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Dabigatran (Generic) Dabigatran Etexilate Mesylate
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Apo-Dabigatran (Generic) Dabigatran Etexilate Mesilate
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What is Dabigatran?

Dabigatran, marketed under the brand name Pradaxa, is a direct thrombin inhibitor anticoagulant used to prevent blood clots. This medication works by blocking thrombin, an enzyme crucial in the blood clotting process, helping reduce the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation. Dabigatran also treats and prevents deep vein thrombosis (DVT) and pulmonary embolism (PE).

Fact Category Fact Details
Generic Name Dabigatran Etexilate
Medication Class Direct Thrombin Inhibitor
Primary Use Prevention of stroke and systemic embolism in non-valvular atrial fibrillation
Additional Benefit Treatment and prevention of DVT and PE
Available Form Capsules (75 mg, 110 mg, 150 mg)
Method of Administration Oral
Frequency Twice daily
Storage Instructions Store at room temperature (15-30°C/59-86°F); protect from moisture
Pregnancy and Breastfeeding Consult your healthcare provider before use
Drug Interactions NSAIDs, antiplatelet agents, other anticoagulants, rifampin, ketoconazole, dronedarone
Manufacturer Boehringer Ingelheim

Cost & Ordering Information

Buy Dabigatran Through Buy Canadian Insulin

Buy Canadian Insulin helps patients access dabigatran through participating pharmacy partners.

Pricing may vary depending on product strength, quantity selected, supplier availability, and participating pharmacy partner pricing policies.

Some patients may find pricing through participating pharmacy partners that differs from certain U.S. retail pharmacy prices.

Available services may include:

  • Pricing options based on quantity selected
  • Prescription processing through participating pharmacy partners
  • Shipping options available across eligible U.S. delivery locations
  • Ordering support through phone, email, or live chat
  • Multiple quantity options depending on prescription authorization and supplier availability

Dabigatran is a prescription medication that requires review and approval by a licensed healthcare professional and pharmacist before dispensing, where applicable.

Shipping timelines may vary depending on prescription review requirements, inventory availability, destination location, customs review, and carrier services.

Prescription Requirement

A valid prescription from a licensed healthcare provider is required before dabigatran can be dispensed.

Patients may submit their prescription during checkout or send it separately using one of the approved prescription submission methods.

Prescription Medication Discounts and Coupons

Eligible first-time customers may use coupon code FIRST10 during checkout for qualifying orders, subject to current promotional terms and conditions.

Ordering Information

Have a prescription?

Patients may explore available dabigatran prescription options through participating pharmacy partners.

Available ordering features may include:

  • Pricing options based on quantity selected
  • Multiple quantity options depending on prescription details
  • Shipping options with tracking availability when provided by the carrier
  • Customer support assistance through phone, email, or live chat
  • Online and phone ordering availability

Pharmacist Consultation Availability

Licensed pharmacists are available to answer questions regarding dabigatran, including administration instructions, storage recommendations, possible side effects, and medication interactions.

Patients should consult their healthcare provider or pharmacist before starting, stopping, or changing treatment.

Important Treatment Information

Dabigatran is an anticoagulant, also called a blood thinner. It may increase the risk of serious bleeding.

Patients should take dabigatran exactly as prescribed and should not stop treatment without speaking with their healthcare provider.

Tell your healthcare provider right away if you notice unusual bleeding, black or bloody stools, blood in the urine, vomiting blood, severe headache, dizziness, weakness, or any signs of serious bleeding.

Patients should also tell all healthcare providers, dentists, and surgeons that they take dabigatran before any procedure.

What Are the Benefits of Dabigatran?

  • Reduces stroke risk in patients with non-valvular atrial fibrillation by preventing blood clot formation
  • Treats existing blood clots in the legs (deep vein thrombosis) and lungs (pulmonary embolism)
  • Prevents recurrent DVT and PE after initial treatment
  • Offers predictable anticoagulation without routine blood monitoring requirements
  • Provides rapid onset of action, typically within 2 hours
  • Features a specific reversal agent (idarucizumab) available if emergency reversal is needed

For comprehensive information on anticoagulant therapy, consult resources from the American Heart Association.

Dosage

Standard Dabigatran dosing is 150 mg taken twice daily for most adults with non-valvular atrial fibrillation. For patients with moderate renal impairment or those taking certain medications, the dose may be reduced to 75 mg twice daily. Your healthcare provider will determine the appropriate dosage based on your kidney function, age, weight, and other medications. Always follow your prescriber’s specific instructions for your situation.

Dosage Chart

Population / Condition Dosage Recommendation Frequency Route of Administration Notes
Non-valvular atrial fibrillation (standard) 150 mg Standard adult dose Twice daily Oral For stroke prevention
Moderate renal impairment (CrCl 30-50 mL/min) 75 mg Reduced dose Twice daily Oral When co-administered with dronedarone or systemic ketoconazole
DVT/PE treatment 150 mg After 5-10 days of parenteral anticoagulation Twice daily Oral Initial treatment with heparin required
DVT/PE prevention (recurrence) 150 mg Long-term prevention Twice daily Oral After completing initial treatment
Severe renal impairment (CrCl <30 mL/min) Not recommended Contraindicated Significantly increased bleeding risk

What Dosage Strengths Does Dabigatran Come In?

  • 75 mg capsules: Used for patients with moderate renal impairment or specific drug interactions
  • 110 mg capsules: Available in some countries; not commonly prescribed in the U.S.
  • 150 mg capsules: Standard strength for most adult patients

Missed Dose

If you miss a dose of Dabigatran, take it as soon as you remember on the same day. However, if it’s within 6 hours of your next scheduled dose, skip the missed dose and resume your regular schedule. Never take two doses at the same time to make up for a missed dose, as this increases bleeding risk.

Overdose

Taking too much Dabigatran significantly increases your risk of serious bleeding. If you suspect an overdose, seek emergency medical attention immediately. The specific reversal agent idarucizumab can be administered in hospital settings to reverse Dabigatran’s anticoagulant effects if life-threatening bleeding occurs.

Usage Guide

  • Swallow Dabigatran capsules whole with a full glass of water
  • Take with or without food, though taking with food may reduce stomach upset
  • Do not open, break, or chew the capsules, as this increases drug absorption and bleeding risk
  • Take doses approximately 12 hours apart for consistent blood levels
  • Remove capsules from the blister pack immediately before taking
  • Do not store capsules in pill organizers or other containers, as moisture exposure reduces effectiveness
  • Keep capsules in their original packaging until use to protect from humidity
  • Take at the same times each day to maintain steady anticoagulation
  • If you have difficulty swallowing, consult your healthcare provider about alternatives

Side Effects

The most common side effects include bleeding complications, stomach pain, indigestion, and nausea. More serious bleeding events require immediate medical attention.

  • Unusual bleeding or bruising
  • Blood in urine or stools (black, tarry, or red)
  • Severe headache or dizziness
  • Weakness or fatigue
  • Coughing up blood
  • Vomiting blood or material that looks like coffee grounds
  • Prolonged bleeding from cuts
  • Heavy or unusual menstrual bleeding

For detailed information on managing anticoagulant side effects, visit the National Blood Clot Alliance.

Warnings & Contraindications

  • Do not use if you have active pathological bleeding
  • Contraindicated in patients with mechanical prosthetic heart valves
  • Not recommended for severe renal impairment (CrCl <30 mL/min)
  • Increased bleeding risk when combined with antiplatelet agents or NSAIDs
  • Discontinue at least 24-48 hours before invasive procedures or surgery, depending on renal function
  • May not be suitable for patients with recent gastrointestinal bleeding
  • Avoid use during pregnancy unless clearly necessary
  • Spinal/epidural hematoma risk with neuraxial anesthesia or spinal puncture
  • Monitor for signs of bleeding, especially in elderly patients
  • Patients with moderate renal impairment require dose adjustment

Drug Interactions

  • NSAIDs (chronic use): Increases bleeding risk significantly
  • Antiplatelet agents (aspirin, clopidogrel): Enhanced bleeding potential
  • Other anticoagulants (warfarin, heparin): Additive anticoagulant effects
  • Rifampin: Reduces Dabigatran effectiveness; avoid concurrent use
  • Systemic ketoconazole: Increases Dabigatran levels; dose adjustment needed
  • Dronedarone: Requires dose reduction in patients with moderate renal impairment
  • P-gp inducers: May decrease Dabigatran exposure
  • Fibrinolytic therapy: Substantially increases bleeding risk

Storage Information

  • Store at room temperature between 15-30°C (59-86°F)
  • Keep capsules in original blister packaging until immediately before use
  • Protect from moisture and humidity
  • Do not transfer to pill organizers or other containers
  • Once opened, use blister card within 4 months
  • Keep out of reach of children and pets
  • Discard expired medication properly through medication take-back programs

Alternative Medications

  • Apixaban (brand name Eliquis): Factor Xa inhibitor with twice-daily dosing
  • Rivaroxaban (brand name Xarelto): Factor Xa inhibitor with once-daily dosing
  • Edoxaban (Savaysa): Factor Xa inhibitor for patients with specific conditions
  • Warfarin (sold as Coumadin): Traditional anticoagulant requiring regular INR monitoring
  • Enoxaparin (brand name Lovenox): Injectable anticoagulant for short-term use

Coupons

Use code FIRST10 at checkout and get 10% off your first Dabigatran order.

Savings on Bulk Purchases

Patients can maximize their savings by purchasing Dabigatran in larger quantities. The following pricing options are available:

Dabigatran 75 mg

Dosage Quantity Our Price (Canada) Average USA Price
75 mg 30 capsules $60 $107
75 mg 60 capsules $118 $214
75 mg 90 capsules $174 $321

Dabigatran 150 mg

Dosage Quantity Our Price (Canada) Average USA Price
150 mg 60 capsules $115 $214
150 mg 120 capsules $180 $428
150 mg 180 capsules $255 $642

Customer Support & Business Information

For questions regarding prescription processing, product availability, shipping timelines, or account support, contact Buy Canadian Insulin customer support:

Phone: 1-888-525-1815

Fax: 1-888-234-1275

Email: info@buycanadianinsulin.com

Customer Support Hours:

Monday-Friday: 7am – 10pm CST

Saturday & Sunday: 9am – 5pm CST

Business Address:

Buy Canadian Insulin

1026 Manitoba Avenue, Suite 1001

Selkirk, MB R1A 4M2

Canada

How to Order?

Step 1: Search for Dabigatran on our website, select the correct strength and quantity, then add it to your cart.

Step 2: Provide your contact information, shipping address, and payment details. Create an account if you’re a new customer or log in if you already have one.

Step 3: Upload your prescription directly to the site, email it to us, or fax it. Dabigatran requires a valid prescription, which our pharmacists will verify before processing your order.

Use FIRST10 to claim your 10% discount on your first order.

About Buy Canadian Insulin Services

Buy Canadian Insulin works with participating pharmacy partners to help patients access prescription medications and related healthcare products.

Product availability, pricing, and shipping timelines may vary depending on supplier inventory, participating pharmacy partner availability, and destination location.

Some prescription orders may be fulfilled through licensed pharmacy partners located in Canada or other international fulfillment locations depending on product availability.

Orders are packaged according to pharmacy handling and shipping procedures.

Have a prescription?

Order Dabigatran online today and enjoy a host of benefits, including:

  • Cost Savings: Buy Dabigatran at significantly lower prices than in the US prices
  • Bulk Order Discounts: Save more on bulk orders of Dabigatran (up to 90-day supply)
  • Reliable Express Shipping: Fast and discreet delivery shipped right to your doorstep
  • Exceptional Customer Service: Have a question? We’re delighted to help via live chat, email, or phone
  • Easy & Secure Ordering: Seamless online or phone ordering at 1-888-525-1815
  • SAVE 10% on first order with coupon code: FIRST10

Frequently Asked Questions

Yes, Dabigatran is classified as a direct oral anticoagulant (DOAC). Unlike traditional anticoagulants like warfarin, DOACs work by directly inhibiting specific clotting factors. Dabigatran specifically targets thrombin, making it a direct thrombin inhibitor within the DOAC category.
Dabigatran is pronounced “dah-BIG-ah-tran.” The brand name Pradaxa is pronounced “prah-DAX-ah.” Healthcare providers and pharmacists can help clarify pronunciation if you’re uncertain.
Common side effects include bleeding complications, stomach discomfort, indigestion, and nausea. Serious side effects involve unusual bleeding, blood in urine or stools, severe headaches, and prolonged bleeding from minor cuts. Contact your healthcare provider immediately if you experience signs of serious bleeding.
No, you should never crush, chew, or open Dabigatran capsules. The capsule coating controls drug release and absorption. Breaking the capsule significantly increases drug absorption, leading to dangerously high blood levels and increased bleeding risk. If you have difficulty swallowing capsules, discuss alternative anticoagulants with your healthcare provider.
Yes, bleeding is the most significant risk associated with Dabigatran, as with all anticoagulants. While the medication prevents dangerous blood clots, it also increases bleeding risk. Most patients tolerate Dabigatran well, but you should monitor for unusual bleeding and report any concerns to your healthcare provider promptly.
Dabigatran can affect INR test results, but INR monitoring isn’t used to measure Dabigatran’s anticoagulant effect. Unlike warfarin, which requires regular INR testing, Dabigatran provides predictable anticoagulation without routine monitoring. If INR testing is performed, results may be artificially elevated and shouldn’t guide dosing decisions.
Dabigatran typically doesn’t require bridging therapy when transitioning from other anticoagulants. The medication reaches therapeutic levels quickly, usually within 2 hours of the first dose. When switching from warfarin to Dabigatran, start Dabigatran once INR falls below 2.0. Your healthcare provider will determine the appropriate transition plan for your situation.
Most Medicare Part D plans cover Dabigatran, though coverage specifics vary by plan. Many plans place Dabigatran on higher formulary tiers, resulting in higher copayments. Ordering from Canada through Buy Canadian Insulin often costs less than U.S. Medicare copayments, even with insurance coverage.
Dabigatran is administered orally as a capsule taken twice daily. Swallow capsules whole with water, with or without food. Take doses approximately 12 hours apart for consistent anticoagulation. Never open, crush, or chew the capsules, as this alters drug absorption and increases bleeding risk.
Dabigatran undergoes minimal metabolism in the liver. After oral administration, the prodrug dabigatran etexilate converts to active dabigatran through esterase-catalyzed hydrolysis. The kidneys eliminate approximately 80% of the drug unchanged, making renal function crucial for proper dosing and safety.
Dabigatran’s elimination half-life ranges from 12-17 hours in patients with normal kidney function. Most of the drug clears from your system within 2-3 days after the last dose. However, patients with reduced kidney function may retain the medication longer, requiring extended discontinuation periods before surgery or procedures.
The duration for holding Dabigatran before surgery depends on your kidney function and bleeding risk of the procedure. For patients with normal kidney function undergoing standard-risk procedures, stop Dabigatran 24 hours before surgery. High-bleeding-risk procedures may require 48-96 hours of discontinuation. Your surgeon and prescribing physician will determine the appropriate timing for your specific situation.
Dabigatran costs vary significantly between the U.S. and Canada. U.S. prices typically range from $400-600 monthly, while Canadian prices through Buy Canadian Insulin range from $200-350 for the same quantity. Generic dabigatran etexilate offers additional savings while maintaining therapeutic equivalence to brand-name Pradaxa.
Unlike warfarin, Dabigatran doesn’t require routine blood monitoring for dosing adjustments. However, healthcare providers may check kidney function periodically, as renal impairment affects drug elimination. In specific situations requiring assessment of anticoagulant effect, specialized tests like diluted thrombin time or ecarin clotting time can be used.
Idarucizumab (Praxbind) is the specific reversal agent for Dabigatran, available in hospital settings for emergency situations. This monoclonal antibody fragment rapidly binds to Dabigatran, neutralizing its anticoagulant effect within minutes. For less urgent situations, simply discontinuing Dabigatran allows the drug to clear naturally within 2-3 days in patients with normal kidney function.
Yes, Dabigatran is a direct thrombin inhibitor. It works by directly and reversibly binding to thrombin, preventing the conversion of fibrinogen to fibrin and subsequent clot formation. This mechanism differs from other DOACs like apixaban and rivaroxaban, which inhibit Factor Xa rather than thrombin.
No, Dabigatran is not a Factor Xa inhibitor. While other DOACs like apixaban, rivaroxaban, and edoxaban work by inhibiting Factor Xa, Dabigatran targets thrombin directly. Both mechanisms effectively prevent blood clots but work at different points in the coagulation cascade.
Yes, Dabigatran etexilate is a prodrug. The medication you take orally is the inactive form (etexilate), which converts to active dabigatran in the body through esterase-catalyzed hydrolysis. This prodrug design improves oral absorption, though bioavailability remains relatively low at 3-7%.
Dabigatran is an anticoagulant, not an antiplatelet medication. Anticoagulants like Dabigatran prevent clot formation by inhibiting clotting factors in the coagulation cascade. Antiplatelet medications like aspirin or clopidogrel work differently by preventing platelet aggregation. Some patients may require both types of medications depending on their cardiovascular conditions.
Yes, dabigatran etexilate is the generic name for the brand-name medication Pradaxa. Both contain the same active ingredient in the same strengths and work identically in the body. Generic dabigatran etexilate offers the same therapeutic benefits as brand-name Pradaxa at a lower cost.

Disclaimer

Buy Canadian Insulin provides educational information about medications and health conditions for informational purposes only. This content is not intended to replace professional medical advice, diagnosis, or treatment. Prescription medications require valid prescription review and processing through participating pharmacy partners. Product availability, pricing, and shipping timelines may vary. Consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.

Price Match Guarantee

Price Match Guarantee

We’re dedicated to offering you the best value on every medication. If you discover a lower price on the same product at another verified Canadian online pharmacy, we’ll match it—so you can shop with confidence knowing you’re always getting a fair deal.

Eligibility Criteria

  • The pharmacy must be a licensed Canadian online provider with a verifiable address.
  • The competitor’s price must be active and current (not from past or upcoming promotions).
  • The product must match exactly in strength, pack size, quantity, manufacturer, and country of origin.
  • Requests must be made before completing your order—we cannot adjust prices after purchase.
  • Price matching does not apply to used or expired products.
  • Requests can be submitted via live chat or phone before checkout.

Note: Price matching does not currently apply to Mounjaro®, Ozempic®, or Saxenda®. This policy may be revised in the future.