Cold-Chain Shipping Notice
This medication requires specialized cold-chain packaging to help maintain its quality and integrity during transit. Each shipment includes a temperature indicator to monitor storage conditions throughout the shipping process.
Do NOT use this medication if the attached temperature indicator shows that it was exposed to temperatures below 2°C (36°F) or above 8°C (46°F). If the temperature indicator shows that the acceptable temperature range has been exceeded, or if you have any concerns about the condition of your shipment upon arrival, do not use the medication and contact our pharmacy immediately for further instructions and assistance.
Please inspect your shipment and the temperature indicator as soon as it is delivered.
What is Lovenox (enoxaparin)?
Lovenox, also known as enoxaparin, is a low-molecular-weight heparin used prophylactically and in the treatment of deep vein thrombosis (DVT) and certain ischemic complications of unstable angina and myocardial infarction.
How does Lovenox work?
Lovenox (enoxaparin) is a low molecular weight heparin that acts as an anticoagulant by inhibiting clotting factor Xa and binding to antithrombin III (AT-III). The enoxaparin-AT-III complex irreversibly inhibits factor IIa (thrombin). Enoxaparin preferentially inhibits factor Xa.
Dosage
Lovenox is a clear to pale-yellow solution available in the following dosage forms and strengths:
100 mg/ml Concentration
- Single-Dose Prefilled Syringes: 30 mg/0.3 mL, 40 mg/0.4 mL
- Single-Dose Graduated Prefilled Syringes: 60 mg/0.6 mL, 80 mg/0.8 mL, 100 mg/1 mL
- Multiple-Dose Vial: 300 mg/3 mL
150 mg/ml Concentration
- Single-Dose Graduated Prefilled Syringes: 120 mg/0.8 mL, 150 mg/1 mL
The dosage varies by indication. For DVT, the general dosing is either 40 mg once daily or 30 mg every 12 hours for high-risk patients, such as those undergoing orthopedic surgery. For the treatment of DVT and PE, the recommended dose is 1 mg/kg every 12 hours or 1.5 mg/kg once daily in specific outpatient settings.
How to Use
Lovenox is often given as a subcutaneous injection. However, it can also be given intravenously under medical supervision. It should not be injected into a muscle.
Use a tuberculin syringe when using multiple-dose vials to ensure the withdrawal of the appropriate volume of the drug.
Lovenox prefilled syringes and graduated prefilled syringes are for single, one-time use only.
Subcutaneous injection
- Patients should be lying or sitting down for the injection.
- Do not expel the air bubble from prefilled syringes.
- Do not inject into bruised areas or through clothing.
- It should be injected in the right and left sides of the abdomen, at least 2 inches away from the belly button.
- Advance the entire length of the needle into the skin fold held between the thumb and forefinger.
- Avoid rubbing the injection site after administration, as this may increase bruising.
For detailed instructions on injection technique, please consult your pharmacist or doctor.
Storage
Store at 25°C (77°F). Temperature excursions are permitted between 15°C-30°C (59°F-86°F). Store in the original carton or packaging until ready to use. Do not store the multiple-dose vials for more than 28 days after the first use.
Overdosage
If there has been an overdose of Lovenox, seek medical attention due to the risk of hemorrhagic complications. Protamine sulfate is an antidote for Lovenox and other low molecular weight heparins that must be given through intravenous infusion under medical care. The amount and timing of Lovenox administration guide how much protamine sulfate is required for partial reversal. Protamine only partially reverses the anti-Xa activity of enoxaparin.
Side Effects
Common side effects of Lovenox may include:
- Nausea
- Diarrhea
- Anemia
- Confusion
- Pain or bruising around the injection site
Serious side effects are possible with Lovenox. Contact your doctor if you experience any of the following signs or symptoms of a serious side effect.
- Nerve problems
- Symptoms: back pain, numbness, tingling, or muscle weakness
- Bleeding problems
- Symptoms: throwing up or coughing up blood, blood in the urine, black or red tarry stools, bleeding from the gums, abnormal vaginal bleeding, abnormal bruising
- Bleeding in the brain
- Symptoms: sudden weakness on one side of the body, sudden severe headache, problems with speech or vision
- Severe allergic reaction
- Symptoms: hives, burning or itching skin, difficulty breathing, swelling of face, lips, or tongue
This is not a comprehensive list of all possible side effects. Contact your pharmacist or doctor for more information.
Warnings & Precautions
Boxed warning
Spinal or Epidural Hematomas
- Epidural or spinal hematomas may occur in patients who are anticoagulated with low molecular weight heparins or heparinoids and receive neuraxial anesthesia or undergo spinal puncture. These hematomas may result in long-term or permanent paralysis.
Other Warnings and Precautions
Increased Risk of Hemorrhage
- Use Lovenox with extreme caution in conditions with increased risk of hemorrhage, such as bacterial endocarditis, congenital or acquired bleeding disorders, active ulcerative and angiodysplastic gastrointestinal disease, hemorrhagic stroke, or shortly after brain, spinal, or ophthalmological surgery, or in patients treated concomitantly with platelet inhibitors.
Increased Risk of Bleeding following Percutaneous Coronary Revascularization Procedures
- To minimize the risk of bleeding following the vascular instrumentation during the treatment of unstable angina, non–Q-wave myocardial infarction, or acute ST-segment elevation myocardial infarction, adhere precisely to the intervals recommended between Lovenox doses.
Increased Risk of Bleeding in Patients with Concomitant Medical Conditions
- Lovenox should be used with care in patients with a bleeding diathesis, uncontrolled arterial hypertension, or a history of recent gastrointestinal ulceration, diabetic retinopathy, renal dysfunction, or hemorrhage.
Risk of Heparin-Induced Thrombocytopenia with or without Thrombosis
- Lovenox may cause heparin-induced thrombocytopenia (HIT) or heparin-induced thrombocytopenia with thrombosis (HITTS).
Interchangeability with other Heparins
- Lovenox cannot be used interchangeably (unit for unit) with heparin or other low molecular weight heparins as they differ in the manufacturing process, molecular weight distribution, anti-Xa and anti-IIa activities, units, and dosage.
Increased Risk of Thrombosis in Pregnant Women with Mechanical Prosthetic Heart Valves
- Using Lovenox for thromboprophylaxis in pregnant women with mechanical prosthetic heart valves may result in valve thrombosis.
Risk of Serious Adverse Reactions in Infants due to Benzyl Alcohol Preservative
- Serious and fatal adverse reactions, including gasping syndrome, can occur in neonates and low-birth-weight infants treated with benzyl alcohol-preserved drugs, including Lovenox multiple-dose vials.
Drug Interactions and Other Interactions
If possible, medications that increase the risk of bleeding should be discontinued during treatment with Lovenox. Examples of medications that increase the risk of bleeding are anticoagulants, platelet inhibitors including acetylsalicylic acid, salicylates, NSAIDs (including ketorolac tromethamine), dipyridamole, or sulfinpyrazone.
Contraindications
Lovenox is contraindicated in patients with any of the following:
- Active major bleeding
- History of immune-mediated heparin-induced thrombocytopenia (HIT) within the past 100 days
- Known hypersensitivity to enoxaparin sodium (e.g., pruritus, urticaria, anaphylactic/anaphylactoid reactions)
- Known hypersensitivity to heparin or pork products
- Known hypersensitivity to benzyl alcohol (which is in only the multiple-dose formulation of Lovenox)
Cost & Ordering Information
Buy Lovenox Through Buy Canadian Insulin
Buy Canadian Insulin helps patients access Lovenox (enoxaparin) prescription options through participating pharmacy partners.
Pricing may vary depending on the prescribed strength, quantity selected, supplier availability, and participating pharmacy partner pricing policies.
Some patients may find pricing through participating pharmacy partners that differs from certain U.S. retail pharmacy prices.
Available services may include:
- Pricing options based on prescribed Lovenox strengths and quantities
- Prescription processing through participating pharmacy partners
- Shipping options available across eligible U.S. delivery locations
- Ordering support through phone, email, or live chat
- Multiple quantity options depending on prescription authorization and supplier availability
A valid prescription is required for Lovenox. Prescription orders are subject to review and approval by a licensed healthcare professional and pharmacist before dispensing, where applicable.
Shipping timelines may vary depending on prescription review requirements, inventory availability, destination location, and carrier services.
Lovenox Discounts and Coupons
Eligible first-time customers may use coupon code FIRST10 during checkout for qualifying orders, subject to current promotional terms and conditions.
Ordering Information
Have a prescription?
Patients may explore available Lovenox prescription options through participating pharmacy partners.
Available ordering features may include:
- Pricing options based on quantity selected
- Multiple quantity options depending on prescription details
- Shipping options with tracking availability when provided by the carrier
- Customer support assistance through phone, email, or live chat
- Online and phone ordering availability
Storage and Shipping Information
Lovenox should be stored according to the product labeling and instructions provided by the dispensing pharmacy.
Orders are packaged according to pharmacy handling and shipping procedures. Packaging methods may be used to help maintain recommended storage conditions during transit when appropriate.
Patients should inspect their medication upon arrival and follow all storage instructions included with the product.
Customer Support & Business Information
For questions regarding Lovenox prescription processing, product availability, shipping timelines, or account support, contact Buy Canadian Insulin customer support:
Phone: 1-888-525-1815
Fax: 1-888-234-1275
Email: info@buycanadianinsulin.com
Customer Support Hours:
Monday-Friday: 7am – 10pm CST
Saturday & Sunday: 9am – 5pm CST
Business Address:
Buy Canadian Insulin
1026 Manitoba Avenue, Suite 1001
Selkirk, MB R1A 4M2
Canada
About Buy Canadian Insulin Services
Buy Canadian Insulin works with participating pharmacy partners to help patients access Lovenox and other prescription medications.
Product availability, pricing, and shipping timelines may vary depending on supplier inventory, participating pharmacy partner availability, and destination location.
Some prescription orders may be fulfilled through licensed pharmacy partners located in Canada or other international fulfillment locations depending on product availability.
Orders are packaged according to pharmacy handling and shipping procedures.
Frequently Asked Questions
Disclaimer
Buy Canadian Insulin provides educational information about medications and health conditions for informational purposes only. This content is not intended to replace professional medical advice, diagnosis, or treatment. Prescription medications require valid prescription review and processing through participating pharmacy partners. Product availability, pricing, and shipping timelines may vary. Consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
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