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Avandia (rosiglitazone)

Prescription Required.

Product of Canada.

Express Ships from Canada.

Prescription Required.
Product of Canada.
Express Ships from Canada.

WHAT IS AVANDIA (rosiglitazone)?

Avandia, also known as rosiglitazone, is an oral prescription medication. It is indicated in adults with type 2 diabetes mellitus (T2DM) to improve glycemic control in addition to diet and exercise. Avandia has some limitations to its use. These include:

  • Because of its mechanism, Avandia only works if endogenous insulin is available. Therefore, Avandia is not indicated for type 1 diabetes mellitus (T1DM) or diabetic ketoacidosis
  • Avandia is not recommended to be used concomitantly with insulin

Controlling hyperglycemia with Avandia prevents downstream complications such as kidney damage, loss of limbs, blindness, heart attack, stroke, or nerve problems. It is important that diabetes remains controlled to lessen the chance of related complications.

HOW DOES AVANDIA WORK?

Rosiglitazone is an antidiabetic agent belonging to the thiazolidinedione class. It betters glycemic control by increasing the body’s sensitivity to insulin. It is a potent and selective agonist of the peroxisome proliferator-activated receptor-gamma (PPAR?). The PPAR receptor is located in tissues key to insulin activity. These include adipose tissue, the liver, and skeletal muscle. When the PPAR? is activated, the body initiates transcription of genes that promote insulin response and glucose control. They PPAR? is also a key player in fatty acid metabolism.

Insulin resistance plays a key role in the pathophysiology diabetes. In animal models, Avandia decreases concentrations of blood glucose and lessens hyperinsulinemia through action in the muscle, liver, and adipose tissues. Avandia has also been shown to block gluconeogenesis in the liver. Avandia has also not demonstrated hypoglycemia or altered glucose tolerance in animal studies.

 SIDE EFFECTS

Common side effects of Avandia include:

  • Headache
  • Cough
  • Upper respiratory tract infection
  • Cold symptoms such as a stuffy nose, sore throat, or sneezing
  • Back pain
  • Diarrhea
  • Drowsiness

WARNINGS AND PRECAUTIONS

Cardiac Failure

The thiazolidinedione class is known to exacerbate or cause heart failure. Avandia, alone or with other antidiabetic agents, can cause fluid retention leading to heart failure. Physicians should monitor patients for signs and symptoms of heart failure, including:

  • Shortness of breath at rest or with activity
  • Fatigue and weakness
  • Swelling

If patients demonstrate symptoms of heart failure, providers should implement proper standards of care. Additionally, Avandia should be discontinued or dose-reduced. If patients have confirmed NYHA Class III or IV heart failure, Avandia is contraindicated. It is not recommended in those who have symptomatic heart failure.

Major Adverse Cardiovascular Events

A meta-analysis of short-term trials demonstrated an elevated risk of myocardial infarction with Avandia treatment versus placebo. However, longer-term studies did not show any increase in mortality or major adverse cardiovascular events (MACE) with Avandia compared with placebo.

Edema

In one study, there was a significant increase in median plasma volume in those treated with Avandia compared with placebo. Patients were more likely to experience adverse events if they were on concomitant therapy with Avandia and insulin. Therefore, in patients with edema, Avandia should be used cautiously.

Additionally, because thiazolidinediones can cause fluid retention, congestive heart failure can be worsened. Providers should monitor patients for heart failure symptoms.

Weight Gain

Patients on Avandia both alone and in combination with other antidiabetic agents have demonstrated dose-related weight gain. Weight gain was likely associated with fat accumulation and fluid retention. Patients who exhibit weight gain should be evaluated for edema and congestive heart failure.

Hepatic Effects

Providers should measure liver enzymes in all patients prior to starting Avandia and frequently throughout therapy. Avandia should not be used in those who have elevated baseline liver enzyme levels with ALT greater than 2.5 times the upper limit of normal. Those with only mildly increase liver enzyme levels (less than 2.5 times the upper limit of normal) should use caution and be closely monitored. If enzyme levels increase to more than three times the upper limit of normal, Avandia should be stopped. Additionally, if the patient develops jaundice, Avandia should be discontinued.

Macular Edema

Thiazolidinediones, including Avandia, have been shown to cause macular edema. In trials, macular edema presented as blurred vision and lessened visual acuity. Some patients were asymptomatic. However, most individuals also were experiencing peripheral edema in addition to their macular edema. Diabetic patients and patients on Avandia should have routine eye exams.

Fractures

Studies have demonstrated an increased frequency of bone fractures amongst females taking Avandia. Fractures typically occurred in the feet, hands, and upper arms. Providers should consider the fracture risk of the patient before starting Avandia and evaluate appropriately.

Hematologic Effects

Individuals on Avandia also demonstrated dose-related reductions in hematocrit and mean hemoglobin. This is likely due to Avandia’s effect on plasma volume.

Diabetes and Glucose Control

Individuals on other hypoglycemic drugs concomitantly with Avandia may be at increased risk for hypoglycemia. Providers may want to consider reducing the Avandia dose if patients are also on other antidiabetic agents.

DRUG INTERACTIONS

CYP2C8 Inhibitors and Inducers

CYP2C8 inducers such as rifampin may decrease the area under the curve (AUC) of Avandia. CYP2C8  inhibitors such as gemfibrozil may elevate Avandia’s AUC. Physicians should consider altering therapy if a patient is on a concomitant drug that affects Avandia concentrations.

USE IN SPECIFIC POPULATIONS

Pregnancy

There is not much data available evaluating Avandia during pregnancy. It is not known if Avandia can cause miscarriage or major birth defects. Providers should consider the risks of uncontrolled diabetes during pregnancy when determining if therapy is appropriate.

Lactation

There is no data evaluating Avandia’s presence in human milk, potential effects of Avandia on a breastfed infant, or its influence on milk production. Animal data, though, demonstrates presence of Avandia in rat milk. Animal models, however, are not always indicative of a drug’s effects in humans. Providers should consider the risks of uncontrolled diabetes in the mother and the potential adverse effects of the drug on the infant.

Reproduction

Other thiazolidines have induced ovulation in previously anovulatory women. Providers and patients should consider the risk of unintended pregnancy in premenopausal women looking to start Avandia.

Geriatrics

Pharmacokinetic studies of Avandia indicate that age does not affect Avandia’s safety and efficacy. There were no differences in efficacy or safety when comparing those over the age of 65 and those under the age of 65. In older adults, no dose alterations are necessary.

AVANDIA PRICE & COUPONS

For many patients in the United States, the financial toll of managing type 2 diabetes can be significant, especially when it comes to purchasing essential medications like Avandia. Without medical insurance coverage, the cost for Avandia can pose a substantial financial burden.

However, there’s a more affordable option available through Buy Canadian Insulin (BCI), a prescription-referral service that allows Americans to get access to affordable medication through a licensed Canadian pharmacy at low prices. Through BCI, the Avandia price starts at $129.95, providing much-needed financial relief for Americans without insurance or those who have fallen into the medical coverage gap.

Discount Code Discount Offer

To further assist patients in managing their healthcare expenses, BCI offers a special discount. By using the coupon code AVANDIA10, customers can enjoy a 10% discount when they buy Avandia. This additional discount helps reduce the overall cost, making the medication more affordable, with a limit of one use per customer and a maximum savings of $50.

Savings on Bulk Purchases

Patients are encouraged to order in bulk, with options extending to a 90-day supply, to maximize their savings. The pricing for Avandia with the following bulk discount options is as below:

Brand: Avandia (Rosiglitazone Maleate)

2mg Tablets:

  • 60 tabs: $129.95
  • 120 tabs: $252
  • 180 tabs: $375

4mg Tablets:

  • 100 tabs: $269.95
  • 200 tabs: $520
  • 300 tabs: $750

Generic Equivalent (Rosiglitazone Maleate)

2mg Tablets:

  • 100 tabs: $179.99
  • 200 tabs: $350
  • 300 tabs: $510

4mg Tablets:

  • 100 tabs: $219.00
  • 200 tabs: $430
  • 300 tabs: $630

8mg Tablets:

  • 100 tabs: $299.00
  • 200 tabs: $590
  • 300 tabs: $870

Opting for larger quantities not only ensures convenience but also leads to significant cost reductions over time. As with any medication, patients are limited to a 90-day supply.

Assurance of Quality and Timely Delivery

Avandia is shipped in state-of-the-art, refrigerated gel pack containers to preserve its quality throughout the shipping process. Customers can expect their orders to arrive within 3-5 business days after processing, guaranteeing swift access to their medication.

By opting to purchase Avandia from Canada, patients in the U.S. can substantially alleviate the financial impact of their diabetes treatment. This service is especially beneficial for those without insurance coverage, ensuring broader access to necessary treatments at manageable costs.

We take great care to ensure that all orders requiring cold shipping are packed in medical-grade, refrigerated gel pack containers to maintain the highest quality of your products. However, please be advised that unforeseen conditions such as weather, climate, and political issues may cause some delays in delivery.

FREQUENTLY ASKED QUESTIONS

Avandia should be taken as your doctor directs you to take it. The normal starting dose is 4 mg once daily or 2 mg twice daily. Depending on your blood sugar response, your provider may alter your dose. Avandia may also be taken with other diabetes medications if your blood sugar needs more control.

You should regularly test your blood sugar while on Avandia. Additionally, it is important to maintain a proper diet and exercise plan while on Avandia. These can help your body to normalize its blood sugar levels.

Avandia can be taken with or without regard to food.

If you forget to take a dose, take it as soon as you remember. Take the next dose of Avandia at its scheduled time. Do not take two doses at once, however.

Avandia can be taken long-term to control type II diabetes mellitus.

If you overdose on Avandia, you should immediately go to the emergency room or contact the Poison Control Center. Overdosing on Avandia increases an individual’s chance of developing hypoglycemia.

Common side effects of Avandia include:

  • Headache
  • Cough
  • Upper respiratory tract infection
  • Cold symptoms such as a stuffy nose, sore throat, or sneezing
  • Back pain
  • Diarrhea
  • Drowsiness

Serious side effects of Avandia include:

  • New or worsened heart failure
  • Swelling (edema)
  • Heart attack
  • Liver issues
  • Weight gain
  • Macular edema (swelling in the back of the eye)
  • Broken bones
  • Low blood sugar
  • Low red blood cell count

It is important that you tell your doctor all of the medications, vitamins, and supplements that you take. Keep a list to show your provider or pharmacist before starting any new medication. Other medications may affect your blood sugar when used with Avandia, causing it to be too high or too low. Tell your provider especially if you are taking:

  • Medications for high blood pressure
  • Medications for heart failure
  • Medications for high cholesterol
  • Medications to prevent heart disease or stroke
  • Insulin

It is also important to let your doctor know if you:

  • Have heart failure or heart problems
  • Have liver issues
  • Have an eye problem known as macular edema
  • Have type 1 diabetes or diabetic ketoacidosis
  • Are pregnant or plan to become pregnant
  • Are breastfeeding or plan to breastfeed

Avandia should be kept at room temperature between 59°F and 86°F (15°C and 30°C). Avandia should be left in the container it was provided in. Keep Avandia out of reach from children. If Avandia becomes expired or is no longer needed, safely throw it away.