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Metformin Hydrochloride, Linagliptin
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Product of Canada.
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Jentadueto Overview and Mechanism of Action

Jentadueto is a brand-name medication that stands as a cornerstone treatment for type 2 diabetes, a condition marked by the body’s struggle to efficiently utilize insulin, leading to elevated blood sugar levels. This innovative combination drug merges linagliptin and metformin hydrochloride into one tablet, streamlining the diabetes management process and potentially enhancing patient adherence to their treatment plan.

Type 2 diabetes arises from the body’s inability to produce sufficient insulin or effectively use the insulin it produces. Insulin is crucial for moving glucose from the bloodstream into cells, converting it into energy. Inadequate insulin function results in glucose accumulation in the blood, which, if left unmanaged, can lead to severe health issues such as heart disease, kidney damage, and nerve damage over time.

Jentadueto addresses these challenges by offering a dual-action approach to blood sugar regulation:

  • Linagliptin inhibits the dipeptidyl peptidase-4 (DPP-4) enzyme, slowing the breakdown of GLP-1, a hormone that increases insulin production in response to high blood sugar levels. This component does not directly stimulate insulin production but supports the body’s natural insulin response mechanism.
  • Metformin hydrochloride complements linagliptin by decreasing glucose production in the liver and reducing glucose absorption in the intestines, while also improving insulin sensitivity.

This combination not only aids in lowering elevated blood sugar levels but also assists in achieving better control over A1C levels, providing a comprehensive solution for managing Type 2 diabetes.

Dosage Guidelines for Jentadueto

Starting Dosage for Adults

Tailored to the individual’s current treatment plan and familiarity with metformin, the initial dosage aims for optimal efficacy with minimal side effects.

  • New to metformin: Start with 2.5mg/500mg twice daily.
  • Existing metformin users: Adjust based on current dosage, e.g., if taking 1000mg twice daily, start with Jentadueto 2.5mg/1000mg twice daily.

Jentadueto XR (Extended-Release)

Adjust dosage based on response and tolerability, with a maximum of 5mg/2000mg daily. Initial dose for metformin-naïve patients is 5mg/1000mg once daily.

Dosage Adjustments

Increase doses gradually to enhance gastrointestinal tolerance. Doses should be taken consistently with meals.

Before Starting Jentadueto

Ensure kidney health with a renal function test (eGFR), with ongoing monitoring.

Special Considerations

  • Consult your doctor for dosage adjustments if taking other diabetes drugs to avoid hypoglycemia.
  • Not approved for individuals under 18 years of age.

Storage: Maintain tablets at room temperature, between 68°F and 77°F (20°C and 25°C), in their original container.

Administration Instructions Simplified

Take Jentadueto tablets orally with meals to ensure optimal absorption. Swallow tablets whole without splitting or crushing. This straightforward method helps maintain the medication’s effectiveness and supports consistent blood sugar management.

Key Considerations

Ensuring proper administration and storage of Jentadueto is crucial for its effectiveness. The medication’s design simplifies the diabetes management process, potentially enhancing adherence and improving patient outcomes. Regular consultations with healthcare providers are essential to adjust dosages and address any concerns, ensuring a tailored approach to diabetes management.

By focusing on these simplified administration instructions and key considerations, you maintain essential patient guidance while removing unnecessary details about the tablet’s appearance and packaging. This approach keeps the content focused on practical, actionable information for users.

Medication Side Effects, Warnings, and Special Precautions

Jentadueto is an important drug for managing Type 2 diabetes but, like all drugs, it comes with potential side effects and requires adherence to certain precautions:

Common Side Effects

  • Nasal congestion or a runny nose
  • Throat irritation
  • Diarrhea
  • Vitamin B12 deficiency over long-term use, necessitating annual blood monitoring
  • Joint pain, a potential side effect of DPP-4 inhibitors
  • Skin reactions, including blisters

Serious Side Effects and Warnings

  • Allergic Reactions: Immediate medical attention is required for symptoms such as swelling of the face, tongue, or throat, difficulty breathing, or hives.
  • Lactic Acidosis: Characterized by weakness, dizziness, stomach discomfort, and muscle cramps. This condition is rare but serious.
  • Pancreatitis: Severe stomach pain, nausea, and vomiting indicate this serious condition.
  • Hypoglycemia: Especially when used with sulfonylurea or insulin, symptoms include headaches, drowsiness, dizziness, confusion, sweating, and a rapid heartbeat.
  • Heart Failure: Symptoms such as shortness of breath, difficulty breathing, fluid retention, and fatigue warrant immediate attention.

Immediate Actions for Severe Side Effects

Seek urgent medical care for severe reactions, including significant allergic reactions, sudden vision loss, blurred vision, heart-related symptoms (e.g., irregular heartbeats, shortness of breath), severe headaches, confusion, or any signs of pancreatitis or heart failure.

Information on Contraindications & Special Precautions


  • Severe Renal Impairment: Not recommended for patients with an eGFR of less than 30 mL/min/1.73 m^2 due to increased risk of metformin accumulation and lactic acidosis.
  • Metabolic Acidosis/Diabetic Ketoacidosis: Jentadueto should not be used in patients with these conditions, as it requires immediate treatment different from Jentadueto.
  • Allergies: Contraindicated in individuals with known hypersensitivity to linagliptin, metformin hydrochloride, or any other drug component, which could lead to severe allergic reactions.

Special Precautions

  • Lactic Acidosis Risk: Monitor for signs of lactic acidosis; discontinue Jentadueto if suspected.
  • Pancreatitis: Be vigilant for symptoms; discontinue use if pancreatitis is diagnosed.
  • Heart Failure: Use cautiously in patients with risk factors for heart failure; monitor for signs and symptoms.
  • Hypoglycemia Risk with Insulin or Sulfonylureas: Monitor blood sugar levels closely; dosage adjustments may be necessary.
  • Renal Function Monitoring: Regularly assess kidney function before starting and during treatment with Jentadueto.
  • Alcohol Consumption: Advise patients to limit alcohol intake due to increased risk of lactic acidosis.
  • Use in Specific Populations: Not approved for individuals under 18 years of age. Nursing mothers should consult their healthcare provider due to the potential for metformin to pass into breast milk.

Before Use

Healthcare providers should review the patient’s medical history and current drugs to identify any potential contraindications or need for dose adjustments. Regular monitoring and patient education on recognizing symptoms of serious conditions are crucial to ensure the safe use of Jentadueto.

Medication Interactions

Jentadueto’s effectiveness and safety can be influenced by its interaction with other drugs and substances. It’s essential for managing potential risks and optimizing therapeutic outcomes. Key interactions include:

  • Carbonic Anhydrase Inhibitors (e.g., topiramate, zonisamide, acetazolamide, dichlorphenamide): These can alter blood bicarbonate levels, increasing the risk of lactic acidosis when used with Jentadueto. Close monitoring is advised.
  • Drugs Affecting Metformin Clearance (e.g., ranolazine, vandetanib, dolutegravir, cimetidine): Such medications may affect how metformin is eliminated from the body, potentially raising the risk of lactic acidosis. Consideration of alternative treatments or additional monitoring may be necessary.
  • Alcohol Consumption: Excessive intake can enhance metformin’s effect on lactate metabolism, leading to an increased risk of lactic acidosis. Patients are advised to limit alcohol consumption.

Patients should inform their healthcare provider about all medications, supplements, and significant lifestyle factors, including alcohol use, to prevent adverse interactions. This proactive communication is crucial for adjusting treatment plans as needed and ensuring the safe use of Jentadueto in managing Type 2 diabetes.

Pharmacy Coupon & Pricing

Effective management of diabetes significantly depends on the accessibility and affordability of essential medications. Jentadueto, a key medication for regulating blood sugar levels, is crucial in this regard. Given the notably high cost of drugs in the United States, securing Jentadueto at a more affordable price can greatly assist patients in maintaining their prescribed treatment regimens.

Buy Canadian Insulin(BCI) is a prescription referral service that collaborates with licensed and reputable Canadian pharmacy partners. This partnership aims to provide American patients with the opportunity to order Jentadueto without the financial burden often associated with high retail prices in the U.S.

The US prices listed below are based on the current prices available on GoodRx, a widely used resource for finding the best prices for medications in the United States. This comparison underscores the potential savings for patients who opt to order Jentadueto from Canada.

Example of Savings on Jentadueto Consider the cost savings for Jentadueto 500mg/2.5mg:

  • In the US (GoodRx): The price for 60 tablets of Jentadueto 500mg/2.5mg is approximately $665.
  • Through BCI: The same 60 tablets are available for only $139.

This example illustrates a significant saving opportunity, where patients can save when they order Jentadueto through BCI compared to average US retail prices. These savings are not only beneficial for immediate financial relief but also ensure continued access to necessary medication for diabetes management.

StrengthQuantityCandianPriceUS PriceSavings (%)
500mg/2.5mg60 tabs$139$66579.1%
500mg/2.5mg120 tabs$260$132380.3%
500mg/2.5mg180 tabs$360$193381.4%

Jentadueto Coupon Code

Jentadueto Coupon Discount Code Special Offer: To further aid in managing healthcare expenses, BCI is offering an exclusive discount for purchasing Jentadueto online. Use the coupon code JENTAD10 at checkout to receive 10% OFF. This offer is valid for one use per customer, with a maximum savings of $50, and requires a minimum spend of $100.

By choosing Buy Canadian Insulin for your Jentadueto needs, US patients can significantly alleviate the financial burden of their diabetes medication. This initiative ensures that essential treatments are more accessible, offering substantial savings, especially for those without insurance coverage.


No, there is no generic equivalent of Jentadue available in the United States.

No, Jentadueto is not recommended for individuals with Type 1 diabetes or those experiencing diabetic ketoacidosis, as it is specifically formulated to improve glycemic control in adults with Type 2 diabetes.

While Jentadueto is effective in managing blood sugar levels, some users may experience side effects such as cough, sore throat, sinus pain, stuffy nose, upset stomach, weight gain, pancreatitis, diarrhea, and hypoglycemia.

Yes, Jentadueto carries a risk of lactic acidosis, a rare but serious condition. Symptoms include muscle pain or weakness, numbness in limbs, difficulty breathing, dizziness, and stomach pain. Immediate medical attention is advised if these symptoms occur.

Jentadueto should be taken daily with meals to reduce gastrointestinal side effects associated with metformin, part of its formulation. Dosage should be individualized based on the patient’s current health status and response to treatment.

Women who are pregnant, planning to become pregnant, or breastfeeding should consult their healthcare provider before starting Jentadueto, as its safety in these conditions has not been fully established.

If you miss a dose of Jentadueto, take it as soon as you remember, but skip the missed dose if it’s almost time for your next dose. Do not take two doses at one time to make up for the missed dose.

Long-term use of Jentadueto may lead to vitamin B12 deficiency in some individuals. It’s recommended to have your vitamin B12 levels checked annually while on this medication.

The dose of Jentadueto may need adjustment based on the patient’s response to treatment, kidney function, and other factors. Regular follow-up with a healthcare provider is essential to determine the appropriate dose.

Patients are advised to limit alcohol intake while taking Jentadueto due to the increased risk of lactic acidosis. Discuss with your healthcare provider for more personalized advice.

Before starting Jentadueto, inform your healthcare provider about all existing health conditions and medications to assess for potential contraindications and interactions.

Jentadueto should be stored at room temperature, away from direct light and moisture, to maintain its efficacy and shelf life.

Jentadueto may be used in combination with other diabetes medications, but it’s important to monitor for signs of hypoglycemia and adjust doses as necessary under the guidance of a healthcare provider.