Novolin GE 30 / 70 Penfill Cartridge 100 Units / mL
Novolin GE 30 / 70 Penfill Cartridge
Insulin Injection, Insulin Isophane Human Biosynthetic
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Product of Canada.

Express Ships from Canada.

Prescription Required.
Product of Canada.
Express Ships from Canada.

Novolin GE 40/60 represents a significant advancement in diabetes management, offering a unique blend of intermediate-acting insulin (insulin NPH) and fast-acting insulin (insulin regular). This premixed formulation mimics the body’s natural insulin release more closely, providing a more balanced and effective approach to blood sugar control.

Insulin, a vital hormone naturally produced in the pancreas, is crucial in regulating blood glucose levels. The pancreas, nestled behind the stomach, houses specialized cell clusters called islets. These islets are responsible for detecting glucose levels in the blood and releasing insulin accordingly to facilitate the storage and usage of glucose by the body’s cells.

However, in individuals with diabetes, this intricate system is disrupted. The body either fails to produce enough insulin or becomes resistant to its effects, leading to elevated blood sugar levels. This imbalance necessitates external insulin administration, typically through subcutaneous injections, to help manage and normalize blood glucose levels.

Novolin GE 40/60, with its dual-action profile, begins to take effect within 30 to 60 minutes post-injection. Its peak activity occurs between 2 to 8 hours, providing substantial control over blood sugar spikes, particularly after meals. The effects of this insulin preparation last for about 18 to 24 hours, ensuring extended glucose regulation.

The choice of insulin therapy is highly individualized, depending on various factors, including the patient’s lifestyle, diet, and the body’s response to different insulin types. Novolin GE 40/60 is particularly beneficial for those who have achieved stable blood glucose control and find this specific combination of intermediate and short-acting insulin to be the most effective.

It is crucial to understand that insulin therapy, including Novolin GE 40/60, is prescribed based on individual health needs and conditions. Therefore, it should never be shared with others, even if they exhibit similar symptoms. What works for one person may not be suitable for another and could potentially lead to adverse effects.

In addition to the 40/60 mixture, Novolin is available in other formulations, such as 50/50 and NPH, in both vial and cartridge forms. These options provide flexibility and allow for tailored treatment plans to meet the diverse needs of individuals with diabetes.

Always consult with your healthcare provider before making any changes to your insulin regimen. They can provide guidance and adjustments based on your unique health profile, ensuring safe and effective diabetes management.

How to Use Novolin GE 40/60 Penfill Cartridges

Using Novolin GE 40/60 Penfill Cartridges correctly is crucial for effective diabetes management. Here’s a step-by-step guide to ensure proper usage:

  1. Preparation: Before using the Penfill cartridge, wash your hands thoroughly. Check the insulin: it should be uniformly cloudy or milky after gently rolling the cartridge between your hands. Do not use if there are clumps or if the insulin appears clear.
  2. Inserting the Cartridge: Insert the Novolin GE 40/60 cartridge into your insulin pen according to the manufacturer’s instructions. Make sure it is securely in place.
  3. Priming the Pen: Prime the pen to ensure insulin flow. This means expelling air from the needle and cartridge. Dial a small dose (usually 2 units), point the pen upwards, and press the plunger. A drop of insulin should appear at the needle tip. If not, repeat this step until you see a drop, indicating the pen is ready for use.
  4. Setting the Dose: Dial your prescribed insulin dose carefully. Double-check the dose before injection.
  5. Choosing the Injection Site: Common injection sites include the abdomen, thigh, or upper arm. Rotate injection sites within the same region to reduce the risk of lipodystrophy (skin changes due to repeated injections at the same spot).
  6. Injecting the Insulin: Pinch the skin lightly (if advised by your healthcare provider), insert the needle at a 90-degree angle, and press the plunger slowly and steadily to inject the insulin. Hold the needle in place for about 10 seconds to ensure complete delivery.
  7. Disposing of the Needle: After injection, safely remove and dispose of the needle. Use a sharps container for disposal. Never reuse needles.
  8. Storing the Pen: Store the pen with the Novolin GE 40/60 cartridge at room temperature (not in the refrigerator) once in use. Keep it away from direct heat and light. Check the expiration date regularly and do not use past this date.
  9. Monitoring Blood Glucose: Regularly monitor your blood glucose levels as directed by your healthcare provider. This will help you understand how Novolin GE 40/60 affects your blood sugar and whether dose adjustments are necessary.
  10. Consulting Healthcare Providers: If you have any questions or encounter issues like inconsistent blood sugar levels, pain at the injection site, or allergic reactions, consult your healthcare provider immediately.

Side Effects of Novolin GE 30/70 Penfill Cartridge

Common Side Effects

These are typically mild and may diminish as your body adjusts to the medication. They include:

  • Hypoglycemia (low blood sugar): Symptoms can include shaking, sweating, rapid heartbeat, dizziness, hunger, headache, and irritability.
  • Injection site reactions: Redness, swelling, itching, or mild pain around the area where the insulin was injected.
  • Weight gain: Some people may notice a slight increase in weight when they start using insulin.
  • Mild swelling of hands and feet.

Serious Side Effects

Less common but more severe side effects require immediate medical attention. These include:

  • Severe hypoglycemia: Symptoms might be more intense, including confusion, seizures, or loss of consciousness.
  • Allergic reactions: Signs include rash, itching, swelling (especially of the face, tongue, and throat), severe dizziness, and trouble breathing.
  • Hypokalemia (low potassium levels): Symptoms can include muscle cramps, weakness, and irregular heartbeat.
  • Lipodystrophy: Changes in the skin at the injection site, like thickening or pitting of the skin.

Long-term Side Effects

With prolonged use, some individuals may experience:

  • Changes in fat tissue at the injection site, leading to skin thickening or pits at the injection site.
  • Potential worsening of diabetic retinopathy, a condition affecting the eyes.

Rare Side Effects

Although uncommon, some rare side effects might occur, such as:

  • Anaphylaxis: A severe, potentially life-threatening allergic reaction.
  • Edema: Swelling caused by excess fluid trapped in the body’s tissues.

Psychological Impact

Managing diabetes and regular insulin injections can sometimes lead to anxiety or depression.

Interactions with Other Medications

Novolin GE 30/70 can interact with other drugs, potentially leading to an increased risk of hypoglycemia or hyperglycemia.

Drug Interactions with Novolin GE 30/70 Penfill Cartridge

Medications that May Increase Blood Sugar Levels:

  • Corticosteroids (e.g., prednisone)
  • Thyroid hormones
  • Estrogens (such as in birth control pills)
  • Diuretics (especially thiazides)
  • Sympathomimetics (such as pseudoephedrine)
  • Certain antipsychotics (e.g., olanzapine)

Medications that May Decrease Blood Sugar Levels:

  • Oral diabetes medications (like metformin)
  • Certain blood pressure medications (ACE inhibitors, beta-blockers)
  • Alcohol (especially when consumed in large quantities)
  • Some antidepressants (like MAO inhibitors)
  • Aspirin and other salicylates

Medications that May Increase or Decrease Blood Sugar Levels:

  • Anticoagulants (like warfarin)
  • Certain antibiotics (like sulfonamides)
  • Lithium medications

Medications that May Mask the Symptoms of Hypoglycemia:

  • Beta-blockers (used for high blood pressure or heart conditions)

Interactions with Herbal Supplements and Over-the-Counter Medications:

  • Certain herbal supplements can affect blood sugar levels.
  • Over-the-counter medications, especially those for colds or allergies, may contain ingredients that affect blood sugar.

Alcohol Interaction:

  • Alcohol can unpredictably affect blood sugar levels, sometimes causing it to rise or fall.

Food Interactions:

  • Certain foods, especially those high in carbohydrates or sugar, can affect how insulin works in your body.

Lifestyle Factors:

  • Exercise and changes in daily routine can affect blood sugar levels and how insulin works.

Warnings and Precautions for Novolin GE 30/70 Penfill Cartridge

Hypoglycemia (Low Blood Sugar)

  • The most common and potentially serious side effect of insulin therapy.
  • Symptoms include dizziness, sweating, confusion, and palpitations.
  • Always carry a source of fast-acting sugar and monitor blood sugar levels regularly.

Hyperglycemia (High Blood Sugar)

  • Can occur if the insulin dose is too low, missed, or if there is increased stress or illness.
  • Symptoms include frequent urination, thirst, and high blood sugar readings.
  • Requires prompt adjustment of insulin dosing and possibly medical attention.

Allergic Reactions

  • Rare but can be serious. Symptoms include rash, shortness of breath, and swelling.
  • Seek immediate medical attention if you experience these symptoms.

Insulin Adjustments

  • Changes in diet, exercise, or daily routine can affect insulin needs.
  • Regular consultation with a healthcare provider is necessary for dose adjustments.

Injection Site Reactions

Rotate injection sites to prevent lipodystrophy (skin thickening) and cutaneous amyloidosis (skin lumps).

Use in Specific Populations

  • Caution in pregnant or breastfeeding women, as insulin needs may change.
  • Elderly patients and those with renal or hepatic impairment may require dose adjustments.

Drug Interactions

Be aware of potential interactions with other medications (as detailed in the Drug Interactions section).

Travel and Time Zone Changes

Traveling across time zones may require adjustments in insulin timing and dosage.

Illness or Stress

Illness, especially with nausea and vomiting, can affect insulin needs.

Stress, both physical and emotional, can impact blood sugar levels.

Alcohol Consumption

Alcohol can affect blood sugar levels and the effectiveness of insulin.

Storage and Handling

Store the cartridges as recommended. Improper storage can affect insulin efficacy.

Emergency Situations

Have a plan for emergencies, such as sick days or natural disasters, to ensure continuous insulin availability.

Storage and Handling of Novolin GE 30/70 Penfill Cartridges

Proper storage and handling of Novolin GE 30/70 Penfill Cartridges are crucial for maintaining its efficacy and safety. By following these guidelines, you can ensure that your insulin remains effective and safe for use in managing your diabetes.

Before Use

  • Store unused Penfill cartridges in a refrigerator, maintaining a temperature between 2°C to 8°C (36°F to 46°F).
  • Ensure the cartridges are not placed near the freezer compartment to avoid freezing.
  • If a cartridge freezes, do not use it, as freezing can compromise the effectiveness of the insulin.

In Use

  • Once you start using a cartridge, it can be kept at room temperature, not exceeding 30°C (86°F), for up to 4 weeks.
  • Keeping the cartridge at room temperature can reduce discomfort during injection as cold insulin can be painful to inject.

Protection from External Factors

  • Protect the cartridges from direct heat and light. Exposure to extreme temperatures can degrade the insulin.
  • Do not use the insulin if it has been exposed to excessive heat or direct sunlight.
  • Inspect the insulin regularly; it should be clear and colorless. Do not use if you notice any discoloration, cloudiness, or if there are visible particles.

Safe Handling Practices

  • Wash your hands thoroughly before handling the cartridges.
  • When preparing to use, check the label to ensure it’s the correct type of insulin.
  • Gently roll the cartridge between your hands to warm the insulin to room temperature before use.
  • Avoid shaking the cartridge vigorously as this can cause air bubbles or frothing, which might affect the insulin dose


  • Dispose of used cartridges safely. Do not throw them in household trash.
  • Use a sharps disposal container or follow local regulations for disposal of medical waste.

Traveling with Insulin

  • When traveling, keep the cartridges in a cool bag. Avoid leaving them in a car or any place where they might be exposed to extreme temperatures.
  • Carry a doctor’s note for travel, especially for air travel, to avoid issues at security checkpoints.

Frequently Asked Questions

It’s not recommended to mix Novolin GE 30/70 with other insulins unless advised by a healthcare professional. Mixing can alter the action profile of both insulins.

If you miss a dose, consult your healthcare provider for advice. Do not double the next dose to make up for a missed one, as this can lead to hypoglycemia.

Insulin should be clear and colorless. If it appears cloudy, thickened, or has particles, it should not be used. Also, if it has been stored improperly or is past its expiration date, it may not be effective.

Consult your doctor before using Novolin GE 30/70 during pregnancy or while breastfeeding. Your insulin needs may change during these periods.

Changes in physical activity and diet can affect your insulin needs. Consult your healthcare provider for guidance on adjusting your dose in these situations.

Yes, but keep it in a cool bag and avoid exposing it to extreme temperatures. Carry a doctor’s note for ease during travel, especially for air travel.

Signs of insulin overdose include extreme weakness, blurred vision, sweating, tremors, stomach pain, and confusion. If you suspect an overdose, seek medical attention immediately.

Any change in insulin should be made cautiously and only under medical supervision. Your doctor will provide specific instructions on transitioning to Novolin GE 30/70.

If you have kidney or liver problems, your insulin needs may change. Consult with your healthcare provider for appropriate dosing.

Symptoms of an allergic reaction include rash, itching, swelling, severe dizziness, and trouble breathing. If you experience these symptoms, seek medical attention immediately.