What is Resotran?
Resotran (prucalopride succinate) is a medication designed to help adult women who have chronic constipation that does not seem to have a specific cause.
It is especially useful when other laxatives have not worked well enough to provide relief.
Chronic idiopathic constipation means having long-term constipation without a clear or known reason. Resotran works by helping the muscles in your gut move more effectively.
It stimulates peristalsis, the wave-like movement of muscles in the intestines that helps push stool through the digestive system.
This can help you have more frequent bowel movements and feel like you have emptied your bowels.
A lower dose might work just as well for adults over 65, as their bodies may respond differently.
However, Resotran medication is not recommended for children or teenagers under 18.
Resotran should not be used by people who are allergic to its ingredients, those who are on dialysis (a treatment for severe kidney problems), and people with serious intestinal issues like blockages, holes in the intestine, or conditions such as Crohn’s disease or ulcerative colitis.
Dosage Information and Usage
Dosage Form and Strengths of Resotran Medication
Resotran is available as a film-coated tablet for oral use in two strengths: 1 mg and 2 mg.
They contain the active ingredient prucalopride succinate and lactose as a nonmedicinal ingredient.
Usage
The recommended dose of Resotran for adults is 2 mg once daily. If there is no bowel movement within 3-4 days, patients should inform their doctor, who may suggest an additional laxative for short-term use.
Elderly patients (over 65 years) usually start with a 1 mg dose once daily, which can be increased to 2 mg if necessary.
Patients with severe kidney problems should take 1 mg daily, while those with severe liver issues should also start with 1 mg, which can be increased if needed.
Do not give Resotran to children under 18. Take the tablets with or without food at any time of the day. Stop the treatment if Resotran does not work within the first 4 weeks.
Side Effects
When taking any medication, being aware of potential side effects is important. While most are mild and temporary, understanding what to expect can help you manage them effectively.
Here are some common side effects you might experience:
Common Side Effects
- Headache
- Abdominal pain
- Nausea
- Diarrhea (usually occurs on the first day and goes away within a day or so)
- Passing gas
- Enlarged abdomen or stomach
- Upset stomach
- Dizziness
- Tiredness
- Back pain
- Sinusitis (inflammation of the sinuses)
- Kidney and urinary disorders
Serious but Rare Side Effects
- Severe, persistent, or bloody diarrhea
- Worsening abdominal symptoms (such as severe pain)
- Strong, irregular, or racing heartbeat
- Chest pain
Warnings and Precautions
- Liver, kidney, or lung diseases: Talk to your doctor if you have any diseases affecting these organs because Resotran can affect how these organs function, and your doctor may need to adjust your treatment.
- Neurological or psychiatric problems: Inform your doctor if you have any conditions affecting your nervous system or mental health, such as seizures or depression, as Resotran can interact with these conditions and may require careful monitoring.
- Cancer, AIDS, or endocrine disorders: Discuss with your doctor if you have any of these severe conditions because these diseases can complicate the use of Resotran and may need special consideration.
- Heart problems: Let your doctor know if you have a history of abnormal heartbeats (arrhythmia) or heart disease, as Resotran can potentially affect your heart rhythm and overall heart function.
- Insulin-dependent diabetes: Tell your doctor if you have diabetes and rely on insulin, as your blood sugar levels may need to be closely monitored while using Resotran.
- Using oral contraceptives: If you get severe diarrhea while taking Resotran, your birth control pills may not work as well, so use an additional method of contraception to prevent unintended pregnancy.
- Galactose intolerance or related conditions: Avoid Resotran if you have problems digesting certain sugars, such as galactose intolerance, Lapp lactase deficiency, or glucose/galactose malabsorption. Resotran contains lactose, which can cause digestive issues in these conditions.
- Driving and using machines: Be cautious if you need to drive or operate machinery, as Resotran can cause dizziness or tiredness, impairing your ability to perform these tasks safely.
- Pregnancy and breastfeeding: Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as Resotran can pass into breast milk and may affect your baby. Your doctor will help you weigh the risks and benefits.
- Ketoconazole and erythromycin: These drugs can interact with Resotran and may increase its effects, leading to a higher risk of side effects. Your doctor may need to adjust your dose or monitor you more closely.
- Atropine-like substances: These medications can reduce the effectiveness of Resotran by affecting how it works in your body. Make sure to inform your doctor about all the medications you are taking.
Overdosage
If you suspect an overdose of Resotran, contact your regional Poison Control Centre immediately. In studies, even at doses up to 20 mg daily (which is ten times the recommended dose), Resotran was generally well tolerated.
However, taking too much Resotran medication can lead to exaggerated side effects such as headache, nausea, and diarrhea.
There is no specific treatment for a Resotran overdose, so care focuses on relieving symptoms and providing support as needed.
Correcting electrolyte imbalances may be necessary if there is significant fluid loss due to diarrhea or vomiting.
Drug Interactions With Other Medications
- Ketoconazole: This drug, which inhibits enzymes like CYP3A4 and P-glycoprotein (P-gp), can increase the levels of Resotran in the blood by about 40%. Other drugs like verapamil, cyclosporine A, and quinidine may have similar effects.
- Warfarin, alcohol, paroxetine, and oral contraceptives: Studies show that Resotran does not significantly affect the effectiveness of these medications.
- Digoxin: Resotran can decrease the bioavailability of digoxin by 10%, meaning the body absorbs less of this heart medication when taken with Resotran.
- Erythromycin: When taken with Resotran, erythromycin levels can increase by 40%, though this is likely due to the natural variability in how the body processes erythromycin.
- Probenecid, cimetidine, erythromycin, paroxetine: These drugs do not affect how Resotran is processed in the body so they can be taken together without significant interaction.
- Alcohol: Resotran’s effectiveness is unlikely to be significantly affected by alcohol.
- Atropine-like substances: These drugs can reduce the effects of Resotran, as they work against the same receptors in the gut that Resotran stimulates (5-HT4 receptors).
Alternative Medications
- Trulance (plecanatide)
- Motegrity (prucalopride)
- Linzess (linaclotide)
- Amitiza (lubiprostone)
- Lactitol
Cost & Ordering Information
Buy Resotran Through Buy Canadian Insulin
Buy Canadian Insulin helps patients access Resotran through participating pharmacy partners.
Pricing may vary depending on product strength, quantity selected, supplier availability, and participating pharmacy partner pricing policies.
Some patients may find pricing through participating pharmacy partners that differs from certain U.S. retail pharmacy prices.
Available services may include:
- Pricing options based on quantity selected
- Prescription processing through participating pharmacy partners
- Shipping options available across eligible U.S. delivery locations
- Ordering support through phone, email, or live chat
- Multiple quantity options depending on prescription authorization and supplier availability
Resotran requires a valid prescription from a licensed healthcare provider.
Prescription medications require review and approval by licensed healthcare professionals and pharmacists before dispensing, where applicable.
Shipping timelines may vary depending on prescription review requirements, inventory availability, destination location, and carrier services.
Resotran Discounts and Coupons
Eligible first-time customers may use coupon code FIRST10 during checkout for qualifying orders, subject to current promotional terms and conditions.
Have a Prescription for Resotran?
Patients may explore available Resotran ordering options through participating pharmacy partners.
Available ordering features may include:
- Pricing options based on quantity selected
- Multiple quantity options depending on prescription details
- Shipping options with tracking availability when provided by the carrier
- Customer support assistance through phone, email, or live chat
- Online and phone ordering availability
A valid prescription is required before Resotran can be dispensed.
Prescriptions may be submitted through one of the following methods:
- Upload through the website during checkout
- Email: info@buycanadianinsulin.com
- Fax: 1-888-234-1275
Pharmacist consultation may be available through participating pharmacy partners when appropriate.
About Buy Canadian Insulin Services
Buy Canadian Insulin works with participating pharmacy partners to help patients access Resotran and other prescription medications.
Product availability, pricing, and shipping timelines may vary depending on supplier inventory, participating pharmacy partner availability, and destination location.
Some Resotran orders may be fulfilled through licensed pharmacy partners located in Canada or other international fulfillment locations depending on product availability.
Orders are packaged according to pharmacy handling and shipping procedures.
Tracking information may be available when provided by the shipping carrier.
Customer Support & Business Information
For questions regarding Resotran availability, prescription processing, shipping timelines, or account support, contact Buy Canadian Insulin customer support:
Phone: 1-888-525-1815
Fax: 1-888-234-1275
Email: info@buycanadianinsulin.com
Customer Support Hours
Monday-Friday: 7am – 10pm CST
Saturday & Sunday: 9am – 5pm CST
Business Address
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1026 Manitoba Avenue, Suite 1001
Selkirk, MB R1A 4M2
Canada
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Frequently Asked Questions
Disclaimer
Buy Canadian Insulin provides educational information about medications and health conditions for informational purposes only. This content is not intended to replace professional medical advice, diagnosis, or treatment. Prescription medications require valid prescription review and processing through participating pharmacy partners. Product availability, pricing, and shipping timelines may vary. Consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
