Glumetza 500mg
Metformin Hydrochloride
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Prescription Required.

Product of Canada.

Shipped from Canada.

Prescription Required.Product of Canada.Shipped from Canada.


Glumetza is a biguanide that contains metformin hydrochloride. It is a prescription medication used in addition to diet and exercise to improve glucose control in adults with type II diabetes mellitus (T2DM). Controlling hyperglycemia prevents downstream complications such as kidney damage, loss of limbs, blindness, heart attack, stroke, or nerve problems. It is important that diabetes remains controlled to lessen the chance of related complications. Glumetza is not recommended for the treatment of type I diabetes mellitus (T1DM) or for patients with diabetic ketoacidosis.


Glumetza is an antidiabetic agent that works by decreasing basal and postprandial plasma glucose. Metformin lessens absorption of glucose in the intestine, lowers hepatic production of glucose, and increases insulin sensitivity by elevating peripheral glucose utilization. Metformin’s exact mechanism is not well understood, but a few methods have been postulated. These include inhibiting mitochondrial complex I activity, stimulating AMP-activated protein kinase (AMPK), inhibition of glucagon-induced increases in cyclic adenosine monophosphate (cAMP), decreasing activation of protein kinase A (PKA), and affecting gut microbiota. With Glumetza, insulin secretion does not change, however, all-day plasma insulin response and fasting insulin levels can decrease.