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Eliquis (apixaban) is a prescription anticoagulant medication and factor Xa inhibitor that helps prevent the formation of blood clots within a patient’s blood vessels, especially in the case of those who have had knee replacement surgery or total hip replacement surgery performed. Additionally, Eliquis may be used in the treatment and prevention of blood clots in those who have a pulmonary embolism or deep vein thrombosis. It may also prevent both blood clots and strokes in those who have atrial fibrillation.

How is Eliquis Used?

Eliquis is available in tablet form taken orally twice per day. There should be a period of 12 hours between each dose. It may be taken with or without food, and  acceptable to crush for easier consumption. However, those who need to crush their tablet, should mix it with applesauce, apple juice, or water and be sure to consume it all at once.

Depending on the condition for which it has been prescribed, Eliquis may be used alongside additional medications or just by itself.


Eliquis tablets should be stored at room temperature and be kept away from moisture and light. This medication should not be stored in one’s bathroom.

Keep this medication out of the reach of children at all times.

When disposal of Eliquis tablets is required due to expiration or no longer needing them, these tablets should not be put down the sink, flushed down the toilet, or tossed into one’s household trash. Please contact your prescribing physician or pharmacist for instructions regarding the safe and proper disposal of this medication.


Eliquis is prescribed for the prevention or treatment of blood clots associated with the following conditions:

  • deep vein thrombosis (DVT)
  • pulmonary embolism (PE)

It may also be prescribed for:

  • the prevention of blood clots after hip replacement surgery
  • the prevention of blood clots after knee replacement surgery
  • the prevention of blood clots associated with atrial fibrillation
  • the prevention of stroke associated with atrial fibrillation

How Does Eliquis Work?

Eliquis is an anticoagulant medication that functions by inhibiting an enzyme within the body that contributes to blood clotting. As a factor Xa (FXa) inhibitor, it prevents FXa from performing its function, and this reduces the production of the substances within a patient’s body that results in blood being able to clot. By doing this, the patient’s blood becomes thinner, and their risk of blood clots and stroke is lowered.


Eliquis is available in tablet form and in the following strengths:

  • 2.5 mg
  • 5 mg

Patients that are using Eliquis after having hip replacement surgery or knee replacement surgery will typically be prescribed a dose of 2.5 mg to be taken two times per day and 12 hours apart. Most physicians require that their post-op patients take the first dose of Eliquis about 12 to 24 hours after they have had either of these surgeries. Patients who are taking Eliquis after knee replacement surgery will typically remain using Eliquis to prevent blood clots for about two weeks. Those who have been prescribed Eliquis after hip replacement surgery will often need to continue using the medication for about 38 days after their procedure.

For the treatment of pulmonary embolism or deep vein thrombosis, the most commonly prescribed dose of Eliquis is 10 mg twice daily for the duration of a week. After seven days, this will likely be reduced to just 5 mg of Eliquis twice daily for about six months. After any present clots in the patient have been successfully treated, they will usually remain on a lowered dose of 2.5 mg twice per day to continue managing their condition and to prevent additional blood clots from developing.

Patients that have atrial fibrillation may be prescribed the 5 mg strength of Eliquis to be taken twice daily, 12 hours apart, to reduce the likelihood of experiencing blood clots or a stroke. However, due to age and any additional health conditions an individual may have, some of these patients may be prescribed the lower dose of 2.5 mg for treatment.


Individuals that consume more than the recommended dose of Eliquis are at a significantly higher risk of bleeding. This risk level may be dangerously high depending on the amount of Eliquis that was consumed, and it may even be fatal in some circumstances.

If you or someone else has overdosed on Eliquis or taken a much higher dose than prescribed, medical attention should be sought immediately.

Side Effects

Eliquis is associated with a number of common side effects, as well as some that may require medical attention, as they are signs that indicate a patient’s blood clotting proteins have been affected too strongly by the medication.

The most common side effects of taking Eliquis are as follows:

  • anemia
  • bruising
  • fainting
  • minor bleeding
  • nausea
  • skin rash

Some of the following more significant side effects may also occur, and these should be reported to your doctor immediately:

  • black/tarry/bloody stools
  • changes in menstrual flow (heavier than usual or lasting longer)
  • coughing up blood
  • dark-colored or pink urine
  • difficulty swallowing
  • dizziness
  • excessive bleeding from one’s gums
  • fainting
  • frequent or persistent nosebleeds
  • joint pain
  • muscle weakness
  • prolonged bleeding from any cuts
  • severe headache
  • unusual bruising
  • unusual discomfort/pain
  • unusual fatigue
  • unusual swelling
  • vomit that looks like coffee grounds
  • vomiting blood

Please seek emergency medical attention immediately if you experience any of the following additional side effects:

  • changes in vision
  • confusion
  • difficulty speaking
  • weakness on one side of your body

Although very rare, allergic reactions may occur in some individuals when taking Eliquis. Seek emergency medical assistance if you experience any of the following symptoms of an allergic reaction:

  • difficulty breathing
  • extreme dizziness
  • itching
  • rash
  • swelling of the throat, tongue, or face

Warnings & Precautions

Patients should be sure to discuss their medical history with their doctor before beginning treatment with Eliquis. This includes important information such as all current medications they may be taking as well as any preexisting health conditions to ensure that Eliquis is not contraindicated with any other aspects of your current health and treatment plans.

Certain Medical Conditions

If you have any of the following medical conditions, exercise caution when taking Eliquis and discuss your medical history with your doctor before beginning this medication, as many of these will significantly increase your risk of bleeding and serious side effects:

  • any recent major injuries
  • any recent major surgeries
  • bleeding issues (in the brain or intestines/stomach)
  • blood disorders (i.e., thrombocytopenia, hemophilia, anemia)
  • clotting disorder (antiphospholipid syndrome)
  • kidney disease
  • liver disease
  • prone to falling or becoming injured
  • stroke

Alcohol Use

Due to Eliquis causing patients to be at an increased risk of experiencing stomach bleeding, it is strongly recommended that their intake of alcoholic beverages be limited while using the medication. People that consume alcohol on a regular basis should discuss this intake with their prescribing physician before beginning treatment with Eliquis.

Bleeding Risk

Eliquis is a blood thinner, and its use causes patients to have a significantly increased risk of bleeding. People that are using this medication should exercise extreme caution when engaging in any activities that involve sharp objects (e.g., shaving, using scissors, etc.), and they should also be cautious if engaging in contact sports. A mild head injury during such a sport requires immediate medical attention if the individual is taking anticoagulant medications. Eliquis will cause much easier bruising in those taking it, along with the increased risk of bleeding.

Epidural and Spinal Catheters

Eliquis is not safe for use in any patients who have an epidural or spinal catheter in place or for those who have had such a catheter placed and removed within the past five hours. If a patient is receiving any type of pain medication through their catheter, Eliquis should not be used alongside those medications until five hours after the epidural or spinal catheter has been removed.

Pregnancy and Breastfeeding

Eliquis poses bleeding risks for a pregnant patient, the unborn baby, and also the newborn after it has been birthed. The patient’s doctor will determine whether the benefits of using Eliquis during pregnancy are worth the risks that also occur when using this medication. Based on the patient’s condition, an alternative medication may be more suited for use during pregnancy.

Additionally, it is not known whether Eliquis is passed into breast milk. Due to the lack of study regarding this potential risk, patients are not advised to use Eliquis while breastfeeding.


Any patients taking Eliquis should be sure to inform their physicians or other health care professionals about using this medication before having surgery or having any dental work performed, as the use of Eliquis may contribute to heavy and potentially serious bleeding during these procedures.

Drug Interactions

Speak to your doctor about any medications or herbal supplements you are currently taking before beginning treatment with Eliquis. Discuss any questions or concerns you may have with your doctor or a trusted pharmacist.

Drugs That Are Known to Interact with Eliquis

The following medications are known to interact with Eliquis and may increase your chances of experiencing adverse side effects:

  • acetylsalicylic acid (ASA)
  • aminosalicylic acid
  • amlodipine
  • antidepressants
  • antiplatelet medications
  • aprepitant
  • blood thinners
  • bosentan
  • calcium channel blockers
  • carbamazepine
  • citalopram
  • clarithromycin
  • clopidogrel
  • conjugated estrogen
  • crizotinib
  • cyclosporine
  • dabigatran
  • dabrafenib
  • dalteparin
  • dasatinib
  • deferasirox
  • delavirdine
  • desipramine
  • dexamethasone
  • desvenlafaxine
  • dienogest
  • diltiazem
  • dipyridamole
  • dronedarone
  • duloxetine
  • edoxaban
  • efavirenz
  • enoxaparin
  • enzalutamide
  • erythromycin
  • estrogen
  • estradiol
  • ethinyl estradiol
  • etravirine
  • fluoxetine
  • heparin
  • HIV non-nucleoside reverse transcriptase inhibitors
  • imatinib
  • levonorgestrel
  • lomitapide
  • low-molecular-weight heparins
  • lumacaftor
  • macrolide antibiotics
  • medroxyprogesterone
  • mifepristone
  • mitotane
  • modafinil
  • nefazodone
  • nevirapine
  • nifedipine
  • NNRTIs
  • norethindrone
  • norfloxacin
  • obinutuzumab
  • omega-3 fatty acids
  • oxcarbazepine
  • paroxetine
  • phenobarbital
  • prasugrel
  • primidone
  • progestins
  • rivaroxaban
  • sertraline
  • siltuximab
  • SNRIs
  • SSRIs
  • tetracycline
  • ticagrelor
  • ticlopidine
  • tinzaparin
  • tocilizumab
  • tyrosine kinase inhibitors
  • venlafaxine
  • verapamil
  • vitamin E
  • warfarin

Drugs That Inhibit the Removal of Eliquis from the Body

The following medications may inhibit the removal of Eliquis from a patient’s body and impact the overall safety and efficacy of Eliquis:

  • azole antifungals
  • carbamazepine
  • conivaptan
  • HIV protease inhibitors
  • itraconazole
  • ketoconazole
  • lopinavir
  • phenytoin
  • posaconazole
  • rifabutin
  • rifampin
  • rifapatine
  • ritonavir
  • saquinavir
  • seizure medications
  • John’s wort
  • voriconazole

Drugs That Increase the Bleeding Risk When Taking Eliquis

These medications may further increase a patient’s bleeding risk when taken in conjunction with Eliquis. Patients should be sure to check all medication labels carefully due to the common presence of the following:

  • aspirin
  • diclofenac
  • ibuprofen
  • naproxen
  • NSAIDs

Patients that have been prescribed a low-dose aspirin regimen for the prevention of stroke or heart attack should be sure to discuss this with their prescribing physician and not stop their current aspirin regimen unless otherwise instructed to do so by their doctor.

There are also many herbal supplements that may increase bleeding and should either not be taken with Eliquis or be used with caution. Please discuss the use of any of the following supplements with your physician before beginning treatment with Eliquis:

  • cat’s claw
  • chamomile
  • dong quai
  • garlic
  • ginger
  • ginseng
  • John’s wort

Other Substances That May Interact with Eliquis

The following additional substances are also indicated to interact with Eliquis medication:

  • grapefruit juice

Alternative Medications

For patients who are unable to take Eliquis or experiencing significant adverse side effects, alternative medications may be used to treat some of the associated conditions for which this medication is commonly prescribed:

  • dabigatran (Pradaxa)
  • edoxaban (Savaysa)
  • heparin
  • rivaroxaban (Xarelto)
  • warfarin (Coumadin, Jantoven)

Cost & Discounts

Eliquis Savings

At Buy Canadian Insulin, we understand the financial challenges associated with securing necessary medications. That’s why we offer Eliquis at significantly lower prices than what you might encounter in the U.S. For instance, Eliquis 2.5mg with a quantity of 60 tablets, which can cost over $700 stateside, is available through us for just $157. Moreover, patients looking to maximize their savings can benefit from ordering in bulk. For example, purchasing Eliquis 2.5mg with a quantity of 180 tablets will cost only $432.

Special Coupon Offer

To make your purchase even more affordable, we’re offering a special coupon: use code ELIQUIS10 on orders with a minimum spend of $100 to enjoy up to $50 off. This offer is designed to help ease the financial burden of managing your health, allowing each patient to use the coupon once.

How to Order

Ordering Eliquis from Buy Canadian Insulin is a straightforward process that ensures you get the medications you need without the exorbitant costs associated with U.S. pharmacies. Our platform is designed to provide a hassle-free experience, ensuring you can focus on what truly matters – your health.

Remember, while the cost of medication can be high, your health is invaluable. With Buy Canadian Insulin, you can manage your medication needs affordably and efficiently.

Buy Generic Eliquis from Canada

You don’t have to wait until 2026 to access generic versions of Eliquis. These generic versions are available from other sources, as the rules governing U.S. drug patents may not apply in other countries. While generic Eliquis is not yet available for sale in the United States, however, you can start saving now by purchasing it from a reputable source such as an online Canadian Pharmacy partner such as Buy Canadian Insulin.

It’s worth noting that the cost of the generic form of Eliquis (apixaban) from Canada is more affordable when compared to the price of the brand.One reason is that the Canadian government regulates the prices of prescription drugs, including Eliquis, to ensure that they are affordable for consumers. The government uses a number of methods to control drug prices, such as negotiating directly with pharmaceutical companies and setting maximum prices for certain drugs. As a result, the price of Eliquis in Canada is often lower than it is in the United States.

The importance of Generic Eliquis

The availability of generic Eliquis through an online Canadian pharmacy is a significant development because it allows at-risk patients to access one of the most effective and popular anticoagulants at a lower cost. Several factors, including the drug’s effectiveness, demand, and regulations, contribute to the high price of brand-name Eliquis. However, the availability of generic Eliquis can help bridge the gap for patients who are concerned about the cost of this medication. Generic Eliquis offers the same benefits as the brand-name version but at a fraction of the cost, thanks to the research and development that has gone into the drug.

In addition to the cost savings, the availability of generic Eliquis is valuable to many American patients as it provides earlier access to a generic equivalent option. As mentioned, generic versions of Eliquis are not expected to be available in the United States until 2026 at the earliest. The ability to easily access this life-saving medication can make a significant difference. Clinical studies have shown that Eliquis, also known as apixaban, is more effective at preventing blood clots and stroke than warfarin, and it does not increase the risk of bleeding. With its quick onset time and cost-effective generic option, it offers numerous benefits without straining your budget.

Frequently Asked Questions

The price of Eliquis (2mg and 5mg) and the generic equivalent (apixaban) is available at the following prices:

Eliquis (apixaban) 2.5mgGeneric equivalent (apixaban) 2.5mg
60 tablets$157$77
120 tablets$308$152
180 tablets$432$225

*Prices are subject to change. To get the current price, reference the product dropdown above.

Eliquis begins to work relatively quickly after administration. The exact onset time can vary, but it generally starts to take effect within a few hours of taking the dose. Patients should follow their healthcare provider’s instructions regarding the timing and administration of Eliquis.

Patients can save 10% on their first order of Eliquis with coupon code: FIRST10

Yes, a prescription is required to buy Eliquis (apixaban) from Canada. Prescriptions can be sent via email, fax or uploaded through the patient dashboard.

Eliquis is available in several different strengths, typically expressed in milligrams (mg). The strengths of the tablets that are commonly available in:

  • 2.5 mg (milligrams)
  • 5 mg (milligrams)

These are the standard strengths of Eliquis tablets that are prescribed for various indications. The specific strength and dosage regimen prescribed to an individual patient may vary based on their medical condition, age, weight, and other factors. It is important to follow the dosage instructions provided by your healthcare professional and only take the prescribed strength.

Eliquis can be taken with or without food. It’s important for patients to follow their healthcare provider’s instructions regarding the administration of Eliquis to ensure its effectiveness and safety.

Yes, there is a therapeutically equivalent generic alternative to Eliquis available. The generic version, known as apixaban, can be purchased through Buy Canadian Insulin, offering significant savings compared to the brand-name medication. The availability of generic Eliquis (apixaban) from Canada provides an affordable option for American patients requiring this medication.

Eliquis is considered a blood thinning medication that helps to prevent the formation of blood clots within a patient’s body.

In some cases, patients using Eliquis should continue treatment with the medication for about three to six months before it is safe for them to stop using it. However, in other cases, a patient may need to use Eliquis for the long term to manage their condition.

It has not been determined whether Eliquis is safe for use in individuals below the age of 18 years. Eliquis is typically not prescribed for any patients that fall into the child or adolescent age groups.

The blood thinning effects of Eliquis will often fade away within about one day after your last dose of medication.

Eliquis should not make a patient feel cold. However, some individuals have reported an increased tendency to feel cold after using the medication.

Eliquis tablets contain the following ingredients: anhydrous lactose, croscarmellose sodium, magnesium stearate, microcrystalline cellulose, and sodium lauryl sulfate. The coating on these tablets includes the following ingredients: hypromellose, lactose monohydrate, triacetin, titanium dioxide, and red iron oxide (for the 5 mg tablets) or yellow iron oxide (for the 2.5 mg tablets).

Although Eliquis itself has not been reported to cause tiredness in patients using the medication, feeling tired is a common symptom associated with anemia and blood loss. If you begin to feel unusually tired after beginning treatment with this medication, please speak to your prescribing physician to ensure that your fatigue is not due to internal bleeding.

Eliquis is generally cheaper in Canada due to different pharmaceutical pricing regulations. In Canada, the government negotiates the price for medications like Eliquis through regulatory boards, which often results in lower prices compared to the U.S. Additionally, Canadian online pharmacies provide access to global options that offer significant savings.

If a dose of Eliquis is missed, it should be taken only on the same day as soon as it is remembered. The next dose should be taken at the regular time, and the medication should continue to be taken twice daily. Patients should avoid taking two doses of Eliquis at the same time.

Patients taking Eliquis should consult with their healthcare provider regarding alcohol consumption. While moderate alcohol intake may be permissible, excessive alcohol use can increase the risk of bleeding. It’s important to follow the doctor’s advice and guidelines when combining Eliquis with alcohol.

The duration of Eliquis treatment depends on the individual patient’s medical condition and the doctor’s recommendation. It’s important to follow the healthcare provider’s instructions and not stop taking Eliquis without medical advice. The duration of treatment can vary based on the patient’s needs and response to the medication.

In 2019, the FDA approved generic versions of Eliquis, but they are not available for sale in the United States due to a patent held by Bristol-Meyers Squibb and Pfizer, which allows them to sell the drug exclusively until November 2026. However, with a prescription, a generic equivalent to Eliquis is available through our website at low prices.