What is Saxenda (liraglutide) ?
Saxenda, also known as liraglutide, is a daily injectable prescription medication. It is a glucagon-like peptide 1 (GLP-1) receptor agonist used for chronic weight management in addition to diet and exercise. Saxenda has proven efficacy and safety in those who are:
- Adult patients with an initial body mass index (BMI) of
- 30 kg/m2 (obese), or
- 27 kg/m2 (overweight) with at least one weight-related comorbid condition such as type 2 diabetes mellitus (T2DM), hypertension, or dyslipidemia)
- Pediatric patients aged 12 years and older with:
- A weight greater than 60 kg and
- A BMI corresponding to 30 kg/m2 for adults (obese) by international cut-offs
Saxenda has a few limitations to its use. These include:
- Co-administration with other GLP-1 receptor agonists or other products containing liraglutide
- Pediatric patients with T2DM, as safety and efficacy has not been confirmed in this population
- Combination with other weight loss medications, as safety and efficacy has not been confirmed when used with other products
How does Saxenda Work?
Saxenda is a GLP-1 receptor agonist, making it a mediator of calorie intake and appetite. The GLP-1 receptor appears throughout various parts of the brain that contribute to appetite regulation. In animal models, Saxenda administration produced liraglutide in areas of the brain that regulate appetite, including the hypothalamus.
Common side effects of Saxenda include:
- Injection site reactions
- Stomach pain
- Alterations to serum lipase levels
Warnings & Precautions