- Cold-Chain Shipping Notice
- What is Eliquis?
- Indications and Benefits of Eliquis
- Fact Table
- How It Works
- Dosage
- Usage Guide
- Side Effects
- Missed Dose
- Overdose
- Storage Information
- Warnings & Precautions
- Contraindications
- Drug Interactions
- Alternative Medications
- Generic Alternative for Eliquis
- Cost & Ordering Information
- Frequently Asked Questions
- Disclaimer
- Price Match Guarantee
Cold-Chain Shipping Notice
This medication requires specialized cold-chain packaging to help maintain its quality and integrity during transit. Each shipment includes a temperature indicator to monitor storage conditions throughout the shipping process.
Do NOT use this medication if the attached temperature indicator shows that it was exposed to temperatures below 2°C (36°F) or above 8°C (46°F). If the temperature indicator shows that the acceptable temperature range has been exceeded, or if you have any concerns about the condition of your shipment upon arrival, do not use the medication and contact our pharmacy immediately for further instructions and assistance.
Please inspect your shipment and the temperature indicator as soon as it is delivered.
What is Eliquis?
Eliquis (apixaban) is a prescription anticoagulant medication and factor Xa inhibitor that helps prevent the formation of blood clots within a patient’s blood vessels, especially in the case of those who have had knee replacement surgery or total hip replacement surgery performed.
Additionally, Eliquis is used to treat and prevent deep vein thrombosis (DVT and pulmonary embolism (PE). It may also prevent both blood clots and strokes in those who have atrial fibrillation.
Indications and Benefits of Eliquis
Eliquis is prescribed for the prevention and treatment of blood clots associated with the following conditions:
- deep vein thrombosis (DVT)
- pulmonary embolism (PE)
It may also be prescribed for:
- The prevention of blood clots after hip replacement surgery
- The prevention of blood clots after knee replacement surgery
- The prevention of blood clots associated with atrial fibrillation
- The prevention of stroke associated with atrial fibrillation
What Are the Benefits of Eliquis?
- Eliquis helps lower the chance of stroke in people who have an irregular heartbeat called nonvalvular atrial fibrillation.
- Eliquis treats blood clots that form in the deep veins of the legs, known as deep vein thrombosis or DVT.
- It treats clots that travel to the lungs, which is called a pulmonary embolism or PE.
- Eliquis helps stop deep vein thrombosis and pulmonary embolism from happening again after the first treatment.
- It helps prevent blood clots in people who have had hip replacement surgery, lowering the risk of serious problems.
- Eliquis also helps prevent blood clots in people after knee replacement surgery.
Fact Table
| Fact Category | Fact Details |
| Generic Name | Apixaban |
| Medication Class | Anticoagulant |
| Primary Use | To lower the risk of stroke and blood clots in people with nonvalvular atrial fibrillation |
| Additional Benefit | Treats and helps prevent deep vein thrombosis and pulmonary embolism, especially after surgery |
| Available Form | Oral tablet |
| Method of Administration | Swallow the tablet with water |
| Frequency | Usually taken twice daily, based on condition and doctor’s instructions |
| Storage Instructions | Store at room temperature, away from light and moisture |
| Pregnancy and Breastfeeding | Use only if clearly needed and prescribed by a doctor; consult your doctor |
| Drug Interactions | May interact with other blood thinners, some antibiotics, antifungals, and other medications |
| Manufacturer | Bristol-Myers Squibb and Pfizer |
How It Works
Eliquis is an anticoagulant medication that functions by selectively inhibiting an enzyme (factor Xa) within the body that contributes to blood clotting.
By inhibiting this enzyme, Eliquis prevents factor Xa from generating thrombin and forming clots, reducing the risk of strokes, deep vein thrombosis, and pulmonary embolism.
Dosage
Eliquis is available in tablet form taken by mouth two times per day. Doses should be spaced approximately 12 hours apart. It may be taken with or without food and is acceptable to crush for easier administration. However, those who need to crush their tablet, should mix it with applesauce, apple juice, or water and be sure to consume it all at once.
Depending on the condition for which it has been prescribed, Eliquis may be used alongside additional medications or just by itself.
What Dosage Strengths Does Eliquis Come In?
Eliquis is available in tablet form and the following strengths:
- 2.5 mg
- 5 mg
Patients that are using Eliquis after having hip replacement surgery or knee replacement surgery will typically be prescribed a dose of 2.5 mg to be taken two times per day and 12 hours apart.
Most physicians require that their post-op patients take the first dose of Eliquis about 12 to 24 hours after they have had either of these surgeries.
Patients who are taking Eliquis after knee replacement surgery will typically remain using Eliquis to prevent blood clots for about two weeks. Those who have been prescribed Eliquis after hip replacement surgery will often need to continue using the medication for about 38 days after their procedure.
For the treatment of pulmonary embolism or deep vein thrombosis, the standard initial dose of Eliquis is 10 mg twice daily for seven days. After seven days, the dose is reduced to 5 mg of Eliquis twice daily for at least six months.
After any present clots in the patient have been successfully treated, your doctor may continue on a lower dose of 2.5 mg twice per day to prevent additional blood clots from developing.
Patients that have atrial fibrillation may be prescribed the 5 mg strength of Eliquis to be taken twice daily, 12 hours apart, to reduce the likelihood of experiencing blood clots or a stroke.
However, due to age and any additional health conditions an individual may have, some of these patients may be prescribed the lower dose of 2.5 mg for treatment.
Dosage Chart
| Population/Condition | Dose Strength | Frequency | Duration / Notes |
| NVAF (to lower risk of stroke and clots) | 5 mg | Twice daily | Standard dose |
| NVAF (if age age less than 80, body weight greater than 60 kg, or serum creatinine less than 1.5 mg/dL; at least 2 of these) | 2.5 mg | Twice daily | Lower dose for higher-risk patients |
| DVT or PE (initial treatment) | 10 mg | Twice daily | For first 7 days |
| DVT or PE (after first 7 days) | 5 mg | Twice daily | Continue after initial 7 days |
| Reducing risk of recurrent DVT/PE (after initial therapy) | 2.5 mg | Twice daily | At least after 6 months of treatment |
| DVT prevention after knee replacement surgery | 2.5 mg | Twice daily | For 12 days, start 12-24 hours after surgery |
| DVT prevention after hip replacement surgery | 2.5 mg | Twice daily | For 35 days, start 12-24 hours after surgery |
Usage Guide
Using Eliquis correctly is important to help prevent blood clots and reduce your risk of serious health problems. Follow your healthcare provider’s advice and read the instructions that come with your medication to get the best results and stay safe.
How do you take Eliquis?
- Read the patient information leaflet and usage guide from your pharmacist or healthcare provider before you start taking Eliquis.
- If you have questions or do not understand any part of the instructions, ask your doctor or healthcare provider for help.
- Your dose depends on your health condition, age, weight, other medications you take, and how your body responds to treatment.
- Take Eliquis by mouth two times a day, with or without food, just as your doctor tells you.
- Do not take more than your doctor tells you, do not take it more often, and do not use it for longer than recommended.
- If you are close to running out, contact your doctor or pharmacist so you do not miss a dose.
- If you have trouble swallowing tablets, you can crush them and mix them with water, apple juice, applesauce, or D5W solution.
- If you use a nasogastric tube, you can mix crushed tablets with 60 milliliters of water or D5W and give it through the tube.
- Do not stop taking Eliquis without talking to your doctor, as stopping suddenly can cause serious side effects.
- Take your doses at the same times each day to get the most benefit from your treatment.
- Tell your doctor if your condition does not improve or if you feel worse.
- Never share your medication with others, even if they have the same condition.
- Store Eliquis at room temperature in its original package, away from light, heat, and moisture.
Side Effects
Eliquis is associated with a number of common side effects, as well as some that may require medical attention, as they are signs that indicate a patient’s blood clotting proteins have been affected too strongly by the medication.
The most common side effects of taking Eliquis are as follows:
- anemia
- bruising
- fainting
- minor bleeding
- nausea
- skin rash
Some of the following more significant side effects may also occur, and these should be reported to your doctor immediately:
- black/tarry/bloody stools
- changes in menstrual flow (heavier than usual or lasting longer)
- coughing up blood
- dark-colored or pink urine
- difficulty swallowing
- dizziness
- excessive bleeding from one’s gums
- fainting
- frequent or persistent nosebleeds
- joint pain
- muscle weakness
- prolonged bleeding from any cuts
- severe headache
- unusual bruising
- unusual discomfort/pain
- unusual fatigue
- unusual swelling
- vomit that resembles coffee grounds
- vomiting blood
Please seek emergency medical attention immediately if you experience any of the following additional side effects:
- changes in vision
- confusion
- difficulty speaking
- weakness on one side of your body
Although very rare, allergic reactions may occur in some individuals when taking Eliquis. Seek emergency medical assistance if you experience any of the following symptoms of an allergic reaction:
- difficulty breathing
- extreme dizziness
- itching
- rash
- swelling of the throat, tongue, or face
Missed Dose
If you forget to take a dose of Eliquis, take it as soon as you remember. If it is almost time for your next dose, skip the missed one and go back to your regular schedule.
Do not take two doses at the same time to make up for the missed dose.
Try to take Eliquis at the same time every day, and consider setting a reminder on your phone to help you remember. This will help you get the most benefit from your treatment.
Overdose
Individuals who consume more than the recommended dose of Eliquis are at a significantly higher risk of bleeding. This risk level may be dangerously high depending on the amount of Eliquis that was consumed, and it may even be fatal in some circumstances.
If you or someone else has overdosed on Eliquis or taken a much higher dose than prescribed, medical attention should be sought immediately.
Storage Information
Eliquis tablets should be stored at room temperature and be kept away from moisture and light. This medication should not be stored in bathrooms.
Keep this medication out of the reach of children at all times.
When disposal of Eliquis tablets is required due to expiration or no longer needing them, these tablets should not be put down the sink, flushed down the toilet, or tossed into one’s household trash.
Please contact your prescribing physician or pharmacist for instructions regarding the safe and proper disposal of this medication.
Warnings & Precautions
Patients should be sure to discuss their medical history with their doctor before beginning treatment with Eliquis. This includes important information such as all current medications they may be taking as well as any preexisting health conditions to ensure that Eliquis is not contraindicated with any other aspects of your current health and treatment plans.
Certain Medical Conditions
If you have any of the following medical conditions, exercise caution when taking Eliquis and discuss your medical history with your doctor before beginning this medication, as many of these will significantly increase your risk of bleeding and serious side effects:
- any recent major injuries
- any recent major surgeries
- bleeding issues (in the brain or intestines/stomach)
- blood disorders (i.e., thrombocytopenia, hemophilia, anemia)
- clotting disorder (antiphospholipid syndrome)
- kidney disease
- liver disease
- prone to falling or becoming injured
- stroke
Alcohol Use
Due to Eliquis causing patients to be at an increased risk of experiencing stomach bleeding, it is strongly recommended that their intake of alcoholic beverages be limited while using the medication. People who consume alcohol on a regular basis should discuss this intake with their prescribing physician before beginning treatment with Eliquis.
Bleeding Risk
Eliquis is a blood thinner, and its use causes patients to have a significantly increased risk of bleeding. People who are using this medication should exercise extreme caution when engaging in any activities that involve sharp objects (e.g., shaving, using scissors, etc.), and they should also be cautious if engaging in contact sports. A mild head injury during such a sport requires immediate medical attention if the individual is taking anticoagulant medications. Eliquis will cause much easier bruising in those taking it, along with the increased risk of bleeding.
Epidural and Spinal Catheters
Eliquis should not be used in any patients who have an epidural or spinal catheter in place or for those who have had a catheter placed and removed within the past five hours. If a patient is receiving any type of pain medication through their catheter, Eliquis should not be used alongside those medications until five hours after the epidural or spinal catheter has been removed.
Pregnancy and Breastfeeding
Eliquis poses bleeding risks for a pregnant patient, the unborn baby, and also the newborn after it has been birthed. The patient’s doctor will determine whether the benefits of using Eliquis during pregnancy are worth the risks that also occur when using this medication. Based on the patient’s condition, an alternative medication may be more suited for use during pregnancy.
Additionally, it is not known whether Eliquis is passed into breast milk. Due to the lack of study regarding this potential risk, patients are not advised to use Eliquis while breastfeeding.
Surgery
Any patients taking Eliquis should be sure to inform their physicians or other health care professionals about using this medication before having surgery or having any dental work performed, as the use of Eliquis may contribute to heavy and potentially serious bleeding during these procedures.
Contraindications
Eliquis is not suitable for everyone. You should not use Eliquis if you have a history of allergic reactions to apixaban or any of its ingredients.
Tell your doctor if you have problems with your liver or kidneys, any history of bleeding in your stomach, intestines, or brain, or if you have blood disorders like anemia, hemophilia, or thrombocytopenia.
Also, let your doctor know if you have recently had major surgery, a serious injury, a history of stroke, or a condition called antiphospholipid syndrome. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor before starting Eliquis. If you are planning to have surgery or dental work, make sure to tell your doctor or dentist, as you may need to stop taking Eliquis for a short time.
Avoid drinking alcohol every day, as it can increase the risk of bleeding. Always share your full medical history and all products you take, including over-the-counter and herbal items, with your healthcare provider before starting Eliquis.
Drug Interactions
Speak to your doctor about any medications or herbal supplements you are currently taking before beginning treatment with Eliquis. Discuss any questions or concerns you may have with your doctor or a trusted pharmacist.
Drugs That Are Known to Interact with Eliquis
The following medications are known to interact with Eliquis and may increase your chances of experiencing adverse side effects:
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Drugs That Inhibit the Removal of Eliquis from the Body
The following medications may inhibit the removal of Eliquis from a patient’s body and impact the overall safety and efficacy of Eliquis:
- azole antifungals
- carbamazepine
- conivaptan
- HIV protease inhibitors
- itraconazole
- ketoconazole
- lopinavir
- phenytoin
- posaconazole
- rifabutin
- rifampin
- rifapatine
- ritonavir
- saquinavir
- seizure medications
- John’s wort
- voriconazole
Drugs That Increase the Bleeding Risk When Taking Eliquis
These medications may further increase a patient’s bleeding risk when taken in conjunction with Eliquis. Patients should be sure to check all medication labels carefully due to the common presence of the following:
- aspirin
- diclofenac
- ibuprofen
- naproxen
- NSAIDs
Patients who have been prescribed a low-dose aspirin regimen for the prevention of stroke or heart attack should be sure to discuss this with their prescribing physician and not stop their current aspirin regimen unless otherwise instructed to do so by their doctor.
Additionally, many herbal supplements may increase bleeding and should either not be taken with Eliquis or be used with caution. Please discuss the use of any of the following supplements with your physician before beginning treatment with Eliquis:
- cat’s claw
- chamomile
- dong quai
- garlic
- ginger
- ginseng
- John’s wort
Other Substances That May Interact with Eliquis
The following additional substances are also indicated to interact with Eliquis medication:
- grapefruit juice
Alternative Medications
For patients who are unable to take Eliquis or who are experiencing significant adverse side effects, alternative medications may be used to treat some of the associated conditions, which include:
- dabigatran (Pradaxa)
- edoxaban (Savaysa)
- heparin
- rivaroxaban (Xarelto)
- warfarin (Coumadin, Jantoven)
Generic Alternative for Eliquis
Apixaban is the active ingredient in Eliquis and may be available as a generic alternative through participating pharmacy partners. Product availability, manufacturer, packaging, and source may vary depending on the pharmacy partner and order details.
Generic alternatives may be offered at a lower cost than brand-name options. Pricing can vary based on strength, quantity, and pharmacy source.
Patients should speak with their healthcare provider or pharmacist before switching between brand-name Eliquis and an apixaban generic alternative.
Cost & Ordering Information
Buy Eliquis Through Buy Canadian Insulin
Buy Canadian Insulin helps patients access Eliquis through participating pharmacy partners.
Pricing may vary depending on product strength, quantity selected, supplier availability, and participating pharmacy partner pricing policies.
Some patients may find pricing through participating pharmacy partners that differs from certain U.S. retail pharmacy prices.
Available services may include:
- Pricing options based on quantity selected
- Prescription processing through participating pharmacy partners
- Shipping options available across eligible U.S. delivery locations
- Ordering support through phone, email, or live chat
- Multiple quantity options depending on prescription authorization and supplier availability
Eliquis requires a valid prescription. Prescription medications require review and approval by a licensed healthcare professional and pharmacist before dispensing, where applicable.
Shipping timelines may vary depending on prescription review requirements, inventory availability, destination location, customs review, and carrier services.
Eliquis (Brand Name) Pricing
| Strength | Quantity | Total Price (USD) | Price per Tablet | Avg. U.S. Price |
|---|---|---|---|---|
| 2.5mg | 60 tablets | $157.00 | $2.62 | $728.00 |
| 120 tablets | $308.00 | $2.57 | ||
| 180 tablets | $432.00 | $2.40 | ||
| 5mg | 60 tablets | $157.00 | $2.62 | $728.00 |
| 120 tablets | $308.00 | $2.57 | ||
| 180 tablets | $432.00 | $2.40 |
Generic Alternative (Apixaban) Pricing
| Strength | Quantity | Total Price (USD) | Price per Tablet | Avg. U.S. Price |
|---|---|---|---|---|
| 2.5mg | 60 tablets | $89.00 | $1.48 | $351.00 |
| 120 tablets | $170.00 | $1.42 | ||
| 180 tablets | $249.00 | $1.38 | ||
| 5mg | 60 tablets | $89.00 | $1.48 | $351.00 |
| 120 tablets | $170.00 | $1.42 | ||
| 180 tablets | $249.00 | $1.38 |
Generic Alternative Information
Apixaban is the active ingredient in Eliquis and may be available as a generic alternative through participating pharmacy partners.
Generic alternatives may contain the same active ingredient, but manufacturer, packaging, product source, and availability may vary.
Patients should consult their healthcare provider or pharmacist before switching between brand-name Eliquis and a generic apixaban product.
Prescription Medication Discounts and Coupons
Eligible customers may use coupon code ELIQUIS10 during checkout for qualifying Eliquis orders over $100, with a maximum discount of $50. Coupon availability and terms are subject to change.
Ordering Information
Have a Prescription?
Patients may explore available Eliquis prescription options through participating pharmacy partners.
Available ordering features may include:
- Pricing options based on quantity selected
- Multiple quantity options depending on prescription details
- Shipping options with tracking availability when provided by the carrier
- Customer support assistance through phone, email, or live chat
- Online and phone ordering availability
Pharmacist Consultation Availability
Licensed pharmacists may be available to answer questions regarding Eliquis, including dosage instructions, storage recommendations, possible side effects, and medication interactions.
Patients should consult their healthcare provider or pharmacist before starting, stopping, or changing Eliquis or any blood thinner medication.
Important Treatment Information
Eliquis is a blood thinner and may increase the risk of serious bleeding.
Patients should not stop taking Eliquis without speaking with their healthcare provider, as stopping treatment may increase the risk of blood clots or stroke.
Tell your healthcare provider right away if you notice unusual bleeding, black or bloody stools, blood in the urine, coughing or vomiting blood, severe headache, dizziness, weakness, or any signs of serious bleeding.
Patients should tell all healthcare providers, dentists, and surgeons that they take Eliquis before any procedure.
Customer Support & Pharmacy Information
For questions regarding your order, prescription processing, shipping, or medication information, contact Buy Canadian Insulin customer support:
Phone: 1-888-525-1815
Fax: 1-888-234-1275
Email: info@buycanadianinsulin.com
Customer Support Hours:
Monday-Friday: 7 am – 10 pm CST
Saturday & Sunday: 9 am – 5 pm CST
Business Address:
Buy Canadian Insulin
1026 Manitoba Avenue, Suite 1001
Selkirk, MB R1A 4M2
Canada
About Buy Canadian Insulin Services
Buy Canadian Insulin works with participating pharmacy partners to help patients access prescription medications and related healthcare products.
Product availability, pricing, and shipping timelines may vary depending on supplier inventory, participating pharmacy partner availability, and destination location.
Some prescription orders may be fulfilled through licensed pharmacy partners located in Canada or other international fulfillment locations depending on product availability.
Orders are packaged according to pharmacy handling and shipping procedures.
Frequently Asked Questions
Buying Eliquis from Canada
FDA-Prescription, Off-Label Information, and Limitations
Dosage & Administration
Adverse Reactions
Food & Drug Interactions
Storage & Travel
Drug Comparison
Disclaimer
Buy Canadian Insulin provides educational information about medications and health conditions for informational purposes only. This content is not intended to replace professional medical advice, diagnosis, or treatment. Prescription medications require valid prescription review and processing through participating pharmacy partners. Product availability, pricing, and shipping timelines may vary. Consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
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