Cold-Chain Shipping Notice
This medication requires specialized cold-chain packaging to help maintain its quality and integrity during transit. Each shipment includes a temperature indicator to monitor storage conditions throughout the shipping process.
Do NOT use this medication if the attached temperature indicator shows that it was exposed to temperatures below 2°C (36°F) or above 8°C (46°F). If the temperature indicator shows that the acceptable temperature range has been exceeded, or if you have any concerns about the condition of your shipment upon arrival, do not use the medication and contact our pharmacy immediately for further instructions and assistance.
Please inspect your shipment and the temperature indicator as soon as it is delivered.
What is Entuzity KwikPen?
Entuzity KwikPen (human insulin) helps people with type 1 and type 2 diabetes manage their blood sugar levels.
Pharmaceutical experts create this insulin in a lab using advanced technology that copies the human insulin gene.
Each milliliter of Entuzity KwikPen holds 500 units of insulin. In comparison, most other insulin types have only 100 units per milliliter.
Due to its strength, Entuzity is suitable for individuals who require more than 200 units of insulin per day. It is not suitable for children or adults over 75 years old unless a doctor provides specific guidance.
Entuzity works well for those who require higher insulin doses and cannot control their blood sugar with standard insulin.
A doctor will determine if Entuzity is suitable for your health condition and insulin needs. Follow the prescribed instructions at all times.
Indications and Benefits of Entuzity KwikPen
Entuzity KwikPen is an FDA-approved insulin pen designed for adults with type 1 or type 2 diabetes who need high-dose insulin therapy.
Studies show that this option is best for people who need higher insulin doses and cannot manage their diabetes with regular insulin.
Entuzity is not meant for use with other types of insulin and does not treat emergencies such as diabetic ketoacidosis or diabetic coma.
Benefits of Entuzity KwikPen
- Entuzity delivers a stronger insulin dose in a smaller injection volume, making it ideal for individuals with high daily insulin requirements.
- It reduces the number of daily injections needed for individuals who require large insulin doses.
- It helps control blood sugar spikes during meals and maintains more stable glucose levels throughout the day.
- The prefilled KwikPen offers convenience and ease of use, as it does not require mixing or drawing insulin from a vial.
- It simplifies treatment for those who find it difficult to manage multiple injections or follow complex insulin regimens.
- Smaller injection volumes cause less discomfort, making the daily insulin routine more comfortable.
- Better blood glucose control may lower the risk of long-term complications, including nerve damage, kidney problems, and vision loss.
- It supports a more manageable and consistent diabetes care plan for individuals with advanced insulin needs.
How It Works
Entuzity KwikPen helps lower blood sugar in two ways. First, it works right after meals to bring down the spike in blood sugar levels.
This is called mealtime insulin. Second, it keeps blood sugar steady between meals and while you sleep. This is known as basal or background insulin.
Most people use Entuzity two or three times a day with meals. It gives both fast and long-lasting effects to help manage type 1 or type 2 diabetes.
Since Entuzity is a strong form of insulin, it should not be mixed with other types of insulin or used in an insulin pump.
Entuzity supports better blood sugar control by combining the benefits of mealtime and background insulin in one convenient pen. Always follow your doctor’s instructions to use it safely and effectively.
Dosage
The dosage of Entuzity KwikPen depends on how high your blood sugar is, how active you are, and your overall health condition.
Your doctor will decide how much insulin you need each day. Most people take it two or three times daily before meals.
You must always use a new needle for each injection and never share your pen with anyone to avoid infection or wrong dosage. Use Entuzity exactly as your doctor tells you.
Dosage Form and Strengths of Entuzity KwikPen
Entuzity KwikPen comes as a prefilled pen with 500 units of insulin in each milliliter. This is a highly concentrated insulin, designed for individuals who require large doses. Each pen holds 3 milliliters, which means 1,500 units of insulin per pen.
You can take doses starting at five units and go up in steps of 5 units, up to a maximum of 300 units in one injection.
You should only inject Entuzity under the skin. Never inject it into a vein or muscle. Do not use it with insulin pumps, and avoid mixing it with other types of insulin.
Recommended Dosage
| Patient Group or Condition | Recommended Dosage | Important Notes |
| Adults needing over 200 units per day | 2 or 3 injections daily, 30 minutes before meals | The doctor will decide based on the blood sugar needs |
| Twice-daily injection schedule | 60% of the total dose before breakfast, 40% before dinner | Helps balance daytime and evening sugar levels |
| Three-times-daily injection schedule | 40% before breakfast, 30% before lunch, 30% before dinner | Offers more precise control for each meal |
| Switching from another insulin (HbA1c 8 percent or less) | Reduce total daily insulin dose by 20 percent | Helps prevent low blood sugar when switching |
| Switching from another insulin (HbA1c over 8 percent) | Use the same total daily insulin dose (unit-to-unit) | Your doctor may fine-tune after checking your response |
| During illness, lifestyle, or diet changes | Adjust the dosage as needed under a doctor’s supervision | Blood sugar may rise or fall with stress or changes |
| Older adults (65 to 75 years old) | Use with caution and close monitoring | Greater risk of low blood sugar; doctor must monitor closely |
| Children under 18 or adults over 75 | Not studied or approved for regular use unless specifically advised by a doctor. | Use only if the doctor decides the benefits outweigh the risks. |
Usage
Using the Entuzity KwikPen the right way is important for safe and effective blood sugar control.
This prefilled insulin pen is made only for Entuzity and delivers a high concentration of insulin.
Before each use, check the label and follow proper steps to make sure you inject the correct dose. Always use the pen exactly as your doctor tells you.
How to administer Entuzity KwikPen?
Use Entuzity KwikPen two or three times daily, 30 minutes before meals. Inject the insulin under your skin (subcutaneous injection) in areas like the abdomen, thigh, upper arm, or buttock.
Do not inject into a vein or muscle. Avoid using an insulin pump with this pen, and never mix Entuzity with other types of insulin or liquids.
Always rotate your injection sites to avoid lumps or skin thickening. Check your blood sugar regularly as advised by your doctor.
Never share your pen or needle with anyone, and do not reuse needles, as this can lead to infections or wrong insulin doses.
Steps on Administering Entuzity KwikPen
- Wash your hands with soap and water to keep the injection clean and reduce the risk of infection.
- Take the pen out of the fridge if it is new and let it warm to room temperature for about 30 minutes before use.
- Check the label to make sure it says Entuzity and confirm that it is the correct insulin.
- Look at the insulin through the pen window. It should be clear and colorless. Do not use it if it appears cloudy or contains particles.
- Remove the cap from the pen and attach a new sterile needle.
- Prime the pen by dialing five units and pressing the injection button until insulin appears at the tip of the needle. This helps remove air bubbles.
- Turn the dose dial to the number of units prescribed by your doctor. Read the number in the dose window and do not count clicks.
- Choose your injection site and clean it with an alcohol swab.
- Gently pinch the skin and insert the needle straight into the area beneath the skin.
- Press the injection button down and hold it there for 5 to 10 seconds to make sure you receive the full dose.
- Remove the needle from your skin and check the site to make sure no insulin is leaking.
- Remove the needle from the pen and dispose of it in a sharps container.
- Put the cap back on the pen and store it as directed by your healthcare provider.
- Rotate injection sites with each dose to help avoid skin damage or irritation.
- Monitor your blood sugar levels as recommended and record the results if needed. Only adjust your dosage or routine as directed by your doctor.
Side Effects
Entuzity KwikPen may cause side effects. Some are mild and common, while others can be more serious and require immediate medical help.
Most side effects involve low blood sugar or skin reactions at the injection site. Consult your doctor if side effects persist.
Common side effects
These side effects are typically mild and often subside over time. Still, let your doctor know if they do not improve:
- Low blood sugar (hypoglycemia), which may cause sweating, hunger, shakiness, or dizziness
- Redness, swelling, or itching at the injection site
- Skin rash or irritation
- Thickening or small dents in the skin where insulin is injected
- Headache or tiredness
- Fast heartbeat
- Cold sweat or nervousness
- Weight gain due to fluid buildup or changes in insulin balance
Severe side effects
These side effects are less common but can be dangerous. Seek medical attention right away if any of the following occur:
- Severe low blood sugar causing confusion, fainting, or seizures
- Allergic reactions such as full-body rash, swelling of the face or throat, or trouble breathing
- Fast or irregular heartbeat with low blood pressure
- Diabetic ketoacidosis, a serious condition with fruity-smelling breath, nausea, heavy breathing, and dry skin
- Sudden weight gain or swelling in the legs, feet, or ankles
- Trouble seeing clearly or concentrating
- Drowsiness or feeling very tired
- Unusual swelling or hard lumps at the injection site
- Localized cutaneous amyloidosis (a rare skin reaction causing firm bumps at repeated injection sites)
Missed Dose
Missing a dose of Entuzity KwikPen may cause your blood sugar level to rise above normal. This can make you feel thirsty, tired, or cause you to urinate more frequently. If you forget to take a dose, check your blood sugar as soon as you can.
Keep monitoring it throughout the day. Do not take more insulin to make up for the missed dose.
Taking extra insulin can drop your blood sugar too low and lead to serious problems. If you are unsure about what to do next, consult with your doctor or healthcare team immediately.
Overdose
Taking too much Entuzity KwikPen can lead to a sudden drop in blood sugar, known as hypoglycemia. This may cause symptoms like feeling shaky, weak, confused, dizzy, or sweaty.
If you think you have taken too much insulin, check your blood sugar immediately. If it is low, eat or drink something sweet, such as juice or a glucose tablet.
Keep a fast sugar source nearby in case of emergencies. If you feel very sick, confused, or unable to treat yourself, get medical help right away.
Warnings
- Severe hypoglycemia can occur suddenly. Watch for early signs, such as sweating, shakiness, dizziness, a fast heartbeat, or confusion.
- Do not mix Entuzity with other types of insulin or inject it through a pump or vein. This can cause dangerous drops in blood sugar.
- Never draw insulin from the Entuzity KwikPen into a syringe. This may cause dosing mistakes and lead to an overdose.
- Always confirm the insulin label, strength, and dose before each injection to avoid serious medication errors.
- Use Entuzity only if the liquid is clear and colorless. Do not use it if you see particles or cloudiness.
- Never share your pen with anyone, even if the needle is changed. Sharing can spread infections.
- Change your injection site regularly. Repeating injections in the same area can cause skin thickening or lumps.
- Do not change your insulin brand, type, dose, or injection method without talking to your doctor. Changes may cause blood sugar to go too high or too low.
- Monitor your blood sugar more frequently during illnesses, periods of stress, lifestyle changes, or when starting a new medication. These can affect how your body responds to insulin.
- Low potassium levels may occur with an overdose. This can affect heart rhythm and should be checked by your doctor if needed.
- Watch for allergic reactions, such as rash, swelling, or trouble breathing. Seek medical attention immediately if this occurs.
- Older adults or people with kidney, liver, thyroid, or hormone-related conditions may need special dose adjustments.
- Entuzity may not be suitable for people with adrenal or thyroid disorders. These conditions can affect insulin needs.
- If pregnant or breastfeeding, use Entuzity only with your doctor’s guidance. Insulin needs may change during this time.
- Children may use Entuzity, but only under a doctor’s care with personalized dosing.
- Some people may not feel warning signs of low blood sugar, especially if they have long-term diabetes or have recently changed insulin.
- Be cautious when driving or operating machinery, especially if you have experienced very high or very low blood sugar levels. These can affect your ability to focus.
Boxed Warning and Precautions for Entuzity KwikPen
| Entuzity KwikPen is a concentrated insulin that contains five times more insulin per milliliter than regular insulin, so it must be used with extra care.
The biggest risk is severe low blood sugar, which can happen suddenly and may lead to fainting, unconsciousness, or even death if not treated right away. Never mix Entuzity with other insulins, use it in an insulin pump, or draw it into a syringe, as these actions can cause dangerous dosing errors. Always check that the liquid is clear and confirm your dose before every injection. Do not switch from other insulins to Entuzity unless your doctor specifically tells you to, because it is not interchangeable. Any changes in your insulin treatment should only be made under medical supervision to avoid serious health risks. |
Contraindications
You should not use Entuzity KwikPen in certain situations, as it may cause serious harm. Make sure to review these conditions before starting treatment and talk to your doctor if you are unsure.
- Do not use Entuzity if you have a known allergy to insulin or any of the ingredients in the pen. Allergic reactions may include rash, swelling, or difficulty breathing.
- Do not use Entuzity during episodes of low blood sugar, also called hypoglycemia. This can make the condition worse and lead to dangerous complications.
Interactions
Entuzity KwikPen can interact with certain drugs and affect how your body controls blood sugar.
Some drugs may cause blood sugar to drop too low (hypoglycemia), while others may raise it too high (hyperglycemia).
These changes can lead to serious problems if not managed properly.
Tell your doctor, pharmacist, or nurse about all products you use, including prescription drugs, over-the-counter treatments, supplements, and herbal products.
This helps avoid harmful interactions and keeps your blood sugar in a safe range.
Drugs that may increase the risk of low blood sugar:
- Other diabetes drugs (such as insulin or oral tablets)
- Beta-blockers (may also hide signs of low blood sugar)
- Salicylates (like aspirin)
- MAO inhibitors (used for depression)
- ACE inhibitors (for blood pressure and heart conditions)
- Fibrates (used to lower cholesterol)
- Disopyramide (used for heart rhythm problems)
- Fluoxetine (used for depression)
- Pentamidine (used for certain infections)
- Sulfonamide antibiotics
- Anabolic steroids
- Clonidine
- Lithium salts
- Somatostatin analogs (like octreotide and lanreotide)
- Alcohol
Drugs that may raise blood sugar levels:
- Corticosteroids (used for inflammation)
- Thyroid hormones
- Diuretics (water pills)
- Estrogens or progesterone
- Atypical antipsychotics (such as olanzapine and clozapine)
- Protease inhibitors (used for HIV)
- Niacin (used for cholesterol)
- Isoniazid (used for tuberculosis)
- Glucagon
- Somatropin (growth hormone)
- Danazol
- Phenothiazines (used for mental health conditions)
- Corticotropin
- Diphenylhydantoin (phenytoin, used for seizures)
- Albuterol, epinephrine, or terbutaline (used for asthma or breathing issues)
Drugs that may cause unpredictable blood sugar effects:
- Reserpine
- Guanethidine
- Pentoxifylline
- Propoxyphene
Important note:
- Do not use Entuzity with thiazolidinediones (TZDs). This combination may increase the risk of heart failure.
Storage
Store Entuzity KwikPen in a cool, safe place to protect its quality. Keep unopened pens in the refrigerator between 2 and 8 degrees Celsius.
Do not freeze the pen, and keep it away from heat and direct sunlight. Once you start using the pen, store it at room temperature and make sure it does not get warmer than 30 degrees Celsius.
Do not put the used pen back in the fridge. Always check the expiration date before use and never use a pen that has expired or been stored in a freezer.
Dispose of the pen after 28 days, even if insulin remains, to ensure your treatment remains safe and effective.
Alternatives
If Entuzity KwikPen does not meet your needs, your doctor may suggest other types of insulin that work differently or have a longer or shorter effect.
These options can help manage blood sugar levels based on your specific health goals and daily routine.
Each insulin works in its way, so your doctor will help you choose the right one for your treatment plan.
Cost & Ordering Information
Buy Entuzity KwikPen Through Buy Canadian Insulin
Entuzity KwikPen is a prescription insulin product available through participating pharmacy partners.
Pricing may vary depending on the prescribed quantity, supplier availability, and participating pharmacy partner pricing policies. Some patients may find pricing through participating pharmacy partners that differs from certain U.S. retail pharmacy prices.
Available services may include:
- Prescription processing through participating pharmacy partners
- Multiple quantity options based on prescription authorization
- Shipping options available across eligible U.S. delivery locations
- Ordering assistance by phone, email, or live chat
- Tracking information when available through the carrier
A valid prescription from a licensed healthcare provider is required before Entuzity KwikPen can be dispensed. Prescription orders are subject to review by licensed pharmacists and applicable healthcare professionals before fulfillment.
Pharmacist consultation may be available through participating pharmacy partners for questions related to medication use, storage, administration, and prescription processing.
Shipping timelines may vary based on prescription review requirements, inventory availability, destination location, customs processing when applicable, and carrier services.
Refrigerated Shipping Information
Entuzity KwikPen is a temperature-sensitive insulin product.
Special packaging and insulated shipping materials are used to help maintain recommended storage conditions during transit.
Although every effort is made to protect temperature-sensitive medications during shipment, temporary temperature fluctuations may occur during transportation.
Upon delivery:
- Inspect the package promptly
- Follow the storage instructions provided with the medication
- Store unopened pens in a refrigerator between 2°C and 8°C (36°F to 46°F)
- Do not freeze the medication
- Do not use insulin that has been frozen
Patients with questions regarding product storage after delivery should contact their pharmacist or healthcare provider.
Prescription Discounts and Coupons
Eligible first-time customers may use coupon code FIRST10 during checkout for qualifying orders, subject to current promotional terms and conditions.
Ordering Information
Have a Prescription?
Patients may explore available prescription options through participating pharmacy partners.
Available ordering features may include:
- Online ordering availability
- Phone ordering assistance
- Quantity options based on prescription authorization
- Shipping options with tracking when available
- Customer support assistance through phone, email, or live chat
Customer Support & Business Information
For questions regarding prescription processing, product availability, shipping timelines, or account support, contact Buy Canadian Insulin customer support:
Phone: 1-888-525-1815
Fax: 1-888-234-1275
Email: info@buycanadianinsulin.com
Customer Support Hours
Monday-Friday: 7 am – 10 pm CST
Saturday & Sunday: 9 am – 5 pm CST
Business Address
Buy Canadian Insulin
1026 Manitoba Avenue, Suite 1001
Selkirk, MB R1A 4M2
Canada
About Buy Canadian Insulin Services
Buy Canadian Insulin works with participating pharmacy partners to help patients access prescription medications and related healthcare products.
Product availability, pricing, and shipping timelines may vary depending on supplier inventory, participating pharmacy partner availability, and destination location.
Some prescription orders may be dispensed by licensed pharmacy partners located in Canada or other international fulfillment locations depending on product availability and applicable pharmacy regulations.
Orders are packaged and shipped according to pharmacy handling procedures and applicable storage requirements.
Have a prescription?
Order Entuzity KwikPen online today and enjoy a host of benefits, including:
Frequently Asked Questions
Disclaimer
Buy Canadian Insulin provides educational information about medications and health conditions for informational purposes only. This content is not intended to replace professional medical advice, diagnosis, or treatment. Prescription medications require valid prescription review and processing through participating pharmacy partners. Product availability, pricing, and shipping timelines may vary. Consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
