Mestinon SR (Pyridostigmine)
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$1399
Mestinon SR Pyridostigmine Bromide
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What is Mestinon SR?

Mestinon SR (pyridostigmine bromide) is a medication used to treat myasthenia gravis, a condition where muscles weaken due to problems with nerve signals.

It contains pyridostigmine, which helps stop the breakdown of a chemical called acetylcholine in the body. This chemical is important for muscle function.

Individual response times may vary. Patients should follow their healthcare provider’s dosing instructions and discuss treatment expectations with their healthcare team. It’s usually taken one to three times daily, depending on the patient’s needs, and provides extended symptom control due to its slow-release formulation. It’s important to take it regularly as prescribed by your doctor to maintain its benefits.

How Does Mestinon SR Work?

Mestinon SR works by stopping the breakdown of acetylcholine, a key chemical for muscle function. In myasthenia gravis, disrupted signal transmission causes muscle weakness.

Mestinon SR inhibits acetylcholine breakdown at nerve-muscle connections, reducing the breakdown of acetylcholine. This prolongs acetylcholine’s action and improves nerve-muscle transmission, enhancing muscle strength and symptom control.

Dosage Information and Usage

Dosage Form and Strengths of Mestinon SR

  • Each Mestinon SR tablet contains 180 mg of pyridostigmine bromide.
  • The tablets are light brown to pale yellow in color, capsule-shaped, and are marked with “W1” on one side and single-scored on the other side.
  • They are available in bottles of 30 tablets.

Usage

When taking Mestinon SR tablets, it’s important to swallow them whole with a glass of water.

Avoid crushing or cutting the tablets as they are designed to release the medication slowly throughout 8 to 12 hours.

Mestinon SR tablets are designed to gradually release medication, offering steady relief for individuals with myasthenia gravis. Each 180 mg tablet provides a prolonged effect compared to the immediate-release 60 mg tablet, lasting approximately 2 ½ times longer. Most patients effectively manage symptoms by taking one to three tablets daily, either once or twice, with doses ranging from 180 mg to 1.08 grams per day.

Your doctor will determine the right dose for you based on how you respond to the medication and any changes in your symptoms over time.

Storage Information

Store Mestinon SR tablets at room temperature, away from excessive heat, moisture, and direct sunlight. Find a secure place to keep them. When you have any leftover tablets, dispose of them safely. Always store medications where children and pets cannot reach them.

Side Effects of Mestinon SR

Common Side Effects

  • Blurred vision
  • Headaches
  • Vomiting
  • Rash
  • Abdominal pain
  • Diarrhea
  • Nausea

Serious but Rare Side Effects

  • Severe muscle weakness
  • Slurred speech
  • Vision difficulties
  • Worsening or no improvement in myasthenia gravis

Warnings and Precautions

  • If there’s no improvement with Mestinon SR, it could mean you’re either taking too little or too much. Overdosing can cause a cholinergic crisis, leading to severe muscle weakness that can impact breathing and be life-threatening. This crisis occurs when there’s too much acetylcholine at a nerve-to-muscle connection because the enzyme that breaks it down isn’t working properly.
  • It’s important to differentiate between a myasthenic crisis (worsening of myasthenia gravis) and a cholinergic crisis, as they need different treatments. Cholinergic crisis is a medical emergency that requires immediate evaluation by a healthcare professional. Patients experiencing severe muscle weakness, breathing difficulties, or other concerning symptoms should seek urgent medical attention.
  • Atropine can help manage gastrointestinal side effects, but it might hide signs of overdose, which could cause an unexpected cholinergic crisis.
  • Mestinon SR should be used cautiously in patients with conditions such as epilepsy, asthma, bradycardia, recent heart attack, vagotonia, hyperthyroidism, cardiac arrhythmias, or peptic ulcers.
  • Patients with megacolon or slow gastrointestinal motility should avoid large oral doses to prevent toxicity when motility is restored.

Drug Interactions With Other Medications

  • Atropine: This medication can block the actions of pyridostigmine on certain receptors in the body, called muscarinic effects. Atropine is sometimes used to reverse pyridostigmine’s effects in case of an overdose.
  • Depolarizing Muscle Relaxants: Pyridostigmine bromide doesn’t directly counteract muscle relaxants like succinylcholine. Instead, it can prolong their effects. These relaxants cause a temporary change in muscle contraction, known as depolarization.
  • Antibiotics: Certain antibiotics like neomycin, streptomycin, and kanamycin can boost the blocking effects on neuromuscular transmission. This means they can strengthen the muscle-blocking effects when used with pyridostigmine. Doctors should carefully adjust doses when using these antibiotics in patients with myasthenia gravis.
  • Anesthetics and Other Medications: Local anesthetics, certain general anesthetics, and antiarrhythmic drugs can impact nerve signal transmission to muscles. For people with myasthenia gravis, these medications should be used carefully or avoided, as they can disrupt neuromuscular transmission. If these drugs are necessary, the dose of pyridostigmine might need adjustment.
  • Combination Therapy: In severe myasthenia gravis, doctors might combine neostigmine (another medication used to treat myasthenia gravis) with pyridostigmine for short-term and long-term benefits. However, this combination should be used under close medical supervision due to possible side effects like reduced intestinal movement and increased toxicity risk.

Cost & Ordering Information

Buy Mestinon SR Through Buy Canadian Insulin

Buy Canadian Insulin helps patients access Mestinon SR (pyridostigmine bromide extended-release) prescription options through participating pharmacy partners.

Pricing may vary depending on product strength, quantity selected, supplier availability, and participating pharmacy partner pricing policies.

Some patients may find pricing through participating pharmacy partners that differs from certain U.S. retail pharmacy prices.

Available services may include:

  • Pricing options based on prescribed Mestinon SR quantities
  • Prescription processing through participating pharmacy partners
  • Shipping options available across eligible U.S. delivery locations
  • Ordering support through phone, email, or live chat
  • Multiple quantity options depending on prescription authorization and supplier availability

A valid prescription is required for Mestinon SR. Prescription orders are subject to review and approval by a licensed healthcare professional and pharmacist before dispensing, where applicable.

Shipping timelines may vary depending on prescription review requirements, inventory availability, destination location, and carrier services.

Mestinon SR Discounts and Coupons

Eligible first-time customers may use coupon code FIRST10 during checkout for qualifying orders, subject to current promotional terms and conditions.

Ordering Information

Have a prescription?

Patients may explore available Mestinon SR prescription options through participating pharmacy partners.

Available ordering features may include:

  • Pricing options based on quantity selected
  • Multiple quantity options depending on prescription details
  • Shipping options with tracking availability when provided by the carrier
  • Customer support assistance through phone, email, or live chat
  • Online and phone ordering availability

Explore our Mestinon SR options:

Quantity Price (USD)
180mg – 30 tabs $79.00
180mg – 60 tabs $150.00
180mg – 90 tabs $210.00

Discount on Mestinon SR

Eligible first-time customers may use code FIRST10 during checkout for promotional savings, subject to current promotional terms and availability.

Patients should review current pricing directly through the website or contact customer support for updated availability and fulfillment information.

Prescription Fulfillment & Shipping Information

Buy Canadian Insulin works with participating licensed pharmacy partners to help patients access prescription medications prescribed by their healthcare providers.

Prescription requests are reviewed by licensed pharmacists before dispensing. Orders are packaged according to pharmacy handling procedures to help maintain product integrity during transit.

Shipping timelines may vary depending on processing times, inventory availability, weather conditions, carrier delays, and destination location.

Patients should consult their healthcare provider before starting, stopping, or changing any treatment for myasthenia gravis.

Customer Support & Business Information

Phone: 1-888-525-1815

Fax: 1-888-234-1275

Email: info@buycanadianinsulin.com

Customer Support Hours:

Monday-Friday: 7am – 10pm CST

Saturday & Sunday: 9am – 5pm CST

Business Address:

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About Buy Canadian Insulin Services

Buy Canadian Insulin works with participating pharmacy partners to help patients access prescription medications and healthcare products.

Product availability, pricing, and shipping timelines may vary depending on supplier inventory, participating pharmacy partner availability, and destination location.

Some prescription orders may be fulfilled through licensed pharmacy partners located in Canada or other international fulfillment locations depending on product availability.

Orders are packaged according to pharmacy handling and shipping procedures.

Patients may contact customer support or consult with a pharmacist regarding prescription processing, product availability, and medication-related questions.

Have a prescription?

Order Mestinon SR online today and enjoy a host of benefits, including:

  • Cost Savings: Buy Mestinon SR at significantly lower prices than in the US prices
  • Bulk Order Discounts: Save more on bulk orders of Mestinon SR (up to 90-day supply)
  • Shipping: Fast and discreet delivery shipped right to your doorstep
  • Exceptional Customer Service: Have a question? We’re delighted to help via live chat, email, or phone
  • Easy & Secure Ordering: Seamless online or phone ordering at 1-888-525-1815
  • SAVE 10% on first order with coupon code: FIRST10

Frequently Asked Questions

Mestinon SR is a prescribed medication that helps ease myasthenia gravis symptoms like muscle weakness, double vision, and difficulty with speaking, chewing, swallowing, and breathing. It works by enhancing nerve-to-muscle communication, effectively managing the symptoms in the long run.

Yes, Mestinon may cause bradycardia. This means it can slow down your heart rate because of how it affects certain nerves in your heart. If you notice any changes in your heart rate or have concerns, it’s best to talk to your doctor.

No, Mestinon -SR tablets should not be cut in half. Doing so could disrupt the way the medication is released into your body, as these tablets are designed for sustained release over time. Cutting them may affect how well the medication works or cause it to release too quickly or unevenly in your system.

You can typically take Mestinon SR once or twice daily, as prescribed by your doctor. The exact frequency will depend on your individual medical needs and the severity of your condition.

No, Mestinon should not be crushed. Crushing Mestinon tablets can interfere with their intended slow-release mechanism, which is important for how the medication works in your body. It’s important to take Mestinon tablets whole, as prescribed by your doctor, to ensure you receive the medication in the proper way and at the correct rate.

The key difference between pyridostigmine and neostigmine lies in how quickly they take effect and how long they last. Pyridostigmine starts working slower but stays active in the body for a longer time compared to neostigmine. This means pyridostigmine may take longer to kick in but remains effective in the body for an extended period once it does. Some patients may find this advantageous, while others might prefer neostigmine for faster relief, even though it requires more frequent dosing.

When using Mestinon SR, steer clear of tasks needing clear vision and alertness, as it could lead to blurred vision or impact your thinking and reactions. This includes driving or operating machinery until you understand how the medication affects you. Also, refrain from alcohol consumption with Mestinon SR to lower the risk of specific side effects linked to pyridostigmine.

If you stop taking Mestinon SR without consulting your doctor, it may lead to a worsening of your myasthenia gravis symptoms.

Pyridostigmine usually begins to take effect within 30-40 minutes of ingestion and can provide relief for 3-6 hours. If you don’t experience an improvement in symptoms after taking it, or if the effects wear off quickly before your next dose, the medication may not be working effectively for you.

Mestinon SR can sometimes cause drowsiness or fatigue as a side effect. It’s important to be aware of how your body responds to the medication.

Disclaimer

Buy Canadian Insulin provides educational information about medications and health conditions for informational purposes only. This content is not intended to replace professional medical advice, diagnosis, or treatment. Prescription medications require valid prescription review and processing through participating pharmacy partners. Product availability, pricing, and shipping timelines may vary. Consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.

Price Match Guarantee

Price Match Guarantee

We’re dedicated to offering you the best value on every medication. If you discover a lower price on the same product at another verified Canadian online pharmacy, we’ll match it—so you can shop with confidence knowing you’re always getting a fair deal.

Eligibility Criteria

  • The pharmacy must be a licensed Canadian online provider with a verifiable address.
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  • The product must match exactly in strength, pack size, quantity, manufacturer, and country of origin.
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Note: Price matching does not currently apply to Mounjaro®, Ozempic®, or Saxenda®. This policy may be revised in the future.
Kenneth Fill, PharmD, MBA

Kenneth Fill, PharmD, MBA, is a clinical pharmacist specialist and medical writer with a strong background in ambulatory care, pharmacogenomics, and medical content development. Based in the state of Michigan, he provides expert guidance on chronic disease state management. Kenneth completed his PharmD and MBA at the University of Toledo and pursued post-graduate residency training in ambulatory care and community-based pharmacy. His diverse background also includes academic detailing, clinical education, and interdisciplinary collaboration to enhance patient outcomes.