Fragmin (Dalteparin)
from$84.95
$724
Fragmin Dalteparin Sodium
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Select product strength & quantity:
Select product strength & quantity:
Select product strength & quantity:
Select product strength & quantity:
Select product strength & quantity:
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Cold-Chain Shipping Notice

This medication requires specialized cold-chain packaging to help maintain its quality and integrity during transit. Each shipment includes a temperature indicator to monitor storage conditions throughout the shipping process.

Do NOT use this medication if the attached temperature indicator shows that it was exposed to temperatures below 2°C (36°F) or above 8°C (46°F). If the temperature indicator shows that the acceptable temperature range has been exceeded, or if you have any concerns about the condition of your shipment upon arrival, do not use the medication and contact our pharmacy immediately for further instructions and assistance.

Please inspect your shipment and the temperature indicator as soon as it is delivered.

What is Fragmin (dalteparin)?

Fragmin, also known as dalteparin, is a low molecular weight heparin used prophylactically and in the treatment of deep vein thrombosis (DVT) and certain ischemic complications of unstable angina and myocardial infarction. Fragmin is also used for the extended treatment of symptomatic venous thromboembolism (VTE) in cancer patients.

How does Fragmin work?

Fragmin (dalteparin) is a low molecular weight heparin (LMWH) that exerts anticoagulant effects by enhancing the activity of antithrombin III (AT-III), which inhibits activated clotting factors, primarily factor Xa and to a lesser extent factor IIa (thrombin).

Dosage and How to Use

Fragmin is available in the following strengths and dosage forms:

  • Single-dose prefilled syringe
    • 2,500 IU / 0.2 mL
    • 5,000 IU / 0.2 mL
    • 7,500 IU / 0.3 mL
  • Single-dose graduated syringe
    • 10,000 IU / 1 mL
  • Single-dose prefilled syringe
    • 12,500 IU / 0.5 mL
    • 15,000 IU / 0.6 mL
    • 18,000 IU / 0.72 mL
  • Multiple-dose vial
    • 95,000 IU / 3.8 mL (25,000 IU / mL)

The dosing for Fragmin varies greatly and depends on the indication that it is being used for. Make sure to take the medication exactly as directed by your doctor, as dosing is highly individualized based on weight, renal function, and indication.

For DVT prophylaxis in medical patients, the dose is 5,000 IU subcutaneous injection once daily. For most other indications, the dose of Fragmin is determined using a patient’s weight and must be given at specific timeframes around surgery.

Fragmin is given as a subcutaneous injection and cannot be given intramuscularly.

Subcutaneous injection

  • Patients should lie or sit down, and Fragmin is given as a deep subcutaneous injection.
  • Acceptable injection sites include a U-shape around the navel, the upper outer side of the thigh, or the buttocks.
  • When injecting near the navel or in the thigh, a thumb and forefinger must be used to lift a skin fold to insert the entire needle at a 45 to 90-degree angle.
  • The injection site should change daily.

For detailed instructions on injection technique, please consult your pharmacist or doctor.

Storage

Store at 20° to 25°C (68° to 77°F). Temperature excursions are permitted between 15°C to 30°C (59°F to 86°F). Multiple-dose vials can be stored at room temperature for up to 2 weeks after the first puncture.

Overdosage

If there has been an overdose of Fragmin, seek medical attention due to the risk of hemorrhagic complications. Protamine sulfate is an antidote for Fragmin and other low molecular weight heparins that must be given through intravenous infusion under medical care. It is important to know the amount of Fragmin and when it was injected because that will help medical providers determine how much protamine sulfate will be needed.

Side Effects

The common side effects of Fragmin can include:

  • Redness, pain, or irritation around the injection site

Serious side effects are possible with Fragmin. Contact your doctor immediately if you experience one of the following symptoms of a serious side effect.

  • Bleeding problems such as vomiting or coughing up blood, blood in the urine, abnormal vaginal bleeding, red or tarry stools, unusual bruising
  • Back pain
  • Paralysis
  • Leaking of urine or stool
  • Severe dizziness, confusion, or passing out
  • Severe headache
  • Burning or numbness feeling
  • Muscle weakness
  • Signs of a severe allergic reaction, such as hives, itching, red skin, trouble breathing, or swelling of the face or lips

This is not a comprehensive list of all the possible side effects of Fragmin. Reach out to your pharmacist or doctor for more information.

Warnings & Precautions

Boxed Warning

Risk of Hemorrhage, including Spinal/Epidural Hematomas

  • Spinal or epidural hemorrhage and subsequent hematomas can occur with the associated use of low molecular weight heparins or heparinoids and neuraxial (spinal/epidural) anesthesia or spinal puncture.
  • Use Fragmin with extreme caution in patients with an increased risk of hemorrhage, such as those with severe uncontrolled hypertension, bacterial endocarditis, congenital or acquired bleeding disorders, active ulceration, angiodysplastic gastrointestinal disease, hemorrhagic stroke, or shortly after brain, spinal or ophthalmological surgery.

Other Warnings & Precautions

Thrombocytopenia

  • Monitor platelet counts periodically to detect heparin-induced thrombocytopenia (HIT), which can occur with the administration of LMWHs such as Fragmin. The incidence of this complication is currently unknown. In clinical practice, cases of thrombocytopenia with thrombosis, amputation, and death have been observed.

Risk of Serious Adverse Reactions in Neonates and Infants due to Benzyl Alcohol Preservative

  • Use preservative-free Fragmin in neonates and infants. Serious and fatal adverse reactions, including gasping syndrome, can occur in neonates and low birth-weight infants treated with medications containing benzyl alcohol. Benzyl alcohol is used in multiple-dose vials of Fragmin.

Laboratory Tests

  • Periodic routine complete blood counts, including platelet count, blood chemistry, and stool occult blood tests are recommended during treatment with Fragmin.

Drug Interactions and Other Interactions

Using Fragmin in patients receiving oral anticoagulants, platelet inhibitors, and thrombolytic agents may increase the risk of bleeding.

Contraindications

Fragmin is contraindicated in patients with any of the following:

  • Active major bleeding
  • History of heparin-induced thrombocytopenia or heparin-induced thrombocytopenia with thrombosis
  • Prior hypersensitivity to dalteparin sodium (e.g., pruritis, rash, anaphylactic reactions)
  • Patients undergoing Epidural/Neuraxial anesthesia, do not administer Fragmin for the following:
    • As a treatment for unstable angina and non-Q-wave MI
    • For prolonged VTE prophylaxis
  • Patients with prior hypersensitivity to heparin or pork products

Cost & Ordering Information

Buy Fragmin Through Buy Canadian Insulin

Buy Canadian Insulin helps patients access Fragmin through participating pharmacy partners.

Pricing may vary depending on product strength, quantity selected, supplier availability, and participating pharmacy partner pricing policies.

Some patients may find pricing through participating pharmacy partners that differs from certain U.S. retail pharmacy prices.

Available services may include:

  • Pricing options based on quantity selected
  • Prescription processing through participating pharmacy partners
  • Shipping options available across eligible U.S. delivery locations
  • Ordering support through phone, email, or live chat
  • Multiple quantity options depending on prescription authorization and supplier availability

A valid prescription is required for Fragmin.

Prescription medications require review and approval by a licensed healthcare professional and pharmacist before dispensing, where applicable.

Shipping timelines may vary depending on prescription review requirements, inventory availability, destination location, and carrier services.

Prescription Medications Discounts and Coupons

Eligible first-time customers may use coupon code FIRST10 during checkout for qualifying orders, subject to current promotional terms and conditions.

Ordering Information

Patients may explore available Fragmin prescription options through participating pharmacy partners.

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Product availability, pricing, and shipping timelines may vary depending on supplier inventory, participating pharmacy partner availability, and destination location.

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Frequently Asked Questions

Fragmin is used to prevent and treat certain types of blood clots, often in the legs or other blood clots that can lead to heart attacks.

Fragmin is a low molecular weight heparin (LMWH) that works by inhibiting certain clotting factors (factor Xa and IIa) to stop blood clots from forming.

You should take Fragmin as a subcutaneous injection. The correct dose will be determined by your doctor and can change depending on what the medication is being used for. Make sure to take Fragmin exactly as directed by your doctor. Subcutaneous injection
  • Patients should be lying or sitting down, and Fragmin is given as a deep subcutaneous injection.
  • Acceptable injection sites include a U-shape around the navel, the upper outer side of the thigh, or the buttock.
  • When injecting near the navel or in the thigh, a thumb and forefinger must be used to lift a skin fold to insert the entire needle at a 45 to 90-degree angle.
  • The injection site should change daily.
For detailed instructions on injection technique, please consult your pharmacist or doctor.

Patients who have any of the following should not take Fragmin:
  • Active major bleeding
  • History of heparin-induced thrombocytopenia or heparin-induced thrombocytopenia with thrombosis
  • Prior hypersensitivity to dalteparin sodium (e.g., pruritis, rash, anaphylactic reactions)
  • Patients undergoing Epidural/Neuraxial anesthesia, do not administer Fragmin for the following:
    • As a treatment for unstable angina and non-Q-wave MI
    • For prolonged VTE prophylaxis
  • Patients with prior hypersensitivity to heparin or pork products

The common side effects of Fragmin are discomfort or itching around the injection site. This is not the only side effect that may occur. Reach out to your doctor or pharmacist for more information.

Serious side effects with Fragmin are possible. Reach out to your doctor immediately if you experience any of the following symptoms of a serious side effect.
  • Signs of bleeding, such as coughing or throwing up blood, dark or tarry stools, abnormal vaginal bleeding, or unusual bruising
  • Signs of an allergic reaction like rash, hives, red or swollen skin, trouble breathing, or swelling of the mouth and lips
  • Dizziness or passing out
  • Confusion
  • Severe headache
  • Muscle weakness
  • Abnormal burning feeling, numbness, or weakness

Store Fragmin at 20° to 25°C (68° to 77°F). Temperature excursions are permitted between 15°C to 30°C (59°F to 86°F). Multiple-dose vials can be stored at room temperature for up to 2 weeks after the first puncture.

Take the missed dose as soon as you remember. If it is close to your next dose, skip the missed dose and resume your regular dosing schedule. Never take 2 doses at the same time.

Fragmin is not known to interact with any foods, so there is no need to change your diet when starting the medication.

Seek medical attention due to the risk of bleeding complications. There is an antidote for Fragmin that must be given under medical care. If possible, keep track of the amount of Fragmin that was injected and at what time it was injected because that will help medical providers determine how much of the antidote will be needed.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are receiving a dalteparin injection.

Disclaimer

Buy Canadian Insulin provides educational information about medications and health conditions for informational purposes only. This content is not intended to replace professional medical advice, diagnosis, or treatment. Prescription medications require valid prescription review and processing through participating pharmacy partners. Product availability, pricing, and shipping timelines may vary. Consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.

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Kenneth Fill, PharmD, MBA

Kenneth Fill, PharmD, MBA, is a clinical pharmacist specialist and medical writer with a strong background in ambulatory care, pharmacogenomics, and medical content development. Based in the state of Michigan, he provides expert guidance on chronic disease state management. Kenneth completed his PharmD and MBA at the University of Toledo and pursued post-graduate residency training in ambulatory care and community-based pharmacy. His diverse background also includes academic detailing, clinical education, and interdisciplinary collaboration to enhance patient outcomes.