Humalog Vial 100 Units / mL
Humalog Vial
Insulin Lispro
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What is Humalog® U-100 Insulin?

Humalog (insulin lispro) is fast-acting insulin used to treat type 1 and type 2 diabetes patients manage their blood sugar levels.

Insulin lispro is closely related to human insulin which is the natural hormone produced by the pancreas.

This man-made insulin is both safe and effective in treating both adults and children over the age of 3. It is unknown whether Humalog is safe and effective for children with type 1 diabetes under the age of 3 or children with type 2 diabetes.

Humalog is a substitute for human insulin and used to control glucose levels. Since the molecules in this insulin have been modified, it works faster than normal human insulin.

It increases the rate at which the body converts glucose to glycogen which is stored in the muscle to later be used as energy.

Each vial contains 1000 units (10 millilitres). Humalog 100 units/ml solution for injection in vial comes in a pack of 1 vial, 2 vials or a multipack of 5 x 1 vial.

The other ingredients are glycerol, m-cresol, zinc oxide, dibasic sodium phosphate 7 H2O and water for injection. Hydrochloric acid or sodium hydroxide may have been used to adjust the acidity.

How to Use Humalog Insulin?

Humalog comes already dissolved in water so you don’t need to mix it however it should only be used if it appears clear, colorless with no particles, like water.

Humalog works very quickly and can last for shorter periods than soluble insulin. Typically this insulin is used 15 minutes within starting your meal.

Your doctor may recommend taking Humalog insulin vials in combination with longer-lasting insulin.

For application:

1. First wash your hands
2. Clean the skin and rubber stopper on vial as instructed before injection.
3. Use a clear, sterile syringe to pierce the rubber stopper to draw the recommended dosage amount.
4. Inject insulin under the skin within 1cm from the last injection.
5. After injection leave the need in the skin for 5 seconds to ensure you have taken the full dose

Rotate injection sites as instructed. Medication can be used in the thigh, upper arm, buttock or abdomen.

Do not rub the area after injection.

Do not share insulin with other people as this can spread blood-borne pathogens.

Do not inject directly into a vein.

Do not mix Humalog with other insulin manufacturers or with animal insulin.

Do not administer Humalog insulin intravenously. This should only be done by a doctor.


Side Effects with Humalog Insulin

Similar to any medication, Humalog insulin may cause side effects however not everyone experiences them. Humalog insulin side effects may include:

  • Sweating
  • Increased heart beat
  • Difficulty breathing/wheezing
  • Drop in blood pressure
  • Rash all over the body

Some experienced localized allergy at the site of injection which may include swelling, itching or redness. Typically it clears up within a few days to weeks. Notify your doctor if you experience allergic reactions.

Amyloid (lumps under the skin) may be caused at injection sites due to a build up of protein. Repetitive injecting into a single site may also cause lipohypertrophy (skin thickening) or lipoatrophy (shrinking of fatty tissue). To avoid these skin issues from happening you should rotate injection sites.

Oedema (fluid retention;swelling of ankles and arms) has been reported at the start of treatment or during changes of blood glucose control.

If you are feeling ill after taking Humalog insulin you made need to adjust your dosage levels. Even if your eating habits have changed, you still require insulin. Test your blood & urine and consult a doctor.

Also speak to your doctor or pharmacist if you experience any side effects including those not listed above.

Common problems with diabetes:

Hypoglycemia or low blood sugar means there is not a sufficient amount of sugar in the blood. This can be caused if:

  • you take too much insulin
  • you delay or miss meals or change your diet
  • you exercise too much before/after meals
  • you have an illness or infection
  • you have trouble with your heart, liver or kidneys
  • alcohol may affect blood sugar levels

Symptoms of low blood sugar usually are immediate and include:

  • tiredness
  • shakiness or nervousness
  • headaches
  • cold sweats
  • increased heartbeat
  • feeling sick

Hyperglycemia or too much sugar in the blood can lead to ketoacidosis. It happens when your body does not have enough insulin and can be brought about by:

  • not taking your prescription insulin like Humalog
  • taking less insulin that advised
  • fever, emotional stress or infection
  • eat more than your recommended diet allows

Symptoms may include:

  • flushed face
  • increased thirst
  • no appetite
  • feeling sick
  • fruit smell on breath
  • rapid pulse
  • heavy breathing

If you are feeling any of these symptoms you should contact your doctor.

Warnings and precautions

Humalog may cause a drop in blood sugar levels (hypoglycemia)

Always check your insulin labels when receiving them from your pharmacy or before use so it is not potentially confused for other medications you are taking.

Some patients have reported experiencing hypoglycemia when they switched to human insulin from animal insulin.

Your insulin dosage my need to change if you are taking any of the following medications:

  • contraceptive pills
  • oral hypoglycemics
  • steroids
  • thyroid medication
  • sulpha antibiotics
  • acetyl salicyclic acid
  • antidepressants
  • beta blockers

Speak with your doctor if you are taking any medications or supplements not listed above.

If you are pregnant or breast-feeding then you may require adjusting your insulin dosages. Typically dosage amounts may drop during the first trimester of pregnancy and increase during the second and third. Consult your doctor about recommended dosage.

It’s possible that your ability to concentrate my be affected due to hypoglycemia. For this reason you should not drive or operate machinery while using this insulin. Symptoms may differ for each patient.

Some may experience heart failure, shortness of breath, increased weight gain and localized swelling (oedema).

Rotate injection sites to avoid causing skin damage such as lumps. Humalog will not work well if injected into a lumpy area.

Your doctor may recommend monitoring your blood sugar levels closely and adjust your insulin dosage and other antidiabetic medications.

Carry glucose tablets, candy or sugary drinks just in case you experience low blood sugar (mild hypoglycemia).

Do NOT use Humalog if..

  • You are experiencing hypoglycemia (low blood sugar)
  • If you have an allergy to insulin lispro or other ingredients in this medication

Humalog Insulin Storage

  • Before first use, Humalog insulin vials should be stored in a refrigerator with temperatures between 2°C – 8°C.
  • When in use you may keep it refrigerated (between 2°C – 8°C) or at room temperature.
  • Never store this medication in a freezer or near heat or sunlight.
  • Keep insulin out of reach from children.
  • Discard medication after 28 days.
  • Do not dispose via wastewater or household water. Speak to your pharmacist about how to properly dispose of medication. Proper insulin disposal helps protect the environment.

Additional Information

Notify your doctor if you feel that symptoms have not improved after starting treatment.

Frequently Asked Questions

Humalog is the brand name for insulin lispro which is commonly prescribed for patients with type 1 & type 2 diabetes to manage blood sugar levels.

Yes, Humalog (insulin lispro) is an insulin used to treat diabetes types 1 and 2. It is very closely related to human insulin which is a natural hormone produced by the pancreas.

Humalog dosage varies from person-to-person and is based on a number of factors such as weight and other medications currently being taken. Initial dosage should be determined in collaboration with your doctor.

According to the American Diabetes Association, when starting a rapid-acting insulin such as Humalog, patients should take 4 units or 10% of their long-acting insulin dose. It is recommended to take your dose along with your largest meal of the day.

You and your doctor can work together to create a schedule that makes sense for you. Humalog is typically taken at mealtime. It is best to take Humalog either 15 minutes before or immediately after meal times. It is best not to skip meals or postpone eating after taking Humalog. Typically Humalog is taken twice a day, at breakfast and at dinner.

Always rotate your injection sites with every dose to avoid developing skin complications such as lipodystrophy or amyloidosis.

No, Humalog comes already dissolved in water and it does not need to be mixed. Only use Humalog if it appears clear and colorless like water. There should be no visible floating particles.

Does Humalog have any side effects?

Low blood sugar is the most common side effect of insulin lispro. Weight gain, sweating, rapid heartbeat, shaking, dizziness, nausea, and drowsiness are all symptoms of low blood sugar. If you experience any of these symptoms, contact your doctor.


What do I do if I miss a dose?

It is important to follow a strict regimen and never miss a dose of Humalog. Make a plan with your doctor ahead of time to prepare in case you do miss a dose.

Do I need to take Humalog with food?

Yes, Humalog is designed to be taken at mealtime. Humalog works best when taken 15 minutes before or immediately after a meal.

Can I take Humalog at bedtime?

No, Humalog should always be taken at mealtime to properly regulate your blood sugar throughout the day.

Should I take Humalog before or after I eat?

Humalog can be taken up to 15 minutes before eating a meal or immediately after eating a meal.

How often should Humalog be taken?

Typically Humalog is taken twice a day, at breakfast and at dinner.

What are the ingredients in Humalog?

The main ingredient in Humalog is insulin lispro. Every milliliter of Humalog also contains 16 mg glycerin, 1.88 mg dibasic sodium phosphate, 3.15 mg Metacresol, zinc oxide, phenol, and water.

What type of insulin is Humalog?

Humalog is a fast-acting insulin.It starts working faster for shorter periods of time than human insulin.

How long does Humalog last?
Humalog is fast-acting and its effects begin to work approximately 15 minutes following injection. Humalog continues to work for about two to four hours after injection.

Who can use Humalog?

Humalog is an insulin lispro injection for patients with Diabetes. It is used to manage blood sugar levels.

Is Humalog fast-acting or long lasting?

Humalog is a fast-acting insulin. It works for shorter amounts of time than human insulin.

Can I drink alcohol while taking Humalog?

It is best to limit one’s alcohol intake while using insulin. Alcohol increases one’s risk for low blood sugar.

Can I smoke cigarettes while taking Humalog?

If you use tobacco products like cigarettes while taking Humalog you may need to check your blood sugar more often. Nicotine, an active ingredient in tobacco,  has the ability to increase blood sugar.

Can I reuse my Humalog needle?

No, Humalog needles are disposable and are not meant for reuse. Reusing needles increases your risk of infection.

What is the difference between Lantus and Humalog?

Lantus (insulin glargine) is a long-acting insulin that provides all-day blood sugar control. Lantus can cause low blood sugar. Humalog (insulin lispro) is a fast-acting insulin. It works by controlling blood sugar during meal time.

What dosage of Humalog should I take?

The amount of Humalog to take varies from person to person. Blood sugar readings are necessary for any patients using insulin. Usually, the amount of insulin a patient takes per day is between .5 and 1 unit per kg of body weight.

How is Humalog stored?

Unopened Humalog must be stored in a refrigerator. Humalog should never be frozen. After opening, Humalog should be stored at room temperature. If unopened and not refrigerated, Humalog should be discarded after 28 days.

Opened Humalog pens should be stored at room temperature, outside of the refrigerator. They should be kept away from heat and direct light.


What do I get when I order Humalog?

Humalog can be purchased in the form of 100u/ml vials.

Can you mix Humalog with Lantus?

You should not mix Humalog and Lantus.

Can I take Humalog and Novolog at the same time?

Compared to Novolog, Humalog use has been correlated with lower blood sugar levels during the first hour after a normal meal.

What if I don’t have enough insulin left in my pen?

If your pen doesn’t contain enough insulin to complete your full dose, you must calculate how much you’ll need from a new pen by subtracting the amount that’s in your current pen from the amount you normally take.

How much does Humalog cost in Canada?

Humalog can cost patients over $1000 in the United States. Using this website, you can purchase Humalog at a fraction of the cost. You can also call our toll free number at 1-888-525-1815 to purchase discounted Humalog from a legitimate Canadian pharmacy.


Can I buy Humalog online?

If you have a prescription for Humalog, you can buy it legitimately online.

Buying medication online can be deceptively cheap and easy because there are many sites which are operating illegally. Please avoid these at all costs as their products could be dangerous to consume

When you purchase Humalog online through our site you are purchasing from a legitimate, licensed pharmacy. Contact us today!

Low blood sugar is the most common side effect of insulin lispro. Weight gain, sweating, rapid heartbeat, shaking, dizziness, nausea, and drowsiness are all symptoms of low blood sugar. If you experience any of these symptoms, contact your doctor. See section on Humalog side effects above.

It is important to follow a strict regimen and never miss a dose of Humalog. Make a plan with your doctor ahead of time to prepare in case you do miss a dose and/or complications arise.