Humulin N Vials
Humulin N Vial
Insulin Isophane (Nph)
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Prescription Required.

Product of Canada.

Express Ships from Canada.

Prescription Required.
Product of Canada.
Express Ships from Canada.

What is Humulin N?

Humalin N (insulin isophane) is a man-made form of insulin that helps adults and children with type 1 and type 2 diabetes better manage blood sugar levels.

Insulin isophane is an intermediate-acting insulin that begins working within 2-4 hours after administration, peaks in 4-12 hours and continues to work up to 12-18 hours.

Humulin N is available in both Humulin N U-100 vials and as the prefilled Humilin N KwikPen.

Humulin N is injected underneath the skin (subcutaneously).

Before taking Humulin, be sure to tell your doctor if:

  • You have had heart, liver or kidney disease
  • Have low levels of potassium (hypokalemia)
  • Are pregnant or breastfeeding
  • Taking prescription or over-the-counter medications or supplements

If you are pregnant, it’s important to control your diabetes as having high blood sugar can cause complications for both you and the baby.

Humulin N should be part of a treatment program along with a proper diet, exercises, weight control and blood sugar testing. Follow your doctors instructions carefully.


Follow directions according to the prescription label and medical direction. Familiarize yourself with instruction sheets and medical guides. Consult your doctor if you have any questions.

It is important to use a syringe marked for U-100 insulin preparations for the Humulin N U-100 vials.

Humulin N is injected under the skin. Your doctor or nurse should instruct you how to properly administer the medication yourself.

When injecting insulin, you should rotate injection sites. Do not inject in the same place twice in a row.

Do not inject into skin that is tender, damaged, bruised, scaly, pitted, thickened or has a scar or lump.

Humulin N should appear cloudy after mixing. Do not use if the mixture appears clear or has particles inside. If this is the case, contact your pharmacist for new medication.

Never share syringes or injection pens with others as this can lead to spreading infections and diseases from one person to another.

Storing Humulin N

Keep this medication in its original packaging away from heat or light.

Unless you are ready to inject, do not draw insulin from the vial.

Do not store near cooling element or freeze. If insulin has been previously frozen, throw it out.

Store insulin at room temperature or in a refrigerator and use until expiration date. Do not refrigerate an injection pen that is in use.

Throw away any medication that is not used past the expiry date.

Used needles and syringes should go into a puncture-proof “sharps” container. Your pharmacist should instruct you on how to properly dispose of insulin pens and needles.

Wear or carry medical identification that lets others know you are diabetic.

Side Effects

This is not a complete list of side effects related to Humulin N but include:

  • Low blood sugar (hypoglycemia)
  • Weight gain
  • Swelling of hands and feet
  • Mild skin rash and itching
  • Hollowing of skin or thickening at site of injection

Low blood sugar (hypoglycemia) is the most common side effect with insulin medication such as Humulin N. Symptoms of hypoglycemia include:

  • headache
  • sweating
  • hunger
  • pale skin
  • irritability
  • dizziness
  • trouble concentrating
  • feeling shaky
  • seizure (convulsions)
  • trouble speaking
  • loss of consciousness
  • muscle weakness
  • numbness or tingling in mouth
  • blurred vision
  • drowsiness

To avoid experiencing these symptoms, carry a piece of non-diabetic candy, glucose tablet or sugary drink (not diet) in case you blood sugar levels drop.

If you experience any of the following symptoms, seek medical attention immediately:

  • allergic reaction over entire body
  • trouble breathing
  • feeling you might pass out
  • swelling of tongue and throat
  • low potassium (hyperkalemia)
  • swelling in hands and feet
  • fluid retention

Warnings & Precautions

If you hare having an episode of low blood sugar you should suspend use of Humulin N and consult with your doctor.

Do not inject directly into a vein or muscle.

Do not use if the insulin substance remains at the bottom or contains clumps at the bottom of the vial after mixing.

Do not share pens and needles with others even if the needle has been changed. These should be single-patient only and sharing pens and needles can lead to spreading of infection and disease.

If you overdose on your insulin contact medical attention immediately as this can lead to life-threatening hypoglycemia.

Get your Humulin N prescription refilled before you run out of medicine completely.

Do not give Humulin to a child unless under the direction of a doctor.

Humulin N should not be administered using an insulin pump or mixed with other insulin.

Your doctor can prescribe a glucagon emergency kit in case you experience severe hypoglycemia which may affect your eating habits. Instruct your family and friends how to inject the emergency injection kit in case of emergency.

Be aware of sings of high blood sugar (hyperglycemia) that can cause increased thirst and urination.

Speak to your doctor about adjusting your medication schedule as blood sugar levels can be affected by surgery, illness, exercise, stress, skipping meals and alcohol.

If you can, avoid drinking as it can lower blood sugar levels and may interfere with your diabetes treatment.

If you miss a dose and it is almost time for your next dose, do not double up. Continue with your regular dosage.

Frequently Asked Questions

Humulin N is available in two different vial sizes: 3 mL and 10 mL. Both of these vial sizes contain the same strength of insulin (100 units/mL).

Since the Humulin N vials do not have pre-measured doses, the amount of Humulin N that a patient will need to take will be determined by their physician. Most patients begin with lower doses until they become more familiar with how the Humulin N works with their body and affects their blood glucose levels. Other factors will play a part in determining how much Humulin N a patient may need to use, include additional health conditions, the amount of exercise a patient engages in, and their usual dietary habits.

No. Humulin N is able to be used by patients with type 1 diabetes as well as those who have type 2 diabetes. However, the dosage for these two conditions typically varies, and patients using Humulin N for the two different conditions may have different experiences from each other.

Any changes to the amount of Humulin N a patient uses each day should be discussed with their prescribing physician. Patients should not modify their Humulin N dosage without first consulting with their doctor. Changing one’s dosage on their own may result in potentially serious health risks associated with receiving too little or too much insulin. Some of the factors that may warrant a change in a patient’s dosage include changes in weight, changes in diet, changes in exercise habits, changes regarding other medications they may be taking, problems with their liver, or problems with their kidneys.

Humulin N should be injected into the fatty tissue just underneath the skin. The most commonly recommended areas to use as injection sites are the backsides of the upper arms, the stomach, or the tops or outside areas of the thighs. The injection site should be rotated each time the medication is used to avoid skin damage, lumps, irritation, and other issues that occur when an injection site is overused too frequently. Additionally, patients should be sure to use a new needle each time they need to inject their Humulin N to avoid infection.

If a patient has missed a dose of Humulin N, they should consult with their pharmacist or prescribing physician regarding how to handle the situation. Sometimes, a patient may be advised to go ahead and inject their missed dose of Humulin N. If the patient’s next upcoming dose is approaching soon, though, they may be recommended to simply disregard the missed dose and proceed with injecting their next dose at the regularly scheduled time.

A vial of Humulin N may be stored in the refrigerator for 31 days before it needs to be discarded. After this entire one-month period has passed, the medication should be disposed of, regardless of whether any remains in the vial.

The number of vials of Humulin N that a patient may need each month will vary based on a variety of factors. However, the majority of patients with diabetes will require two to three vials of insulin each month. In some cases, a patient may require additional vials compared to most other patients.

It is safe to inject Humulin N if it is still cold from being refrigerated. However, injecting cold insulin has often been reported to be highly uncomfortable and even painful for patients who have done so. Therefore, it is often recommended that you allow your Humulin N to come to room temperature before using it.

If your Humulin N has been left out overnight, the medication should not be negatively impacted and should still be safe to use and as effective as usual. If your Humulin N has been left in excessively hot temperatures, it may become less effective. Insulin should never be frozen. Although leaving your vial of Humulin N out overnight may be acceptable, please contact your pharmacist or prescribing physician if your vial has been exposed to extreme temperatures, as the medication may be significantly impacted.

Humulin N (isophane insulin human) is considered an intermediate-acting, regular insulin. When using Humulin N, it releases into the body more slowly than some of the short-acting insulin options available, allowing patients to better manage their blood glucose levels for an average of 12 to 18 hours after injection.

Yes. Humulin N has been shown to be well-suited for use by pregnant patients that need to manage the short-term diabetic condition known as gestational diabetes. Pregnant patients that develop gestational diabetes should consult with their doctor about the safety and efficacy of Humulin N for managing their condition for the rest of their pregnancy.

Humulin N has been approved for use in children. It has been shown to be safe and effective at managing both type 1 as well as type 2 diabetes in this age group.

Before beginning treatment with Humulin N, patients should be sure to discuss their medical history and all current medications with their physician before use. Those who have current comorbid conditions or are actively taking additional medications, especially additional diabetic medications (e.g., Actos or Avandia), may require an adjustment to their recommended daily dosage of Humulin N or may require a different type of insulin for managing their diabetes. There is also an increased risk of health concerns for those who have kidney issues, liver issues, or heart failure.

When getting ready to use your Humulin N, you will need to prepare the medication within the vial first. Be sure to use a new needle each time you use the medication. To ensure that your Humulin N is properly mixed and distributed within the vial, you should first roll the vial gently between your palms about ten times to carefully mix the medication, resolving any settling that may have occurred. Flip the vial upside down about ten times as well, further mixing the medication, but do not shake your vial vigorously. Your Humulin N is well-mixed and ready for injection when it appears cloudy and white without any visible particles or lumps.

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