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Humulin R Vial Insulin Injection Human Biosynthetic
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Cold-Chain Shipping Notice

This medication requires specialized cold-chain packaging to help maintain its quality and integrity during transit. Each shipment includes a temperature indicator to monitor storage conditions throughout the shipping process.

Do NOT use this medication if the attached temperature indicator shows that it was exposed to temperatures below 2°C (36°F) or above 8°C (46°F). If the temperature indicator shows that the acceptable temperature range has been exceeded, or if you have any concerns about the condition of your shipment upon arrival, do not use the medication and contact our pharmacy immediately for further instructions and assistance.

Please inspect your shipment and the temperature indicator as soon as it is delivered.

What is Humulin® R U-100?

Humulin R is a polypeptide hormone that is structurally similar to human insulin produced in the body. It effectively helps manage blood sugar levels for both adults and children with type 1 and type 2 diabetes.

Insulin is a hormone made by the pancreas that helps regulate blood sugar levels. Insulin is necessary for managing glucose (sugar) in the blood.

People with type 1 diabetes produce little to no insulin, while some with type 2 diabetes may not produce enough or use it effectively, requiring insulin therapy.

Humulin R U-100 is injected under the skin (subcutaneously). Insulin should not be injected into a vein or muscle. Make sure you are using a syringe marked U-100.

This short-acting insulin starts working within 30 minutes, peaks in 2-3 hours, and lasts about 5 to 8 hours.

Through the use of insulin, patients can effectively break down carbohydrates, fats, and proteins. With proper carbohydrate metabolism, patients can avoid the production of ketone bodies in the liver and other complications associated with diabetes.

Humulin R (insulin human recombinant) U-100 is a clear, sterile, and colorless solution that contains human insulin at 100 units/mL, endogenous zinc, metacresol, and water. Hydrochloric acid and/or sodium hydroxide may be added to adjust the pH levels during the manufacturing of this medication.

Humulin R Usage Instructions

You should not take this medication if you are allergic to insulin or are experiencing symptoms of hypoglycemia.

Tell your doctor if you have any pre-existing liver, kidney, or heart conditions.

Notify your doctor if you are taking any medications such as rosiglitazone or pioglitazone. Taking certain medications can increase the risk of heart problems.

Tell your doctor if you are currently breastfeeding or pregnant.

If you are pregnant, follow your doctor’s instructions carefully. It’s important to manage diabetes during pregnancy, and high blood sugar can affect both the mother and baby.

How is Humulin R insulin used?

Your doctor or nurse should instruct you on how to properly inject insulin, which should not be injected into a vein or muscle. Use a different injection site every time to avoid damaging skin.

Do not inject into skin that is damaged, bruised, pitted, scaly, thickened, has scarring or lumps.

Only prepare your Humulin R injection when you are ready to administer. Do not use Humulin R insulin if it appears cloudy or has particles. If your medication seems compromised, contact your pharmacist for a new one.

You should eat a meal within 30 minutes of administering Humulin R to prevent hypoglycemia.

If your doctor prescribes a glucagon injection kit in case of severe hypoglycemia, be sure to instruct family or friends on how to use it.

Storing Humulin R

Keep away from heat or light.

Do not freeze insulin or store it near a cooling element. Throw away if previously frozen.

Keep insulin refrigerated and use until expiration date, or store at room temperature if in use.

Throw away expired insulin. Any needles or syringes should be placed in a puncture-proof “sharps” container. Speak to your pharmacist about properly disposing of needles and medication.

Keep medication away from children or pets.

Humulin R Side Effects

Symptoms associated with using insulin can differ depending on a patient’s health, treatment, and condition.

Most people do not experience side effects with insulin treatment. If you do experience side effects that worsen and persist, contact your doctor immediately, especially if you see signs of low potassium levels in the blood, irregular heartbeats, cramps, and weakness.

Injection site reactions may occur. This can include redness, irritation, and pain at injection sites.

Insulin can cause low blood sugar (hypoglycemia), which can show symptoms of cold sweats, shaking, hunger, blurred vision, increased heartbeat, dizziness, or tingling feet/hands.

Carrying a diabetic candy, glucose tablets, or a sugary drink (non-diet) in case of hypoglycemic side effects. To prevent hypoglycemia from occurring, be sure to eat meals regularly and do not skip meals. Consult your doctor for instructions in the event you miss a meal.

Hyperglycemia is another side effect that may also occur. Symptoms include increased thirst, increased urination, flushing, rapid breathing, drowsiness, confusion, and fruity breath. Speak with your doctor if you experience symptoms, as your dosage may need to be adjusted.

Serious allergic reactions when taking insulin are rare. In the event that you experience symptoms such as itching/swelling, body rash, trouble breathing, or dizziness, seek medical attention immediately.

All Humulin R insulin side effects listed above are not complete. Speak to your doctor or pharmacist about possible side effects.

Warnings & Precautions

Humulin R should not be used to treat children under 2 years old or children with type 2 diabetes of any age.

Do not use Humulin R if:

  • Substance appears cloudy, slightly colored, contains particles or thickened
  • If you medication was previously frozen
  • If medication is expired

Syringes and pens should not be shared as they are meant to be single-patient only. Sharing pens and needles can lead to the spread of infection and disease.

Make sure you are following your doctor’s instructions for your specific needs. Read the patient leaflet, especially after refills, provided by the pharmacy to ensure you have an understanding of instructions and preparation. If you have questions regarding Humulin R, speak to your doctor, pharmacist, or medical expert.

Before administering a dose of insulin, clear the area of injection with a cotton swab and rubbing alcohol.

Rotate injection sites to avoid skin problems such as lumps, pits, or thickened skin.

Insulin regular should be injected under the skin in the abdomen, upper thigh, upper arm, or buttocks as instructed by your doctor or nurse.

Do not rub the injection site after injecting.

Do not inject into skin that appears red, itchy, swollen or damaged.

Do not inject into a muscle or vein as this can result in low blood sugar (hypoglycemia).

Humulin R should be stored at room temperature.

Insulin should be taken 30 minutes before meals. Since Humulin R is fast-acting, you should not start eating directly after injection as this can result in hypoglycemia.

Do not use insulin regular with an insulin pump.

Speak with your doctor if your condition worsens or does not improve from the use of this diabetes medication.

Humulin R may be mixed with other medications such as a longer-acting insulin. Your doctor will provide direction as to which products can be mixed with your treatment.

Follow your treatment plan provided by your doctor and measure each dose carefully. By modifying the amount of insulin dose can drastically affect blood sugar levels.

Speak to your pharmacist on how to properly dispose of unused needles and pens safely.

Check blood sugar levels regularly using tools for blood sugar monitoring. Keep track of results and share with your doctor as the information is important in determining dosage requirements.

Blood sugar levels may be affected by factors such as surgery, exercise, stress, illness, and alcohol. Skipping meals can also lead to low blood sugar levels Speak to your doctor about how to proceed if you miss a meal or dose.

Wear or carry identification that lets others know you have diabetes.

Cost & Ordering Information

Buy Humulin R Through Buy Canadian Insulin

Buy Canadian Insulin helps patients access prescription medication options through participating pharmacy partners.

Pricing may vary depending on product strength, quantity selected, supplier availability, and participating pharmacy partner pricing policies.

Some patients may find pricing through participating pharmacy partners that differs from certain U.S. retail pharmacy prices.

Available services may include:

  • Pricing options based on quantity selected
  • Prescription processing through participating pharmacy partners
  • Shipping options available across eligible U.S. delivery locations
  • Ordering support through phone, email, or live chat
  • Multiple quantity options depending on prescription authorization and supplier availability

A valid prescription is required for prescription medications.

Prescription orders are subject to review by a licensed healthcare professional and pharmacist before dispensing, where applicable.

Shipping timelines may vary depending on prescription review requirements, inventory availability, destination location, and carrier services.

Prescription Medication Discounts and Coupons

Eligible first-time customers may use coupon code FIRST10 during checkout for qualifying orders, subject to current promotional terms and conditions.

Have a Prescription?

Patients may explore available prescription options through participating pharmacy partners.

Available ordering features may include:

  • Pricing options based on quantity selected
  • Multiple quantity options depending on prescription details and supplier availability
  • Shipping options with tracking availability when provided by the carrier
  • Customer support assistance through phone, email, or live chat
  • Online and phone ordering availability
  • Licensed pharmacist consultations available for customers who have questions regarding their medication orders

A valid prescription is required before prescription medication can be dispensed.

Save 10% on your first qualifying order with coupon code FIRST10.

Shipping and Storage Information

Humulin R requires refrigerated storage before first use.

Store refrigerated between 2°C and 8°C (36°F to 46°F). Do not freeze. Do not use the product if it has been frozen.

Special packaging is used to help maintain recommended storage conditions during shipment.

Cold-Chain Shipping Notice

This product requires special packaging to maintain its integrity during the shipping process. DO NOT USE THIS MEDICATION if the attached temperature indicator shows that the medication was exposed to temperatures below 2°C or above 8°C, and contact the pharmacy immediately.

Always follow the storage instructions provided by the dispensing pharmacy and product manufacturer.

Contact Buy Canadian Insulin

For questions regarding prescription processing, product availability, shipping timelines, pharmacist consultations, or account support, contact Buy Canadian Insulin customer support:

Phone: 1-888-525-1815

Fax: 1-888-234-1275

Email: info@buycanadianinsulin.com

Customer Support Hours

Monday-Friday: 7am – 10pm CST

Saturday & Sunday: 9am – 5pm CST

Business Address

Buy Canadian Insulin

1026 Manitoba Avenue, Suite 1001

Selkirk, MB R1A 4M2

Canada

About Buy Canadian Insulin Services

Buy Canadian Insulin works with participating pharmacy partners to help patients access prescription medications and related healthcare products.

Product availability, pricing, and shipping timelines may vary depending on supplier inventory, participating pharmacy partner availability, and destination location.

Some prescription orders may be fulfilled through licensed pharmacy partners located in Canada or other international fulfillment locations depending on product availability.

A valid prescription is required for prescription medications.

Licensed pharmacist consultations are available for customers who have questions about their medication orders.

Orders are packaged according to pharmacy handling and shipping procedures.

Have a prescription?

Order Humulin R Vials online today and enjoy a host of benefits, including:

  • Cost Savings: Buy Humulin R Vials at significantly lower prices than in the US prices
  • Bulk Order Discounts: Save more on bulk orders of Humulin R Vials (up to 90-day supply)
  • Reliable Express Shipping: Fast and discreet delivery shipped right to your doorstep
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  • Easy & Secure Ordering: Seamless online or phone ordering at 1-888-525-1815
  • SAVE 10% on first order with coupon code: FIRST10

Frequently Asked Questions

There are two available strengths of Humulin R: Humulin R U-100 and Humulin R U-500. They contain 100 units of insulin per 1 mL and 500 units of insulin per 1 mL, respectively. There are currently two different vial sizes available for the Humulin R U-100 strength: a 3 mL vial and a 10 mL vial. Both vials contain 100 units per 1 mL, so the 3mL vial contains 300 units of insulin human recombinant, and the 10 mL vial contains 1,000 units of insulin human recombinant. The Humulin R U-500 is available in a 20 mL vial containing 10,000 units.

A vial of Humulin should be stored either at room temperature or in the refrigerator. Each vial, once opened, is good for use for 31 days. After this time period, the vial of Humulin R should be disposed of, regardless of if any medication still remains within the vial.

Humulin R insulin should be kept at room temperature, not exceeding 86°F (30°C). However, it may also be refrigerated. Patients that choose to refrigerate their Humulin R, are recommended to remove the medication from the colder temperatures and allow the insulin to reach room temperature before injecting to avoid discomfort.

As a short-acting insulin, Humulin R typically begins to work within about 30 minutes after it’s been injected.

Patients that use Humulin R should be sure to eat within 30 minutes of injecting this medication. Using insulin without having a meal to balance the individual’s blood glucose levels results in a higher risk of that patient experiencing hypoglycemia, which can become very serious if left untreated.

Humulin R is a short-acting insulin due to its ability to begin working within about 30 minutes after being injected. Due to the nature of short-acting insulins, the effects of Humulin R will also only last the patient for about three to six hours.

Humulin R insulin should be injected into the fatty layer of tissue under the skin about 30 minutes before having a meal. The most common injection sites for Humulin R and many other types of insulin are the belly, the back sides of the upper arms, or the patient’s tops or outsides of their thighs. Patients should not use the same injection site two times in a row to avoid skin-related complications. Due to Humulin R being a short-acting insulin and working rapidly, patients injecting this medication should be sure to eat after using Humulin R to avoid the risk of hypoglycemia.

If a patient who is using Humulin R insulin has forgotten to inject the medication before a meal, they should inject that dose as soon as they remember to do so. However, if a significant amount of time has passed and their next dose is approaching soon, they should not inject a double dose of Humulin R to compensate for the skipped dose before.

Patients that are using Humulin R to manage their diabetes will often inject the medication about three times per day, sometimes more, before consuming a meal. When using Humulin R, patients should follow their doctor’s instructions exactly, as each individual’s experience will vary. Additionally, different patients will have different requirements regarding the frequency and dosage of their medication.

Yes. Humulin R insulin is available as an over-the-counter insulin option, and it may also be prescribed by a patient’s physician. Please speak to your doctor or pharmacist if you have any additional questions about its availability.

Yes. Humulin R is available as an over-the-counter insulin option, and it may also be prescribed by a patient’s physician. Please speak to your doctor or pharmacist if you have any additional questions about its availability.

Many medications, herbs, supplements, and over-the-counter drugs may affect a person’s glucose metabolism. This will end up impacting the way in which their doctor instructs them to use Humulin R. There are many antibiotics, antidepressants, angiotensin II receptor blocking agents, corticosteroids, lipid-lowering medications, and other such drugs that may affect how the insulin works within a patient’s body. Thyroid replacement therapy and alcohol will also impact the way in which a patient must manage their diabetes with Humulin R. Please discuss all current over-the-counter and prescription medications, herbal supplements, and any other drugs or substances you may be consuming before beginning treatment.

Due to how insulin functions within the body, weight gain may occur in patients who are using Humulin R or any other types of insulin therapy. Insulin removes glucose from a patient’s blood, preventing them from having hyperglycemia, the condition in which an individual’s blood sugar levels are too high. However, insulin also tends to store any extra sugars as belly fat. This can result in patients using insulin experiencing weight gain.

The amount of Humulin R that a patient will need to take for the management of their diabetes will be determined by their prescribing physician. The amount of Humulin R that a patient will need will depend on any comorbid conditions they may have, their level of physical activity, their usual diet habits, and other various factors.

Disclaimer

Buy Canadian Insulin provides educational information about medications and health conditions for informational purposes only. This content is not intended to replace professional medical advice, diagnosis, or treatment. Prescription medications require valid prescription review and processing through participating pharmacy partners. Product availability, pricing, and shipping timelines may vary. Consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.

Price Match Guarantee

Price Match Guarantee

We’re dedicated to offering you the best value on every medication. If you discover a lower price on the same product at another verified Canadian online pharmacy, we’ll match it—so you can shop with confidence knowing you’re always getting a fair deal.

Eligibility Criteria

  • The pharmacy must be a licensed Canadian online provider with a verifiable address.
  • The competitor’s price must be active and current (not from past or upcoming promotions).
  • The product must match exactly in strength, pack size, quantity, manufacturer, and country of origin.
  • Requests must be made before completing your order—we cannot adjust prices after purchase.
  • Price matching does not apply to used or expired products.
  • Requests can be submitted via live chat or phone before checkout.

Note: Price matching does not currently apply to Mounjaro®, Ozempic®, or Saxenda®. This policy may be revised in the future.
Kenneth Fill, PharmD, MBA

Kenneth Fill, PharmD, MBA, is a clinical pharmacist specialist and medical writer with a strong background in ambulatory care, pharmacogenomics, and medical content development. Based in the state of Michigan, he provides expert guidance on chronic disease state management. Kenneth completed his PharmD and MBA at the University of Toledo and pursued post-graduate residency training in ambulatory care and community-based pharmacy. His diverse background also includes academic detailing, clinical education, and interdisciplinary collaboration to enhance patient outcomes.

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