What is Xenical (Orlistat)?
Xenical, also known as orlistat, is a medication used for weight loss and weight management in patients with obesity. It is recommended for use in combination with a reduced-calorie diet.
How does Xenical work?
Xenical is a reversible inhibitor of enzymes known as gastrointestinal lipases. It forms covalent bonds with the active site of gastric and pancreatic lipases located in the lumen of the stomach and small intestine. These lipases are then unable to hydrolyze triglycerides into absorbable free fatty acids and monoglycerides. This non-absorption of dietary fats results in a calorie deficit.
Dosage and How to Use
Xenical is only available in 120 mg capsules.
Xenical should be taken as one 120 mg capsule three times a day with every main meal containing dietary fat. It should be taken during the meal or up to one hour after. If a meal is skipped or contains no dietary fat, that dose of Xenical can be omitted.
Store at room temperature (25°C or 77°F) and keep the bottle tightly closed. Temperature excursions between 15°C to 30°C (59°F to 86°F) are permitted. Do not use Xenical after the given expiration date.
If a significant overdose of Xenical is ingested, the patient should be observed for 24 hours. Based on human and animal studies, the lipase-inhibiting mechanism of Xenical should be rapidly reversible.
Previous studies have shown that patients experienced no adverse events with single doses of 800 mg or three times daily dosing of 400 mg for 15 days.
Common side effects of Xenical are:
- Fatty or oily stool
- Gas with oily discharge or oily spotting
- Urgent feeling to have a bowel movement
- Upset stomach
- Increased number of bowel movements
Potential serious side effects of Xenical are:
Lowered absorption of fat-soluble vitamins
- Take a multivitamin containing fat-soluble vitamins (A, D, E, K, and beta-carotene) once daily and at least 2 hours before or after taking Xenical.
Severe liver problems