Novolin GE 30 / 70 Vial 100 Units / mL
Novolin GE 30 / 70 Vial
Insulin Injection, Insulin Isophane Human Biosynthetic
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Prescription Required.

Product of Canada.

Express Ships from Canada.

Prescription Required.
Product of Canada.
Express Ships from Canada.

What is Novolin 30/70 Insulin

Novolin 30/70 is a premixed insulin which contains both a fast-acting insulin (insulin regular) and an intermediate-acting insulin (insulin NPH). Patients who take this insulin have their blood sugar levels managed and have found this ratio of both insulin types works best for them.

Novolin 30/70 typically begins to work between 30-60 minutes of injection, has a maximum effect between 2-8 hours and stops working up until 18-24 hours.

Your doctor may have prescribed Novolin 30/70 for conditions that may not be listed below however it is primary taken by those who are diagnosed with either type 1 or type 2 diabetes. If you are unsure why you taking this medication then you should consult with your doctor. Do not stop taking it unless instructed by your doctor.

This medication is not to be shared with others even if they have the same symptoms. This medication can be harmful to those who have not received a prescription from their doctor to use it.

How Novolin GE 30 / 70 Vial Works

Novolin GE 30 / 70 Vial operates through a sophisticated mechanism, combining two types of insulin to regulate blood sugar levels in individuals with diabetes. This medication’s efficacy lies in its unique formulation, which includes 30% regular insulin (fast-acting) and 70% isophane insulin (intermediate-acting). Understanding how each component functions is key to appreciating the overall effectiveness of Novolin GE 30 / 70.

Fast-Acting Regular Insulin

The fast-acting regular insulin in Novolin GE 30 / 70 is designed to mimic the body’s natural insulin response to food intake. Upon injection, this insulin quickly gets absorbed into the bloodstream, typically beginning to work within 30 minutes. Its primary role is to manage the rapid rise in blood sugar levels that occur after eating. By doing so, it helps prevent the spikes in blood sugar that can be particularly harmful to individuals with diabetes. This rapid action is crucial for controlling post-meal hyperglycemia and is an essential part of daily blood sugar management.

Intermediate-Acting Isophane Insulin

The intermediate-acting isophane insulin component of Novolin GE 30 / 70 provides a more prolonged, steady release of insulin. This aspect of the medication starts working several hours after injection and continues to maintain its effect for a significant part of the day. It’s particularly effective in managing blood sugar levels between meals and during the night. This sustained action helps to prevent the blood sugar lows and highs that can occur when fast-acting insulin wears off, ensuring a more stable and consistent blood sugar level throughout the day.

Synergistic Effect

The combination of these two types of insulin in Novolin GE 30 / 70 allows for a more comprehensive approach to blood sugar management. The fast-acting insulin quickly addresses immediate blood sugar spikes, while the intermediate-acting insulin provides ongoing control. This dual approach is particularly beneficial for individuals who experience significant fluctuations in their blood sugar levels throughout the day and night.

Administration and Absorption

Novolin GE 30 / 70 is typically administered via subcutaneous injection. The absorption rate and onset of action can be influenced by various factors, including the injection site, blood flow, temperature, and physical activity. Common injection sites include the abdomen, thighs, and upper arms. Rotating injection sites is recommended to prevent tissue hardening or fat breakdown, which can affect insulin absorption.

Tailored Treatment

The treatment regimen involving Novolin GE 30 / 70 is highly individualized. Healthcare providers consider various factors, including the patient’s lifestyle, diet, blood sugar patterns, and sensitivity to insulin, to determine the most effective dosing schedule. Regular monitoring and adjustments are often necessary to ensure optimal blood sugar control.

In conclusion, Novolin GE 30 / 70 Vial offers a balanced and effective solution for managing blood sugar levels in individuals with diabetes. Its combination of fast-acting and intermediate-acting insulin components addresses both immediate and long-term blood sugar control needs, providing a comprehensive approach to diabetes management. As with any insulin therapy, close collaboration with healthcare professionals is essential for safe and effective use.

Dosage and Administration

Administering Novolin GE 30 / 70 Vial correctly is crucial for achieving optimal blood sugar control in individuals with diabetes. This section provides detailed guidance on dosage, administration techniques, and important considerations to ensure safe and effective use of this medication.

Determining the Correct Dosage

The dosage of Novolin GE 30 / 70 Vial varies significantly among individuals, depending on several factors:

  • Blood Sugar Levels: Regular monitoring of blood sugar levels is essential to determine the appropriate insulin dosage.
  • Diet and Lifestyle: Changes in diet, exercise, and daily routine can affect blood sugar levels and, consequently, insulin requirements.
  • Other Health Conditions: Coexisting medical conditions and other medications can influence insulin needs.
  • Individual Response: Each person’s response to insulin can differ, necessitating personalized dose adjustments.

Administration Techniques

Novolin GE 30 / 70 Vial is administered via subcutaneous injection. Proper injection technique is vital for ensuring effective absorption of insulin:

  • Injection Sites: The abdomen, thighs, and upper arms are common injection sites. Rotating sites is recommended to prevent lipodystrophy.
  • Injection Depth: The insulin should be injected into the fatty tissue under the skin, not into muscle or blood vessels.
  • Syringe and Needle: Use a U-100 insulin syringe and a new needle for each injection to ensure accuracy and reduce the risk of infection.

Timing of Injections

The timing of Novolin GE 30 / 70 injections is critical for maintaining stable blood sugar levels:

  • Pre-Meal Injections: Typically, Novolin GE 30 / 70 should be injected 30 minutes before a meal to allow the fast-acting component to work effectively.
  • Consistency: Maintaining a consistent schedule for injections helps in achieving better blood sugar control.

Mixing and Preparing the Insulin

Before use, Novolin GE 30 / 70 Vial should be gently rolled between the palms to ensure proper mixing of the insulins. Avoid vigorous shaking as it can cause frothing, which may interfere with the correct measurement of the dose.

Storage and Handling

Proper storage of Novolin GE 30 / 70 is essential for maintaining its efficacy:

  • Unopened Vials: Store in a refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze.
  • Opened Vials: Can be kept at room temperature, below 30°C (86°F), for up to 42 days.
  • Protection from Light and Heat: Keep the vial away from direct sunlight and extreme heat.

Adjustments and Monitoring

Regular consultation with healthcare professionals is necessary for ongoing adjustments to the insulin regimen. This includes:

  • Routine Blood Sugar Monitoring: Frequent checks allow for timely adjustments in dosage.
  • Response to Therapy: Regular medical evaluations help assess the effectiveness of the treatment and make necessary changes.

Special Considerations

Certain situations require special attention when using Novolin GE 30 / 70:

  • Illness or Stress: These conditions can alter blood sugar levels, necessitating dosage adjustments.
  • Pregnancy: Insulin needs may change during pregnancy and require close monitoring.
  • Travel: Time zone changes can affect the timing of insulin injections.

Side Effects and Safety Profile

Like all medications, Novolin GE 30 / 70 Vial can cause side effects, although not everyone will experience them. Understanding the potential side effects and safety profile of this insulin is crucial for patients and caregivers.

Common Side Effects

The use of Novolin GE 30 / 70 Vial may lead to some common side effects, which typically are mild and temporary. These include:

  • Hypoglycemia (Low Blood Sugar): The most common side effect, characterized by symptoms such as dizziness, sweating, confusion, and palpitations.
  • Injection Site Reactions: Redness, swelling, or itching at the injection site. Usually resolves within a few days.
  • Weight Gain: Can occur due to the anabolic effects of insulin.
  • Edema: Fluid retention leading to swelling in the limbs.
  • Mild Allergic Reactions: Such as skin rash or itching over the entire body.

Serious Side Effects

While rare, some serious side effects can occur, which require immediate medical attention:

  • Severe Hypoglycemia: Can lead to loss of consciousness, seizures, or death if not treated promptly.
  • Hypokalemia (Low Potassium Levels): Can cause muscle weakness, irregular heartbeat, and may be life-threatening.
  • Severe Allergic Reactions: Including anaphylaxis, a serious whole-body allergic reaction that requires emergency treatment.
  • Lipodystrophy: Changes in fat tissue at the injection site, leading to skin thickening or pits at the injection site.

Long-Term Safety Concerns

Long-term use of insulin, including Novolin GE 30 / 70, requires monitoring for potential long-term effects:

  • Cardiovascular Risks: Especially in patients with preexisting heart conditions.
  • Renal Function: Insulin metabolism can be affected in patients with renal impairment.
  • Vision Changes: Rapid changes in blood sugar levels can affect vision temporarily.

Safety in Special Populations

Certain populations may require extra caution:

  • Children and Adolescents: Safety and efficacy in pediatric patients have not been established for Novolin GE 30 / 70.
  • Elderly Patients: May be more sensitive to insulin effects and require careful dose adjustments.
  • Pregnant and Breastfeeding Women: Insulin needs may change during pregnancy and lactation.

Managing Side Effects

Effective management of side effects involves:

  • Education: Understanding the signs of hypoglycemia and how to treat it.
  • Regular Monitoring: Keeping track of blood sugar levels to adjust insulin doses accordingly.
  • Communication with Healthcare Providers: Reporting any persistent or severe side effects.

Preventive Measures

To minimize the risk of side effects:

  • Proper Injection Technique: Ensures the correct dose and reduces the risk of skin reactions.
  • Diet and Exercise: A balanced diet and regular exercise can help mitigate weight gain and improve insulin sensitivity.
  • Regular Check-ups: Ongoing medical supervision to adjust treatment as needed.

Drug Interactions

Potential Drug Interactions

  • Insulin Sensitizers: Medications like metformin, which increase insulin sensitivity, may require dose adjustments of Novolin GE 30 / 70 to prevent hypoglycemia.
  • Beta-Blockers: These can mask the symptoms of hypoglycemia, making it harder to recognize and treat.
  • Corticosteroids: Drugs like prednisone can increase blood sugar levels, potentially necessitating a higher insulin dose.
  • Thyroid Hormones: Changes in thyroid hormone levels can affect insulin requirements.
  • Other Medications: Inform your healthcare provider about all medications, including over-the-counter drugs and herbal supplements, as they may interact with insulin.

Foods or Activities to Avoid

  • Alcohol: Can unpredictably affect blood sugar levels and insulin requirements.
  • High Sugar Foods: Consuming large amounts of sugar can counteract the effects of insulin.
  • Excessive Exercise: Without proper adjustment of insulin dosage, intense or prolonged physical activity can lead to hypoglycemia.

Warnings & Precautions

Notify your doctor of any pre-existing medical conditions, allergies, any medications, supplements or over-the-counter drugs you are taking, if you are pregnant or expecting and other significant facts about your health. This information may be taken into consideration as it may impact dosage and how your body will respond.

  • Do not take insulin if it appears unusually thick, discolored, lumpy or grainy.
  • Do not take if bottle looks frosted, if it contains crystals.
  • Do not take if suspension remains clear after it’s been rolled between your hands.

Allergic reactions

Stop using this medication and seek medical attention if you are experiencing any serious allergic reactions such as swelling of the face or throat, difficulty breathing, wheezing, or body rash.

Blood Glucose Monitoring

It is important for patients using insulin to check their blood glucose levels regularly as recommended by their doctor. Blood glucose levels should also be tested in cases where there is a change in dose schedule due to a time zone difference, a missed meal or being under stress. If you are experiencing high or low blood sugar levels consistently then you should contact your doctor.

Changes at injection site

If you are injecting consistently at the same site you may shrink or thicken fatty tissue. To avoid this from happening, rotate injection sites regularly. Notify your doctor if you notice any skin pitting or thickening at injection sites.

Change in insulin requirements

Insulin requirements may require modification based on blood glucose levels. These may also include:

  • certain medical conditions
  • certain medications that can affect glucose levels in the blood
  • diet
  • exercise
  • illness
  • injury
  • stress
  • surgery
  • travelling over different time zones

Speak with your doctor about your current health and any changes that may affect blood glucose levels.

Diabetes identification

It is important to carry identification that lets other know you have diabetes and are taking insulin. This may include a card in your wallet, bracelet or necklace.

Drowsiness/Tiredness/Reduced Alertness

Low blood sugar may lead to a decrease in mental alertness or physical abilities. It is important to avoid operating heavy machinery, hazardous tasks or drive if you are experiencing low blood sugar.

Educate Family & Friends

Educate your family and friends about they should do if you experience hypoglycemia and symptoms. Instruct them on how to administer a glucagon emergency kit if you experience low blood glucose levels and lose consciousness.

Hypoglycemia

This may occur if you use too much insulin, miss a meal or exercise too much. Symptoms of hypoglycemia may include cold sweats, nervousness, shakiness, fast heartbeat, hunger, confusion, weakness, numbness or tingling in lips, tongue or fingers. Hypoglycemia may be treated by consuming foods that contain sugar. It is recommended to carry a glucose tablet, candy or sugary drink (non-diet) in case you experience symptoms of hypoglycemia.

Signs of Severe Hypoglycemia may include disorientation, loss of consciousness and seizures. For those who are unable to consume sugar by mouth during severe hypoglycemia may require a family or friend to inject them using an emergency glucagon kit.

Low Potassium

Insulin can also cause low levels of potassium. This may happen if you are experiencing vomiting or diarrhea due to illness or from certain medications that may cause low potassium. Symptoms of low potassium may include, leg cramps, slowed heartbeat, constipation or tiredness. If you experience any of these symptoms let your doctor know as low potassium levels can become be fatal.

Pregnancy or Breast feeding

During pregnancy, it is important to properly managed blood glucose levels. During the first trimester insulin levels usually decrease until the second and third when it is increased. Adjustments to insulin levels and diet may be required during breast feeding.

Insulin Storage

  • Keep unopened bottle of insulin refrigerated until needed.
  • Insulin is good until the expiry date on the label.
  • Never allow insulin to be frozen.
  • Keep out of reach from children or pets.
  • Insulin currently in use can be kept at room temperature for up to 28 days and then should be discarded.
  • Do not expose insulin to extreme heat or sunlight.

What form does this insulin come in?

Each vial of Novolin 70/30 contains 30 units of regular insulin and 70 units of insulin isophane, human biosynthetic – NPH insulin. It also contains non-medical ingredients including metacresol, phenol, hydrocholric acid and/or sodium hydroxide, glycerol, disodium phosphate dihydrate, protamine sulphate, zinc chloride and water for injection.

Who should not this insulin?

  • If you have an allergy to insulin or any ingredients that are contained in this medication.
  • Experiencing a diabetic coma.
  • Experiencing hypoglycemia (low blood glucose).

Frequently Asked Questions

Novolin GE 30 / 70 is a premixed insulin used to control high blood sugar in people with diabetes. It contains a mixture of intermediate-acting and fast-acting insulin.

Store unopened vials in a refrigerator (not in the freezer) and avoid exposing them to extreme heat or light. Once opened, the vial can be kept at room temperature for up to a month.

Consult your doctor as insulin needs may change during pregnancy and breastfeeding. It’s important to monitor blood sugar levels closely during these times.

If you miss a dose, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.

Novolin GE 30 / 70 is typically injected under the skin. Follow your healthcare provider’s instructions on dosage and administration.

Do not mix or dilute Novolin GE 30 / 70 with any other insulin or solution unless specifically instructed by your healthcare provider.

Symptoms of hypoglycemia include dizziness, sweating, confusion, and shakiness. Treat it by consuming fast-acting sources of sugar like glucose tablets, candy, or juice.

Yes, but plan ahead for time zone changes and carry an adequate supply. Keep it properly stored and carry it in your hand luggage if flying.

Avoid excessive alcohol consumption and be cautious with high-sugar foods. Monitor blood sugar levels closely when engaging in physical activity.

If you suspect an overdose, which can lead to severe hypoglycemia, seek immediate medical attention. Carry emergency contact information and inform others about your condition for quick assistance.