diabetes management, stopping the medication without replacing it with another effective treatment could increase the risk of complications associated with the condition due to less controlled blood sugar levels.
  • The gastrointestinal symptoms (like nausea or constipation) that some users experience when starting Ozempic typically subside over time but may briefly return upon stopping the medication as your body readjusts.
  • It’s crucial to consult with healthcare providers before discontinuing Ozempic, especially after a specific period like 56 days. They can offer guidance on managing potential rebound effects and suggest alternative treatments or adjustments to maintain health gains achieved during treatment.

What Happens if You Stop Taking Ozempic After 56 Days?

A person injecting Ozempic

If you discontinue the use of Ozempic after having taken it for 56 days, several potential outcomes may occur. Semaglutide is the active component of Ozempic, and stopping it can lead to different results depending on the individual. However, here’s what you can generally expect from discontinuing Ozempic:

Return of Appetite: Ozempic works by slowing digestion and affecting brain signals that control hunger and satisfaction from eating. This leads to a reduced appetite and a feeling of fullness for longer periods. After stopping Ozempic, these effects would diminish, leading to the return of your baseline appetite levels. This means you might start feeling hungrier and find it more challenging to adhere to a low-calorie diet as your sense of fullness reverts to its pre-medication state.

Weight Regain: Weight regain is likely after the return of your appetite to baseline levels. If you experienced weight loss while on Ozempic due to decreased food intake and an altered diet, these benefits may reverse upon stopping the medication, especially if the dietary and lifestyle modifications are not maintained. A clinical trial conducted in 2022 followed participants for 52 weeks after they stopped taking the medication. The study found that participants who took semaglutide for 68 weeks lost significant weight, but when the medication was stopped. Lifestyle changes ceased at 120 weeks (52 weeks later), and patients regained two-thirds of the weight they had previously lost.

Reversal of ‘Ozempic Face’: If you experienced changes in your facial appearance due to rapid weight loss, often referred to as “Ozempic face” (characterized by a more gaunt, shrunken appearance), stopping the medication and potentially regaining weight could reverse these changes, restoring your face to its fuller, pre-treatment appearance.

Blood Sugar Levels May Increase: For those using Ozempic primarily for type 2 diabetes management, halting the medication might increase blood sugar levels. Ozempic aids in controlling blood sugar by mimicking the effects of GLP-1, which can increase insulin secretion. Without the medication, your blood sugar levels could return to pre-treatment levels or potentially worsen, depending on your dietary intake and continued management of diabetes through other means.

How Long Does Ozempic Remain in Your System?

A person holding an Ozempic injection

According to the FDA-prescribing information, Ozempic has a half-life of approximately 1 week. This means it takes around 1 week for the drug’s concentration in your blood to decrease by half. Given this half-life, it typically takes about 5 to 6 weeks for Ozempic to be almost eliminated from your system.

This estimate is based on the general pharmacokinetic principle that drugs are considered fully eliminated after approximately 4 to 5 half-lives. However, your metabolic rate, age, health condition, and other personal characteristics can influence your system’s exact duration of the Ozempic.

Do the Side Effects of Ozempic Go Away After You Stop Taking It?

Yes, the common side effects of Ozempic, such as nausea, vomiting, diarrhea, stomach pain, and constipation, typically disappear within a few days to weeks after discontinuing the medication. However, after stopping Ozempic, especially at the highest dose of 2 mg, it may take a few weeks for the drug to leave your body completely, and you might still experience some side effects during this period. If the side effects last for months or are particularly bothersome, you should speak with your healthcare provider for further guidance and management.

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Why People Consider Stopping Ozempic

People might consider stopping Ozempic for several reasons, including experiencing side effects, facing cost and accessibility challenges, or because of personal health changes. Side effects are a common reason, with some individuals experiencing gastrointestinal issues like nausea or digestive discomfort, which can impact their daily lives.

For instance, the studies reported that gastrointestinal disorders were higher in the Semaglutide (Ozempic) group than in placebo or other treatments, leading to treatment discontinuation in 2.9% to 9.7% of participants. Cost and accessibility also play a significant role, as Ozempic can be expensive and not always covered by insurance, making it difficult for some patients to continue the treatment.

Additionally, personal reasons such as changes in health status or deciding the medication isn’t the right fit for their lifestyle or treatment goals might lead patients to stop using Ozempic.

How to Safely Discontinue Ozempic

How to Safely Discontinue Ozempic

If you are planning to discontinue the use of Ozempic, it is important to do so safely. To ensure a smooth transition, it is recommended that you follow these five essential steps:

Consult Your Doctor: Before deciding to stop taking Ozempic, consult your healthcare provider. They can offer guidance on the risks and benefits of discontinuation and help develop a safe plan for tapering off the medication. This step is crucial to avoid potential adverse effects or complications of abrupt cessation.

Gradual Tapering: It’s recommended to taper off your Ozempic dose gradually instead of stopping abruptly. This allows your body to adjust to lower doses over time, minimizing potential side effects and reducing the risk of significant spikes in blood sugar levels and weight regain. Your doctor can provide a tailored tapering schedule.

Monitor Blood Sugar Levels: Especially for those using Ozempic for diabetes management, closely monitoring your blood sugar levels is critical during the discontinuation phase. This will help you quickly identify any concerning changes in your blood sugar and address them promptly to avoid complications.

Adopt Healthy Lifestyle Changes: To sustain the weight loss achieved while on Ozempic and maintain overall well-being, adopt healthy lifestyle changes. Focus on a diet rich in dietary fiber, lean proteins, and healthy fats. Engage in regular physical activity, aiming for at least 150 minutes of moderate to vigorous activity weekly. These changes can help manage hunger, provide essential nutrients, and support weight management.


If you plan to continue using Ozempic beyond the initial 56 days and are concerned about the high cost of the medication in the US, there is an alternative solution. Buy Canadian Insulin provides Ozempic at prices that are much lower than those commonly found in the US market, starting at just $469.79 for both the 2mg/3mL and 4mg/3mL pens. This translates to an average cost of approximately $156.60 per mL, making it a great value for your healthcare expenditure.

Final Thoughts

Stopping Ozempic after 56 days may cause several negative effects, such as weight regain, increased appetite, and potential blood sugar level spikes. It is important to consult with your doctor before discontinuing the medication and to follow their guidance for safe discontinuation. Although Ozempic’s side effects may subside after stopping the medication, it is crucial to maintain a healthy lifestyle to avoid potential setbacks in your health management.

FAQs On Stopping Ozempic

Can you still use Ozempic after 56 days?

After opening the Ozempic pen, you can store it either in the refrigerator or at room temperature, but for different periods. If you store it in the refrigerator, you can use it for up to 56 days. However, if you prefer to store it at room temperature, use it within 28 days. It is important to note that you should discard the pen after 56 days of use, even if the medicine is still left inside.

What happens if you stop Ozempic for a month?

If you stop taking Ozempic for a month, you may experience a reversal of its benefits. This can include a return of elevated blood sugar levels if you are using it for diabetes management or a halt in weight loss progress if you use it for weight management. It’s important to discuss any changes to your medication regimen with your healthcare provider, as they can provide guidance tailored to your specific situation.

How long can you go without taking Ozempic?

The duration you can go without taking Ozempic depends on your treatment plan and health condition. However, missing doses or discontinuing the medication without a healthcare provider’s advice can lead to less effective treatment outcomes. Taking it as soon as you remember is generally recommended if you miss a dose unless it’s almost time for your next dose. Always consult with your healthcare provider for advice specific to your situation.

What happens after 6 weeks of Ozempic?

After 6 weeks of Ozempic, many individuals may start to see significant benefits from the medication, including improved blood sugar control in people with type 2 diabetes and potentially weight loss in those using it for weight management. The full effects of Ozempic, however, may take longer to manifest. It’s important to continue using the medication as directed by your healthcare provider and to maintain any recommended diet and exercise plans for the best outcomes.


U.S. Food and Drug Administration. (2024, January 10). Medications Containing Semaglutide Marketed for Type 2 Diabetes or Weight Loss. Retrieved from https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/medications-containing-semaglutide-marketed-type-2-diabetes-or-weight-loss

Wilding, J. P. H., Batterham, R. L., Davies, M., Van Gaal, L. F., Kandler, K., Konakli, K., Lingvay, I., et al. (2022). Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension. Diabetes, Obesity and Metabolism.https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.14725

Novo Nordisk. (2017). Ozempic (semaglutide) injection, for subcutaneous use – Highlights of Prescribing Information. FDA. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209637lbl.pdf

Drugwatch. (2024, February 21). Ozempic (Semaglutide) Side Effects: FDA Warnings & Weight Loss. Drugwatch. https://www.drugwatch.com/drugs/ozempic/side-effects/

National Center for Biotechnology Information. (n.d.). Results – Clinical Review Report: Semaglutide (Ozempic) [Web page]. In Clinical Review Report: Semaglutide (Ozempic): (Novo Nordisk Canada Inc.): Indication: For the treatment of adult patients with type 2 diabetes mellitus to improve glycemic control, in combination with metformin (second-line treatment), and in combination with metformin and sulfonylurea (third-line treatment). NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK544016/

Mayo Clinic. (2024). Semaglutide (Subcutaneous Route) Precautions. In Drugs and Supplements. Retrieved from https://www.mayoclinic.org/drugs-supplements/semaglutide-subcutaneous-route/precautions/drg-20406730