Buy Xigduo from Canada
from$108.95
$600
Xigduo Dapagliflozin Propanediol Monohydrate, Metformin
Select product strength & quantity:
Prescription Required
Ships within 4-10 Business Days
Product of Canada
Secure Payment MethodsSecure checkout with Visa & Mastercard
Visa and Mastercard

SAVE 10% on Xigduo

with coupon code:

XIGDUO10

What is Xigduo?

XIGDUO is a combination oral prescription tablet. It contains dapagliflozin and metformin hydrochloride. Both these drugs are used for the management of type 2 diabetes mellitus. They are taken orally and help to reduce blood glucose levels.

How does Xigduo work?

XIGDUO contains dapagliflozin, which is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. It reduces the amount of glucose that is reabsorbed from the kidneys, lowering blood glucose concentrations in the blood.

XIGDUO also contains metformin, which is a biguanide. Metformin improves the body’s tolerance for glucose by reducing the absorption of glucose in the intestine, lowering glucose production in the liver, and improving the peripheral uptake and use of glucose.

What are the indications for Xigduo?

XIGDUO is indicated for the treatment of patients with type 2 diabetes mellitus. It is used with dietary measures and exercise to improve blood glucose levels in adults.

What is the suggested dosage of Xigduo?

XIGDUO is manufactured as a combination of dap­­agliflozin and metformin. It comes in the following dosing options:

  • 5 mg dapagliflozin and 850 mg metformin
  • 5 mg dapagliflozin and 1000 mg metformin

The starting dose of XIGDUO is one tablet taken twice a day. When starting XIGDUO, a combination of tablets should be taken so that the patient receives 10 mg of dapagliflozin daily and approximately the same dose of metformin they were taking before they started XIGDUO. The medication should be taken with food. The tablet should not be crushed, chewed, or cut. Dose titrations should be done while carefully monitoring for adverse events.

Warnings and Precautions

Hypotension

XIGDUO has been reported to cause a reduction in blood volume, leading to low blood pressure. It occurs more commonly in patients with renal impairment, older patients, and patients with preexisting low blood pressure. Therefore, ensure that any underlying volume deficit is replaced in the patient before starting XIGDUO. Monitor patients taking diuretics closely.

Lactic Acidosis

XIGDUO contains a drug called metformin. Metformin may accumulate in the body, causing a rare but potentially serious complication called lactic acidosis. The risk of developing lactic acidosis increases when the patient has liver failure, renal failure, congestive cardiac failure, sepsis, excessive alcohol intake, or dehydration. The onset of lactic acidosis may initially not be noticed, presenting with symptoms of tiredness, muscle soreness, shortness of breath, and abdominal pain. Laboratory tests show a low pH, high blood lactate, and an increase in the anion gap. If the diagnosis of lactic acidosis is considered, the patient should be admitted to the hospital for further management, and XIGDUO should be stopped immediately..

Hypoglycemia

XIGDUO, when used together with insulin or drugs that stimulate the secretion of insulin, can cause low blood sugar (hypoglycemia). Therefore, a lower dose of insulin or insulin secretion stimulators should be combined with XIGDUO.

Vitamin B12 deficiency

Metformin may cause a deficiency of Vitamin B12. Levels should be measured once a year.

Genital fungal infections

XIGDUO increases the risk of developing fungal infections on the genitals.

Bladder cancer risk

XIGDUO may increase the risk of bladder cancer. Do not start XIGDUO on patients with active bladder cancer. Use XIGDUO with care in patients who have a history of bladder cancer.

Special Populations

Renal Failure or Impairment

Dapagliflozin elimination is not affected by renal dysfunction. However, metformin is retained longer in the body in patients with renal dysfunction. Because of the accumulation, the use of XIGDUO is contraindicated in patients with renal dysfunction or renal failure or patients on dialysis. In addition, Dapagliflozin can cause a reduction in vascular blood volume. This may lead to symptomatic hypotension, which can be more severe in patients with renal dysfunction, in elderly patients, or those taking diuretics such as furosemide.

Hepatic Dysfunction

Metformin may cause lactic acidosis in patients with hepatic dysfunction or failure. As a result, XIGDUO should not be used in patients with ongoing liver dysfunction or elevated hepatic liver enzymes (ALT).

Elderly

Metformin blood levels are increased in elderly patients. This seems to be primarily driven by the loss of renal function seen in elderly patients. As a result, XIGDUO should not be started in patients who are older than 80 years of age without first checking their renal function.

Dapagliflozin can cause a reduction in vascular blood volume. This may lead to symptomatic hypotension, which can be more severe in patients with renal dysfunction, in elderly patients, or those taking diuretics such as furosemide.

Pediatrics

There are little long-term clinical data to determine the safety of dapagliflozin in pediatric patients. There are little data to guide the use of metformin extended-release formulations in the pediatric population.

Pregnancy

XIGDUO has not been studied in pregnant women, and the amount of drug expressed in breast milk is unknown. Therefore, use during pregnancy should only be considered if the potential benefit to the mother outweighs the risk to the fetus. XIGDUO should not be taken when breastfeeding.

Contraindications

XIGDUO is contraindicated in:

  • Patients with hypersensitivity to dapagliflozin or metformin
  • Established renal failure – eGFR < 30 ml/min/1.73m2
  • Patients on dialysis
  • Metabolic acidosis
  • Diabetic ketoacidosis

Side Effects

Common side effects of XIGDUO include:

  • Diarrhea
  • Nausea
  • Vomiting
  • Headache
  • Symptoms similar to a cold – stuffy nose, sinus pain, sneezing
  • Infections of the urinary tract
  • Genital fungal infections

Less common side effects include:

  • New or unusual pain in the muscles
  • Difficulty breathing
  • Pain in the stomach or vomiting
  • Abnormal heart rate
  • Changes in vision
  • Possible increased risk of bladder cancer

If any of these side effects are noticed, a doctor should be contacted immediately.

Drug Interactions

Certain drugs may interact with XIGDUO. These include:

  • Amiloride
  • Cimetidine
  • Morphine
  • Digoxin
  • Procainamide
  • Quinidine
  • Quinine
  • Ranitidine
  • Triamterene
  • Trimethoprim
  • Vancomycin

Care should be taken when using XIGDRO XR with other medications that can cause an increase in blood glucose levels. This includes:

  • Thiazides
  • Diuretics
  • Corticosteroids
  • Phenothiazines
  • Thyroid products
  • Estrogens
  • Oral contraceptives
  • Phenytoin
  • Nicotinic acid
  • Sympathomimetics
  • Calcium channel blocking drugs
  • Isoniazid

Cost & Ordering Information

Buy Xigduo XR Through Buy Canadian Insulin

Buy Canadian Insulin helps patients access prescription medications, including Xigduo XR, through participating pharmacy partners.

Pricing may vary based on the prescribed strength, quantity selected, supplier availability, and participating pharmacy partner pricing policies.

Some patients may find pricing through participating pharmacy partners that differs from certain U.S. retail pharmacy prices.

Available services may include:

  • Xigduo XR pricing options based on quantity selected
  • Prescription processing through participating pharmacy partners
  • Multiple quantity options, subject to prescription authorization
  • Shipping options available to eligible U.S. delivery locations
  • Customer support assistance through phone, email, or live chat
  • Online and phone ordering options

A valid prescription is required before Xigduo XR can be dispensed.

All prescription orders are reviewed and processed according to applicable pharmacy and regulatory requirements.

Shipping timelines may vary depending on prescription verification, product availability, destination location, and carrier services.

First-Time Customer Savings

Eligible first-time customers may use coupon code FIRST10 during checkout for qualifying orders, subject to current promotional terms and conditions.

How to Order Xigduo XR

Step 1: Search for Xigduo XR on the website and select the prescribed strength and quantity.

Step 2: Add the product to your cart and complete checkout by providing your contact information, shipping address, and payment details.

Step 3: Submit a valid prescription using one of the approved methods below.

How to Submit Your Prescription

Patients may submit a prescription using any of the following methods:

Upload: Through the prescription upload feature during checkout

Email: info@buycanadianinsulin.com

Fax: 1-888-234-1275

Prescription requirements and processing times may vary based on pharmacy partner requirements.

Customer Support

For questions about Xigduo XR, prescription submission, order status, or shipping information, contact:

Phone: 1-888-525-1815

Fax: 1-888-234-1275

Email: info@buycanadianinsulin.com

Hours of Operation

Monday–Friday: 7am – 10pm CST

Saturday–Sunday: 9am – 5pm CST

Business Address

Buy Canadian Insulin

1026 Manitoba Avenue, Suite 1001

Selkirk, MB R1A 4M2

Canada

About Buy Canadian Insulin

Buy Canadian Insulin works with participating pharmacy partners to help patients access prescription medications.

Product availability, pricing, fulfillment location, and shipping timelines may vary depending on supplier inventory, participating pharmacy partner availability, and destination location.

Some orders may be fulfilled through licensed pharmacy partners located in Canada or other international fulfillment locations, depending on product availability and pharmacy partner sourcing.

Frequently Asked Questions

XIGDUO is manufactured as a combination of dapagliflozin and metformin. It comes in the following dosing options:
  • 5 mg dapagliflozin and 850 mg metformin
  • 5 mg dapagliflozin and 1000 mg metformin

The starting dose of XIGDUO is one tablet taken twice a day. When starting XIGDUO a combination of tablets should be taken so that you receive 10 mg of dapagliflozin every day, and approximately the same dose of metformin you were taking before you started XIGDUO.

The XIGDUO should be taken by mouth twice a day, with food. The tablet should not be crushed, chewed, or cut. Dose changes should be done while carefully monitoring for adverse events.

Persons with renal dysfunction, renal failure, or those on dialysis, or those with a hypersensitivity to dapagliflozin or metformin should not take XIGDUO.

If you miss a dose of XIGDUO, try to take it as soon as possible, then continue with the usual medication schedule. However, if you are due to take your next dose soon, skip the dose you missed and continue with your regular medication schedule. Under no circumstances should you take a double dose of the medication to make up for the missed dose. If you are unsure about what to do, contact your doctor or local pharmacist to obtain advice.

Common side effects of XIGDUO include:
  • Diarrhea
  • Nausea
  • Vomiting
  • Headache
  • Symptoms similar to a cold – stuffy nose, sinus pain, sneezing
  • Infections of the urinary tract
  • Genital fungal infections
Less common side effects include:
  • New or unusual pain in the muscles
  • Difficulty breathing
  • Pain in the stomach or vomiting
  • Abnormal heart rate
  • Changes in vision
  • Possible increased risk of bladder cancer
If any of these side effects are noticed, a doctor should be contacted immediately.

If you experience severe side effects, immediately contact your doctor, or go to the nearest emergency health care facility.

XIGDUO should be stored away from children. It should be stored in a dry place at room temperature, away from heat, sunlight, and moisture. It should be stored in a closed container.

Disclaimer

Buy Canadian Insulin provides educational information about medications and health conditions for informational purposes only. This content is not intended to replace professional medical advice, diagnosis, or treatment. Prescription medications require valid prescription review and processing through participating pharmacy partners. Product availability, pricing, and shipping timelines may vary. Consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.

5 Star Excellence award from Shopper Approved for collecting at least 100 5 star reviews

Have a prescription?

Order Xigduo online today and enjoy a host of benefits, including:
  • Cost Savings: Buy Xigduo at significantly lower prices than in the US prices
  • Bulk Order Discounts: Save more on bulk orders of Xigduo (up to 90-day supply)
  • Reliable Express Shipping: Fast and discreet delivery shipped right to your doorstep
  • Exceptional Customer Service: Have a question? We’re delighted to help via live chat, email, or phone
  • Easy & Secure Ordering: Seamless online or phone ordering at 1-888-525-1815
  • SAVE 10% on first order with coupon code: FIRST10

Price Match Guarantee

Price Match Guarantee

We’re dedicated to offering you the best value on every medication. If you discover a lower price on the same product at another verified Canadian online pharmacy, we’ll match it—so you can shop with confidence knowing you’re always getting a fair deal.

Eligibility Criteria

  • The pharmacy must be a licensed Canadian online provider with a verifiable address.
  • The competitor’s price must be active and current (not from past or upcoming promotions).
  • The product must match exactly in strength, pack size, quantity, manufacturer, and country of origin.
  • Requests must be made before completing your order—we cannot adjust prices after purchase.
  • Price matching does not apply to used or expired products.
  • Requests can be submitted via live chat or phone before checkout.

Note: Price matching does not currently apply to Mounjaro®, Ozempic®, or Saxenda®. This policy may be revised in the future.
Kenneth Fill, PharmD, MBA

Kenneth Fill, PharmD, MBA, is a clinical pharmacist specialist and medical writer with a strong background in ambulatory care, pharmacogenomics, and medical content development. Based in the state of Michigan, he provides expert guidance on chronic disease state management. Kenneth completed his PharmD and MBA at the University of Toledo and pursued post-graduate residency training in ambulatory care and community-based pharmacy. His diverse background also includes academic detailing, clinical education, and interdisciplinary collaboration to enhance patient outcomes.