Lotensin (Benazepril)

Prescription Required.

Product of Canada.

Express Ships from Canada.

Prescription Required.
Product of Canada.
Express Ships from Canada.

Lotensin (Benazepril)

What is Lotensin (Benazepril)?

Lotensin (benazepril) is an angiotensin-converting enzyme inhibitor medication that is most commonly prescribed for the treatment of high blood pressure (hypertension) as well as the prevention of certain kidney problems, heart attacks, and strokes. It may be used alongside other medications for treatment or by itself.

How is Lotensin Used?

This medication is an oral tablet that is typically taken once or twice per day. It may be taken with food or without, but patients should ensure that they are taking the medication exactly as instructed by their prescribing physician. It is important that patients also try to take this medication at the same time and in the same manner each day.

Lotensin may be used alone for treatment, or additional medications may also be used along with it based on the patient’s condition and the reason for which it was prescribed.

Storage

This medication should be stored at room temperature and should not be exposed to temperatures exceeding 86°F (30°C). Patients should ensure that the tablets remain in a tightly sealed container and remain protected from moisture.

Keep Lotensin out of the reach of children at all times.

Uses

Lotensin is prescribed for a variety of conditions, including but not limited to:

  • hypertension (high blood pressure)
  • cardiovascular disease
  • eclampsia
  • hypertensive congestive heart failure
  • hypertensive encephalopathy
  • hypertensive heart and renal disease (with or without congestive heart failure)
  • hypertensive heart disease
  • hypertensive renal disease
  • hypertensive retinopathy
  • pre-eclampsia
  • renovascular hypertension

How Does Lotensin Work?

This medication is an angiotensin-converting enzyme inhibitor (ACE inhibitor) that functions by blocking the action of angiotensin within the body. This chemical is responsible for causing constriction of the blood vessels, which can result in high blood pressure and other cardiovascular health risks. By inhibiting the action of the angiotensin within the body, Lotensin is able to cause the blood vessels to relax instead of constricting, allowing for improved blood flow and a reduction in one’s blood pressure.

Dosage

This medication is available in tablet form in the following strengths:

  • 10 mg
  • 20 mg
  • 40 mg

The prescribed dosage of Lotensin will vary based on the condition for which it was prescribed, as well as the patient’s age, weight, other medications they may be taking, and other comorbid conditions.

The most common dosage for adult patients at the start of treatment is a once-daily dose of 10 mg. If 10 mg once per day is not sufficient for lowering the individual’s blood pressure to the desired levels, this dosage will be increased to either 20 mg or 40 mg per day. The majority of patients using Lotensin to manage their high blood pressure is 20 mg per day.

Patients with impaired renal function or currently using diuretics or other medications to lower their blood pressure may be prescribed a lower dosage of Lotensin.

This medication should be taken exactly as instructed by the patient’s physician. If a dose is missed, the patient using this medication should try to take the missed dose as soon as they remember. However, if the next scheduled dose is occurring soon, patients should simply skip the missed dose and not double up on the medicine.

Overdose

If an overdose has occurred or is suspected, emergency medical attention should be sought as soon as possible due to the risk of serious adverse side effects.

Some of the possible symptoms of an overdose involving Lotensin include fainting, feeling lightheaded, or becoming extremely dizzy.

Side Effects

Lotensin is associated with a variety of side effects that vary in severity. Patients experiencing any concerning symptoms while using this medication should consult with their prescribing physician.

The most common side effects of taking Lotensin are as follows:

  • cough
  • dizziness
  • headache
  • tiredness

Some of the following additional side effects may also occur and should be discussed with your doctor if they remain persistent or increase in severity:

  • appetite loss
  • breathing difficulties
  • burning in the eyes
  • chest pain
  • dark-colored urine
  • feeling lightheaded
  • fever
  • hives
  • irregular heartbeat
  • jaundice (yellowing of the eyes or skin)
  • loss of movement
  • nausea
  • no or little urination
  • purple or red skin rash that spreads, peels, and blisters
  • skin pain
  • sore throat
  • stomach pain that is severe
  • stomach pain that occurs in the upper right side of the abdomen
  • swelling of the throat or face
  • tingling sensations
  • weakness

Please contact your doctor as soon as possible if you experience any of the following serious side effects associated with this medication:

  • abdominal pain with nausea and vomiting
  • angioedema
    • abdominal pain
    • breathing trouble
    • swelling of the throat, lips, face, or tongue
  • anxiety
  • decreased libido
  • difficulty sleeping
  • erectile dysfunction
  • infection symptoms
    • fever
    • sore throat
  • Stevens-Johnson syndrome (skin rash)
    • blistering
    • hives
    • peeling skin
    • raised welts
    • swelling of the face

Warnings & Precautions

Angioedema

Angioedema is a symptom of an allergic reaction that involves an individual experiencing swelling underneath the skin, including causing the tongue and throat to swell. Patients using Lotensin that are allergic to this medication or that have had allergic reactions to previous ACE inhibitor medications may experience this reaction and will need to seek emergency medical care if it occurs. Any patient using this medication that experiences swelling of the throat, tongue, or face should discontinue using the medication and should avoid using alternative ACE inhibitors in the future. Those who have previously experienced angioedema or had allergic reactions to ACE inhibitors are at an increased risk of experiencing this response to treatment with Lotensin.

Diabetes

Diabetic patients are at increased risk of experiencing imbalances in their blood glucose levels while using this medication. Additional instances of checking one’s blood sugar levels throughout the day may be necessary to manage this issue, and some patients with diabetes may require additional monitoring by their physician during treatment. Patients with diabetes should discuss with their doctor how using Lotensin may impact their condition as well as how their diabetes may impact the efficacy of the medication and treatment plan.

Hepatic Function

Those with impaired hepatic function or liver disease are at an increased risk of experiencing inflammation of the liver when using this medication. Patients with a history of impaired liver function should inform their physician of any liver-related health conditions before beginning treatment with Lotensin.

Hyperkalemia

Patients using this medication are at an increased risk of experiencing high levels of potassium in the blood, otherwise known as hyperkalemia. Although this may not cause symptoms in all individuals, signs of this condition occurring include the following: a tingling sensation in the limbs, unusual nervousness, confusion, and an irregular heartbeat. Patients that experience any of the symptoms of hyperkalemia should contact their prescribing physician as soon as possible. Most patients using Lotensin for treatment will have their potassium levels monitored on a regular basis.

Hypotension

A significant drop in one’s blood pressure is not uncommon when first beginning to use this medication for treatment. Symptoms of low blood pressure can include feeling lightheaded, dizzy, or about to faint. Individuals who experience vomiting or diarrhea, are on dialysis, have been excessively sweating, are taking diuretic medications, are on a diet that restricts salt intake, or are dehydrated are at an increased risk of low blood pressure occurring. Those who experience consistent or problematic low blood pressure levels should contact their physician.

Infection Risk

Some patients using this medication have experienced a reduction in white blood cell counts and therefore experience impaired immunity, resulting in an increased risk of infections. Any individuals using Lotensin who experience the following symptoms of infection should report them to their physician immediately: chills, dizziness that is persistent, fever, headaches, listlessness, neck stiffness, severe diarrhea, shortness of breath, or weight loss. Most patients using this medication will have regular bloodwork performed to monitor their blood cell counts during treatment.

Pediatric Use

It has not been determined if this medication is effective or safe for use in pediatric patients.

Pregnancy and Breastfeeding

Pregnant individuals should not use Lotensin due to the high risk of birth defects and fetal death that may occur. Patients currently taking Lotensin should avoid becoming pregnant and should report any new pregnancy to their physician immediately if it occurs while actively using the medication.

Lotensin is capable of passing into breast milk. Therefore, patients using this medication should be aware of the potential risks of breastfeeding a child. If you are using this medication and also want to breastfeed, please speak to your doctor about safer alternatives for treatment.

Renal Function

Individuals using Lotensin may experience changes in kidney function during treatment. Those that also use aliskiren are at an even higher risk of experiencing renal impairment. Any patients with a medical history that includes severe congestive heart failure, any type of kidney disease, or constriction of the blood vessels within the kidneys should inform their physician of these conditions before beginning treatment. Changes in dosage or additional monitoring of the patient’s renal function may be necessary for certain individuals.

Surgery

Lotensin is known to affect certain types of anesthesia. Any patient requiring surgery should inform their medical care team about the use of this medication before undergoing surgery and anesthesia.

Drug Interactions

Speak to your doctor about any medications or herbal supplements you are currently taking before beginning treatment with this medication. Discuss any concerns you may have with your doctor or a trusted pharmacist.

The following medications are known to interact with Lotensin and cause notable and sometimes side effects:

  • amlodipine
  • angiotensin-converting enzyme (ACE) inhibitors
  • angiotensin receptor blockers (ARBs)
  • blood pressure medications
  • bumetanide
  • calcium channel blockers
  • canagliflozin
  • captopril
  • celecoxib
  • chlorothiazide
  • chlorthalidone
  • dapagliflozin
  • diabetes medications
  • diclofenac
  • empagliflozin
  • enalapril
  • enalaprilat
  • eplerenone
  • everolimus
  • exenatide
  • felodipine
  • fosinopril
  • furosemide
  • glimepiride
  • glipizide
  • glyburide
  • gold
  • hydrochlorothiazide
  • ibuprofen
  • indapamide
  • indomethacin
  • insulin
  • irbesartan
  • ketoprofen
  • ketorolac
  • liraglutide
  • lithium
  • lixisenatide
  • loop diuretics
  • losartan
  • meloxicam
  • metformin
  • metolazone
  • moexipril
  • nabumetone
  • naproxen
  • nateglinide
  • nicardipine
  • nifedipine
  • non-steroidal anti-inflammatory drugs (NSAIDs)
  • olmesartan
  • perindopril
  • pioglitazone
  • potassium-based salt substitutes
  • potassium-sparing diuretics
  • potassium supplements
  • pramlintide
  • quinapril
  • ramipril
  • repaglinide
  • rosiglitazone
  • sacubitril
  • saxagliptin
  • sirolimus
  • sitagliptin
  • sodium thiomalate
  • spironolactone
  • telmisartan
  • temsirolimus
  • thiazide diuretics
  • torsemide
  • trandolapril
  • transplant medications
  • triamterene
  • valsartan

Alternative Medications

For patients who are unable to take Lotensin or experiencing significant adverse side effects, alternative medications may be used to treat some of the associated conditions for which this medication is commonly prescribed:

  • captopril (Capoten, Captoril)
  • enalapril (Vasotec)
  • fosinopril (Monopril)
  • lisinopril (Qbrelis, Prinivil, Zestril)
  • moexipril (Univasc)
  • quinapril (Accupril)
  • ramipril (Altace)
  • trandolapril (Mavik)

Frequently Asked Questions

This medication is primarily prescribed to treat hypertension (high blood pressure).

Lotensin is primarily used in the treatment of hypertension (high blood pressure), and its ability to lower a patient’s blood pressure also means that it is ideal for use in the prevention of heart attack, strokes, and kidney-related issues.

This medication should be taken orally and in the exact manner instructed by the patient’s physician. It may be taken with or without food but should be consumed with enough water to properly wash the medication down, and it is most commonly taken once or twice per day. Lotensin should be taken at the same time each day and in the same manner each day for maximum and consistent efficacy.

This medication should not be taken by any individuals that are pregnant, have diabetes and are currently taking aliskiren (or medications containing aliskiren); have kidney disease; have a history of angioedema; or are allergic to the medication, any of its ingredients, or other ACE inhibitors. Patients should be sure to discuss any medical history involving heart disease, diabetes, liver conditions, or kidney conditions with their physician before beginning treatment with this medication.

Patients taking this medication should avoid using salt substitutes, consuming potassium supplements or foods high in potassium, and drinking alcohol. Consuming any of these while using Lotensin may result in hyperkalemia or hypotension occurring as a result.

Although the occurrence of side effects is not frequent in those using this medication, the most commonly reported effects that may be experienced when first beginning treatment include drowsiness, dizziness, a headache, or feeling lightheaded. If these symptoms arise and begin to worsen, this should be reported to your doctor immediately.

If an overdose has occurred or is suspected, emergency medical attention should be sought immediately. Some of the possible symptoms of an overdose include fainting, feeling lightheaded, or becoming extremely dizzy.

Some of the potential supplements and medications that are contraindicated with Lotensin include the following: non-steroidal anti-inflammatory drugs (NSAIDs), lithium, diabetes medications, gold, Cox-2 selective agents, potassium-sparing diuretics, potassium supplements, and any medications or supplements that may impact the renin-angiotensin system within the body.

This medication is typically well-tolerated in children between the ages of 7 to 16 years old but should not be used in those below the age of 6. There is a lack of studies regarding the effects of Lotensin in geriatric patients, but it is recommended that individuals in this age bracket receive regular monitoring of their renal function. Patients that are pregnant should not use this medication. Individuals that are breastfeeding are recommended to either stop using Lotensin due to the potential risk to the breastfed infant or to stop breastfeeding and simply continue treatment with the medication.

Patients should not use this medication if they have had a serious reaction to other ACE inhibitors, if they have recently taken a heart medication known as sacubitril, or if they have hereditary angioedema. Patients that have diabetes or kidney disease and that use aliskiren should also avoid taking this medication.

Individuals that are pregnant should not use Lotensin. Patients using this medication should also not breastfeed due to the risks this poses to the breastfed infant.

Patients using this medication should exercise caution when sitting up from a lying position or standing up from a sitting position, as there is a significant risk of dizziness when adjusting to lowered levels of blood pressure. Additionally, this medication can decrease the amount of sweating that one experiences, so there is an increased risk of heat stroke. Individuals should be careful to remain well-hydrated and avoid becoming overheated in hot weather or during physical activities.

This medication is an angiotensin-converting enzyme inhibitor (ACE inhibitor). This type of medication functions by reducing the action of angiotensin within the body, a chemical that causes the constriction of one’s blood vessels. By inhibiting this chemical’s function, Lotensin is able to relax the patient’s blood vessels and thereby lower their blood pressure.

The active ingredient in this medication is benazepril. The inactive ingredients present in Lotensin include the following: titanium dioxide, talc, starch, propylene glycol, polysorbate 80, microcrystalline cellulose, magnesium stearate, lactose, iron oxides, hypromellose, hydrogenated castor oil, crospovidone, and colloidal silicon dioxide.

Lotensin is available in tablet form in strengths of 5 mg and 20 mg.

Most patients taking Lotensin begin with a starting dose of 10 mg once per day. If this dosage proves to be insufficient for managing an individual’s high blood pressure, the dosage may be increased to 20 mg or 40 mg once per day.