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Cozaar (Losartan)

Prescription Required.

Product of Canada.

Express Ships from Canada.

Prescription Required.
Product of Canada.
Express Ships from Canada.

Cozaar (Losartan)

What is Cozaar (Losartan)?

Cozaar (losartan) is an angiotensin II receptor antagonist that is prescribed for the management of hypertension in those above the age of six years old. It may also be prescribed to reduce the progression of kidney damage in patients with type 2 diabetes and hypertension, as well as to reduce the risk of stroke in those who have certain heart diseases.

How is Cozaar Used?

This medication should be taken orally, and the dosage will vary based on the condition for which it has been prescribed. In general, it is taken once per day, and it may be taken with a meal or without any food.

Patients should strive to take this medication at the same time each day and in the same manner for maximum efficacy, and they should continue using the medication even if they begin to feel well during treatment.


Cozaar tablets should be stored as close to 77°F (25°C) as possible. However, it is safe to temporarily expose this medication to temperatures as low as 59°F (15°C) or as high as 86°F (30°C). It should remain stored away from light and in a tightly sealed container.

Keep this medication out of the reach of children at all times.


Cozaar is prescribed for a variety of conditions, including but not limited to:

  • hypertension (high blood pressure)
  • diabetic neuropathy
  • cardiovascular disease
  • eclampsia
  • pre-eclampsia
  • hypertensive congestive heart failure
  • hypertensive heart disease
  • hypertensive heart and renal disease
  • hypertensive renal disease
  • hypertensive retinopathy
  • renovascular hypertension

How Does Cozaar Work?

Cozaar is an angiotensin II receptor blocker, otherwise known as an ARB blocker. This type of medication functions by inhibiting the angiotensin II within the patient’s body, blocking the chemical’s action of triggering the constriction of blood vessels. Inhibiting this constriction allows the patient’s blood vessels to relax, lowering their overall blood pressure and reducing the symptoms of hypertension.

This medication may be used by itself or alongside treatment with diuretics, and the full effects of the treatment are most commonly seen within three to six weeks.


Cozaar is available in tablet form in the following strengths:

  • 25 mg
  • 50 mg
  • 100 mg

When used for the treatment of high blood pressure in adult patients, the most commonly prescribed dosage is a once-daily dose of 50 mg. If a patient is currently using diuretics, they may be recommended to start with a dose of 25 mg.

Patients with type 2 diabetes will most commonly begin treatment with a dose of 50 mg once per day. In most cases, this dosage will be increased to a once-daily administration of 100 mg over time based on the patient’s response to treatment.

Individuals with any type of impaired liver function will typically begin treatment with a once-daily dose of 25 mg. However, there have not been any studies performed regarding patients with severely impaired liver function using this medication.


If an overdose has occurred or suspected, the patient’s prescribing physician or their local Poison Control Center should be contacted as soon as possible. Overdose symptoms may include loss of consciousness or extreme dizziness. If an overdose has occurred and the individual loses consciousness or has difficulty breathing, emergency medical attention should be sought immediately.

Side Effects

The most common side effects of taking Cozaar are as follows:

  • back pain
  • cold symptoms
  • dizziness
  • sneezing
  • sore throat
  • stuffy nose

Some of the following additional side effects may occur and should be discussed with your doctor if they remain persistent or increase in severity while taking Cozaar:

  • back pain
  • changes in taste
  • coughing
  • diarrhea
  • fatigue
  • feeling dizzy
  • headaches
  • leg pain
  • muscle cramps
  • vomiting

Please contact your doctor immediately if you experience any of the following serious side effects:

  • heart palpitations
  • hyperkalemia
  • loss of consciousness
  • skin rash
  • symptoms of clotting issues
    • bleeding gums
    • blood in the urine
    • coughing up blood
    • cuts that will not stop bleeding
    • unusual nosebleeds
  • symptoms of hepatic impairment
    • appetite loss
    • dark urine
    • diarrhea
    • jaundice (yellowing of the eyes or skin)
    • nausea
    • pale-colored stools
    • vomiting
    • weight loss
  • symptoms of renal impairment
    • blood in the urine
    • changes in urine color or amount produced
    • increased nighttime urination
    • swelling in the legs or feet
  • unexplained weakness, urine that’s dark brown, or muscle pain

Warnings & Precautions


Although this medication may be used in those above the age of six years old, its efficacy and safety have not been determined in those below the age of six.


It has not been determined if Cozaar passes into breast milk, so those who are using this medication and desiring to breastfeed should discuss the potential risks of this combination with their physician.


Those using this medication may experience dizziness, and this can impact their ability to perform certain tasks, including activities likes driving and operating machinery. Patients using Cozaar are advised to avoid engaging in certain activities until they are able to determine how the medication affects them and their coordination.


Cozaar has been linked to the development of high potassium levels in patients’ blood. Although this condition is not always problematic, some individuals may require monitoring with blood testing to ensure that any hyperkalemia is well-managed.


When first beginning treatment with Cozaar, some patients experience a notable drop in blood pressure resulting in hypotension. This unusually low drop in blood pressure is more likely to happen in those who experience vomiting or diarrhea, have a low salt diet, are on dialysis, or currently take diuretics. When hypotension occurs after beginning treatment with this medication, these individuals should also exercise caution when sitting up or changing positions due to a high risk of dizziness.

Kidney Function

There is a risk of impaired kidney function in those using Cozaar for treatment. This risk is higher for those who already have kidney-related conditions, those with congestive heart failure, and those with narrowed blood vessels in the kidneys. This risk further increases when patients are also taking aliskiren, non-steroidal anti-inflammatory drugs (NSAIDs), or diuretics. Individuals with a history of kidney-related problems or impaired kidney function may require additional monitoring while using this medication.

Liver Function

Individuals with impaired liver function may experience a buildup of the medication within their bodies, resulting in an increased risk of adverse effects. Those with liver-related conditions that may affect the rate at which this medication will be excreted from the body should inform their doctor of these conditions before beginning treatment, and this may impact their prescribed dosage as well as result in them requiring additional monitoring to ensure that Cozaar is working both safely and effectively.


Individuals that are pregnant should not use Cozaar due to the serious risks that this medication poses to developing and unborn children. Using this medication during pregnancy can result in harm to the unborn child and even death. Those who are using this medication and become pregnant should inform their prescribing physician immediately. If you are planning to become pregnant and currently using Cozaar, discuss alternative medication options with your doctor.

Additional Medical Conditions

If you have any of the following medical conditions, exercise caution when taking this medication and discuss your medical history with your doctor before beginning treatment:

  • congestive heart failure
  • dehydration
  • electrolyte imbalances
  • if you are currently on a diet low in salt
  • kidney disease
  • liver disease

Drug Interactions

Speak to your doctor about any medications or herbal supplements you are currently taking before beginning treatment with this medication. Discuss any concerns you may have with your doctor or a trusted pharmacist.

The following medications, supplements, and other substances are known to interact with Cozaar:

  • aldesleukin
  • alfuzosin
  • aliskiren
  • alpha-agonists
  • alpha-blockers
  • amifostine
  • amiloride
  • amiodarone
  • amlodipine
  • angiotensin-converting enzyme inhibitors (ACEIs)
  • angiotensin receptor blockers (ARBs)
  • antipsychotics
  • apalutamide
  • atenolol
  • “-azole” antifungals
  • barbiturates
  • beta-adrenergic blockers
  • bosentan
  • brimonidine
  • calcium channel blockers
  • carbamazepine
  • candesartan
  • captopril
  • ceritinib
  • chlorpromazine
  • chlorpropamide
  • clonidine
  • clozapine
  • conivaptan
  • cyclosporine
  • dabrafenib
  • dalteparin
  • deferasirox
  • delavirdine
  • diabetes medications
  • diclofenac
  • digoxin
  • diltiazem
  • diuretics
  • doxazosin
  • drospirenone
  • duloxetine
  • efavirenz
  • enzalutamide
  • eplerenone
  • etravirine
  • furosemide
  • ginger
  • ginseng
  • glyburide
  • guanfacine
  • haloperidol
  • heparin
  • HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs)
  • hydrochlorothiazide
  • ibuprofen
  • indapamide
  • irbesartan
  • isosorbide dinitrate
  • isosorbide mononitrate
  • itraconazole
  • ketoconazole
  • levodopa
  • lisinopril
  • lithium
  • low-molecular-weight heparins
  • lumacaftor
  • medications that increase potassium levels
  • methyldopa
  • methylphenidate
  • mifepristone
  • minoxidil
  • mitotane
  • moclobemide
  • modafinil
  • monoamine oxidase inhibitors (MAOIs)
  • naproxen
  • nevirapine
  • nifedipine
  • nitrates
  • nitroglycerin
  • non-steroidal anti-inflammatory medications (NSAIDs)
  • obinutuzumab
  • olanzapine
  • pentobarbital
  • pentoxifylline
  • phenelzine
  • phenobarbital
  • phenytoin
  • phosphodiesterase 5 inhibitors
  • pioglitazone
  • propranolol
  • quetiapine
  • quinine
  • ramipril
  • rasagiline
  • repaglinide
  • rifabutin
  • rifampin
  • riociquat
  • risperidone
  • ropinirole
  • sacubitril
  • salt substitutes containing potassium
  • sarilumab
  • selegiline
  • sildenafil
  • sodium phosphates
  • sotalol
  • spironolactone
  • John’s wort
  • tadalafil
  • tamsulosin
  • tizanidine
  • tinzaparin
  • tocilizumab
  • tolvaptan
  • tranylcypromine
  • triamterene
  • trimethoprim
  • vardenafil
  • verapamil
  • voriconazole
  • warfarin
  • water pills
  • yohimbine

Alternative Medications

For patients who are unable to take Cozaar or experiencing significant adverse side effects, alternative medications may be used to treat some of the associated conditions for which this medication is commonly prescribed:

  • amlodipine (Norvasc)
  • atenolol
  • carvedilol (Coreg)
  • hydrochlorothiazide
  • lisinopril (Qbrelis, Prinivil, Zestril)
  • metoprolol (Lopressor, Toprol XL)

Frequently Asked Questions

Before taking Cozaar, patients should inform their physician if they have any liver or kidney problems, if they experience a lot of diarrhea or vomiting, if they are breastfeeding, or if they are pregnant or planning to become pregnant. Patients should also be sure to inform their doctor of their medical history as well as any current medications they may be taking.

Individuals should not take Cozaar if they have diabetes and are simultaneously taking a medication named aliskiren or if they have an allergy to Cozaar or any of the additional ingredients in the medication.

The most important information that one should know about Cozaar is that this medication is capable of harming an unborn child and may even cause its death. Patients that are using Cozaar and become pregnant should inform their physician immediately. If you are planning to become pregnant, you should discuss this matter with your prescribing physician and determine a safer medication or treatment for managing your high blood pressure.

Cozaar should be taken in the exact manner as prescribed by your doctor. Any missed doses should be taken as soon as the patient remembers, but if it’s near the time of the next scheduled dose, the missed dose should not be made up to avoid too much of the medication being present within the individual’s system at once. If an overdose of this medication occurs, the person that has consumed too much of this medication should go to their nearest emergency room, contact their physician, or contact their local Poison Control Center.

Patients with high blood pressure that are using this medication are most likely to experience side effects such as back pain, cold-like symptoms, feeling dizzy, and having a stuffy nose.

Some of the more serious side effects that can occur when using this medication include the following: hyperkalemia, worsening of kidney function, hypotension, injury to an unborn child (in pregnant patients), death of an unborn child, or serious allergic reactions.

This medication should be stored in temperatures ranging between a low of 59°F (15°C) to a high of 86°F (30°C) and should be kept tightly sealed in a container away from children as well as away from any exposure to light.

The active ingredient in Cozaar is losartan potassium. The following inactive ingredients are also included in this medication: titanium dioxide, hypromellose, hydroxypropyl cellulose, magnesium stearate, pregelatinized starch, lactose hydrous, and microcrystalline cellulose. Additionally, the 25 mg, 50 mg, and 100 mg versions of this medication may include carnauba wax.

Cozaar is an angiotensin receptor blocker (ARB) medication that is used in the treatment of hypertension, to reduce the progression of kidney disease associated with type 2 diabetes in those who currently have or have previously had hypertension, and to reduce the stroke risk in those with left ventricular hypertrophy that also have hypertension.

Patients with type 2 diabetes and diabetic kidney disease that take this medication are most likely to experience symptoms of hypotension, hyperkalemia, hypoglycemia, fatigue, diarrhea, and chest pain.

Yes. Patients using this medication should not consume grapefruit or grapefruit juice due to this resulting in a buildup of the medication within the body. It is also advised that they avoid alcohol, salt substitutes, and potassium supplements as well.

As an angiotensin II receptor blocker, Cozaar works by blocking the constriction-causing angiotensin chemicals within the body and relaxing a person’s blood vessels to lower blood pressure levels.

This medication is available in tablet forms in strengths of 25 mg, 50 mg, and 100 mg.

There are multiple warnings and precautions associated with this medication. These include the following risks: hypotension, dizziness, a buildup of the medication within the patient’s system due to impaired liver function, kidney impairment, hyperkalemia, and a risk of harm or death to an unborn child in patients that are or become pregnant.

This medication may be prescribed for the treatment of hypertensive heart disease, renovascular hypertension, hypertensive renal disease, hypertensive encephalopathy, hypertensive retinopathy, hypertensive heart with renal disease, hypertensive congestive heart failure, cardiovascular disease, eclampsia, pre-eclampsia, hypertension, and diabetic neuropathy.

Patients should not breastfeed while using this medication. Cozaar is not safe for use during pregnancy due to the risk of harm and death to an unborn child. Those using this medication that become pregnant should inform their prescribing physician immediately.

Individuals using this medication that have missed a dose should take the dose as soon as they remember. However, if taking the missed dose would be done too close to the next scheduled dose, the missed dose should simply remain skipped, and the patient should only take their next scheduled dose. At no point should two doses of Cozaar be taken at once.

If someone has overdosed on this medication, their physician or their local Poison Control Center should be contacted as soon as possible. If an overdose has occurred and serious symptoms such as loss of consciousness or difficulty breathing occur, emergency medical attention should be sought immediately.