Repaglinide (Generic)
Select product strength & quantity:

Prescription Required.

Product of Canada.

Shipped from Canada.

Prescription Required.Product of Canada.Shipped from Canada.


Repaglinide is an antidiabetic drug belonging to the meglitinide class. It is used in adjunct to diet and exercise for the treatment of type 2 diabetes mellitus (T2DM), specifically in those who are non-insulin dependent. It works by lowering blood glucose and preventing hyperglycemia. Controlling hyperglycemia prevents downstream complications such as kidney damage, loss of limbs, blindness, heart attack, stroke, or nerve problems. It is important to keep control over diabetes to decrease the chance of experiencing related complications. Repaglinide should not be used in those with type 1 diabetes mellitus (T1DM).


Repaglinide works by decreasing blood glucose levels in the blood. Repaglinide exerts this effect by initiating insulin production in the pancreas. This mechanism requires functioning (ß) cells in the pancreatic islets, and therefore repaglinide does not work in patients with T1DM. The production of insulin depends on glucose and results in decreased concentrations of glucose.

Repaglinide shuts ATP-dependent potassium channels within the membrane of ß-cells. Inhibition of these potassium channels depolarizes the ß-cell, causing calcium channels to open. Increased influx of calcium causes the release of insulin. This phenomenon is highly selective to ion channels in certain tissues, so skeletal and heart muscle are not affected.