Cold-Chain Shipping Notice
This medication requires specialized cold-chain packaging to help maintain its quality and integrity during transit. Each shipment includes a temperature indicator to monitor storage conditions throughout the shipping process.
Do NOT use this medication if the attached temperature indicator shows that it was exposed to temperatures below 2°C (36°F) or above 8°C (46°F). If the temperature indicator shows that the acceptable temperature range has been exceeded, or if you have any concerns about the condition of your shipment upon arrival, do not use the medication and contact our pharmacy immediately for further instructions and assistance.
Please inspect your shipment and the temperature indicator as soon as it is delivered.
What is Zepbound (tirzepatide)?
Zepbound is an injectable medication manufactured by Eli Lilly that helps adults with obesity, or with excess weight (overweight) who also have weight-related medical problems, lose weight and keep it off. Zepbound should be used with a reduced-calorie diet and with an exercise plan. This medication is injected under the skin once per week.
Indications and Benefits of Zepbound
Zepbound can be prescribed for adults for long-term weight management (with diet and exercise) with a Body Mass Index (BMI) of 30 kg/m² or greater.
It is also indicated for those with a BMI of 27 kg/m² or greater who are experiencing weight-related health conditions such as high blood pressure, high cholesterol, type 2 diabetes, and obstructive sleep apnea.
Your doctor will review your medical history and assess your current health status to confirm if Zepbound is a suitable option for you.
What Are the Benefits of Zepbound?
- Zepbound (tirzepatide) is designed to help adults who are obese or overweight manage their weight more effectively.
- It can lead to a large amount of weight loss when used as prescribed.
- In studies, people using Zepbound lost an average of 18% of their body weight, with some losing up to 26.7% when taking higher doses.
- It works in two ways by targeting two hormones, GLP-1 and GIP, that help control hunger and manage how the body handles sugar.
- By controlling these hormones, Zepbound helps reduce appetite and keeps blood sugar levels more stable.
- It can also help improve other health problems linked to extra weight, such as type 2 diabetes and high blood pressure.
- People using Zepbound often feel more in control of their eating habits and experience fewer cravings.
- The treatment is given as a simple once-a-week injection, which makes it easier to stay on schedule.
- When combined with a balanced diet and regular exercise, Zepbound supports steady and long-lasting weight loss.
- It may also lead to better energy levels and improved overall wellness.
- Using Zepbound under the guidance of a healthcare provider ensures it is safe and effective for your personal health goals.
Fact Table
| Fact Category | Fact Details |
| Generic Name | Tirzepatide |
| Medication Class | Dual GIP and GLP-1 receptor agonist |
| Primary Use | Helps manage weight in adults who are obese or overweight, and may also help control blood sugar in people with type 2 diabetes |
| Additional Benefit | Can improve blood sugar levels, reduce appetite, and lower the risk of weight-related health issues like high blood pressure and heart problems |
| Available Form | Injectable solution |
| Method of Administration | Injected under the skin in the abdomen, thigh, or upper arm |
| Frequency | Once a week, preferably on the same day each week |
| Storage Instructions | Store in the refrigerator between 2°C to 8°C (36°F to 46°F). Do not freeze. Keep away from direct light and out of reach of children. |
| Pregnancy and Breastfeeding | Should not be used during pregnancy or breastfeeding unless a doctor advises it. Always consult a healthcare provider before use. |
| Drug Interactions | May interact with other diabetes treatments such as insulin or oral blood sugar-lowering drugs. Always inform your doctor about all medications you are taking. |
| Manufacturer | Eli Lilly and Company |
How It Works
Zepbound (tirzepatide) targets receptors for two natural gut hormones: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).
These hormones help regulate your appetite and how your body processes food. By mimicking these hormones, Zepbound (tirzepatide) can increase feelings of fullness and reduce your desire to eat, ultimately aiding in weight loss.
As a GIP (Glucose-Dependent Insulinotropic Polypeptide) and GLP-1 (Glucagon-Like Peptide-1) receptor agonist, Zepbound’s active ingredient, tirzepatide, activates crucial receptors involved in metabolic regulation. This action reduces hunger and appetite, decreases caloric intake, and slows gastric emptying, thereby helping to manage overeating and snacking.
Administered as a once-weekly subcutaneous injection, Zepbound is convenient and user-friendly, with adjustable dosages adjustable to fit individual patient needs, ensuring optimal treatment efficacy and minimal side effects.
Clinical Trials and Effectiveness
Weight loss results with Zepbound can vary. Factors such as starting weight, dose, diet, exercise, other medications, and health conditions can affect how much weight a person loses.
In clinical studies, people using higher doses of tirzepatide lost more weight on average than those using placebo. Your healthcare provider can help you understand what results may be realistic for your situation.
Dosage
The administration of Zepbound begins with a typical starting dose of 2.5 mg injected under the skin once a week. After 4 weeks or 1 month, your healthcare provider will raise the dose to 5 mg once a week. Depending on how you respond to the medication, your healthcare provider may increase or decrease the dose.
What Dosage Strengths Does Zepbound Come In?
The available strengths are:
- 2.5 mg in 0.6 ml
- 5 mg in 0.6 ml
- 7.5 mg in 0.6 ml
- 10 mg in 0.6 ml
- 12.5 mg in 0.6 ml
- 15 mg in 0.6 ml
The wide range of doses allows your healthcare provider to adjust the strength based on your progress and response to treatment.
Each pen is prefilled for single use and should be injected only once a week.
Dosage Chart
| Treatment Stage | Recommended Dose | Frequency | Purpose |
| Starting Dose | 2.5 mg once weekly | 4 weeks | To help your body adjust and reduce side effects |
| Step 2 | 5 mg once weekly | At least 4 weeks | Continued weight management after adjustment |
| Step 3 | 7.5 mg once weekly | At least 4 weeks | Gradual increase for better results |
| Step 4 | 10 mg once weekly | At least 4 weeks | Helps enhance weight loss effects |
| Step 5 | 12.5 mg once weekly | At least 4 weeks | For patients who need higher support |
| Maintenance Dose | 15 mg once weekly | Ongoing | Target dose for maximum effect if well tolerated |
Usage Guide
Zepbound is a once-weekly injection used to help with weight management in adults who are overweight or obese. It is given under the skin using a prefilled pen. You can inject it yourself or have someone help you.
How do you take Zepbound?
- Choose your injection site. You can inject it into your abdomen at least 2 inches away from your belly button, the front of your thigh, or the back of your upper arm if someone else is giving the injection.
- Rotate the injection site each week to prevent skin irritation or soreness.
- Clean the chosen area with an alcohol swab and let it dry completely before injecting.
- Remove the gray base cap of the pen without touching the needle.
- Place the clear base of the pen flat against your chosen site.
- Twist the top of the pen to unlock it and prepare for injection.
- Press and hold the purple button for about 10 seconds. You will hear a click when the injection starts and another click when it is complete.
- Check the window on the pen. The injection is done when you see the gray plunger has moved to the end.
- Remove the pen and place it immediately in a sharps disposal container. Do not throw it in the regular trash.
- If there is slight bleeding, gently press the area with cotton or gauze for a few seconds.
How Much Weight Do You Lose on Zepbound?
| Weekly Dose | Typical Weight Loss | Pounds Lost on Average | People Losing 5% or More |
| 5 mg | 15% | 36 lbs | 85% |
| 10 mg | 19.5% | 49 lbs | 89% |
| 15 mg | 20.9% | 52 lbs | 91% |
| Placebo | 2.4% | 5 lbs | 35% |
Side Effects
Common Side Effects
While Zepbound is an effective medication for weight management, it may cause some side effects, which are generally mild and manageable. These include:
- Nausea
- Diarrhea
- Vomiting
- Constipation
- Abdominal pain
- Stomach Pain
- Indigestion
Contact your doctor right away if these symptoms persist or worsen.
Serious Side Effects
In some cases, Zepbound can lead to more severe side effects, which require immediate medical attention. These include:
- Pancreatitis: Severe pain in the upper stomach spreading to the back, accompanied by nausea and vomiting.
- Gallbladder problems: Symptoms may include severe upper stomach pain, particularly after eating, and changes in stool color.
- Hypoglycemia: Symptoms like headache, dizziness, weakness, and confusion, particularly in patients taking other diabetes medications.
- Kidney problems: Indicated by reduced urine output, swelling in feet or ankles, and fatigue.
- Allergic reactions: Signs include hives, difficulty breathing, and swelling of the face, lips, tongue, or throat.
Patients experiencing these serious side effects should seek immediate medical care. It’s important for users of Zepbound to be aware of these potential risks and to communicate any unusual symptoms to their healthcare provider promptly.
Missed Dose
If you miss a dose of Zepbound, take it as soon as you remember if it has been only a short time since your scheduled day. If more than four days have passed, skip the missed dose and take your next dose on your regular day.
Do not take two doses close together because it may cause side effects. If you are unsure what to do, talk to your doctor or pharmacist for advice.
Overdose
Recognizing and Responding to Overdose
An overdose of Zepbound can lead to serious health complications. Recognizing the symptoms and responding promptly is crucial.
Symptoms of Overdose
- Severe Nausea and Vomiting: Excessive nausea and vomiting can be a sign of an overdose, leading to dehydration and electrolyte imbalances.
- Hypoglycemia: Symptoms of low blood sugar, such as dizziness, shaking, sweating, confusion, or loss of consciousness, can occur with an overdose, especially if used with other diabetes medications.
- Other Symptoms: Look out for any other unusual symptoms or severe reactions that are not typical for you.
Immediate Steps in Case of Overdose
- Seek Medical Attention: If you suspect an overdose, seek immediate medical attention. This is crucial, especially if severe symptoms are present.
- Inform Healthcare Providers: Provide emergency responders and healthcare providers with information about the overdose, including when Zepbound was taken and how much.
- Poison Control Consultation: Contact a poison control center for additional guidance on managing the overdose.
- Follow-Up Care: After initial treatment for an overdose, follow-up care may be necessary to ensure no long-term effects have occurred.
Being aware of the potential for drug interactions and the signs of an overdose can help ensure the safe use of Zepbound. Always maintain open communication with your healthcare providers about all medications and supplements you are taking, and do not hesitate to seek medical attention if you suspect an overdose.
Storage Information
It is crucial to store Zepbound properly in order to maintain its efficacy. The medication should be refrigerated consistently at temperatures ranging from 36°F to 46°F (2°C to 8°C).
You should throw out and discard Zepbound if not used within 21 days after removing it from the refrigerator.
Do not freeze Zepbound, as this can compromise the medication’s integrity. Additionally, the medication should be protected from light, which could potentially degrade its active ingredients. These storage conditions help ensure that each dose of Zepbound retains its full therapeutic potential.
Refrigerated Shipping & Storage Notice
Zepbound is a temperature-sensitive medication.
Special packaging may be used to help maintain recommended storage conditions during transit. Packaging may include insulated materials and temperature-supportive supplies when appropriate.
Shipping timelines may vary depending on prescription review, pharmacy processing, product availability, weather conditions, destination, customs processing, and carrier services.
Upon delivery, patients should inspect the package and follow the product-specific storage instructions. Zepbound should be stored in the refrigerator between 36°F and 46°F or 2°C and 8°C. Do not freeze. Do not use Zepbound if it has been frozen or exposed to temperatures outside the recommended storage range.
Contact customer support or a pharmacist if there are concerns about shipment condition, storage, or product handling after delivery.
Warnings and Precautions
Before Starting Zepbound
Before initiating treatment with Zepbound, it is important to have a comprehensive discussion with your healthcare provider. This conversation should encompass a thorough review of your medical history, current health status, and any medications or supplements you are currently taking. Here are some key points to consider:
- Medical History Disclosure: It’s crucial to share your complete medical history with your healthcare provider. Special attention should be given to any history of pancreas or kidney problems, as Zepbound can affect these organs.
- Severe Stomach Issues: If you have severe stomach problems, including gastroparesis (slow stomach emptying) or difficulty digesting food, discuss these with your doctor. Zepbound slows gastric emptying, which could exacerbate these conditions.
- Diabetic Retinopathy: Patients with a history of diabetic retinopathy should exercise caution. Inform your healthcare provider as Zepbound may have implications for this condition.
Pregnancy and Breastfeeding
- Pregnancy: Zepbound is not recommended during pregnancy. Weight loss during pregnancy can be harmful to the fetus. If you become pregnant while on Zepbound, discontinue use and contact your healthcare provider immediately.
- Breastfeeding: The safety of Zepbound during breastfeeding is not established. Discuss with your healthcare provider if you are breastfeeding or plan to breastfeed. They may advise on alternative feeding methods for your baby during treatment.
Thyroid Cancer Risk
- Boxed Warning: Zepbound carries a boxed warning about the potential risk of thyroid cancer. This is the most serious warning from the FDA. The active ingredient in Zepbound, tirzepatide, has been shown to cause thyroid tumors in animal studies.
- Family History of Thyroid Cancer: If you or any family member has had medullary thyroid carcinoma (MTC) or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), Zepbound should not be used due to the increased risk of thyroid cancer.
- Symptoms Monitoring: Be vigilant for symptoms of thyroid cancer, including a lump or swelling in the neck, hoarseness, difficulty swallowing, or shortness of breath. Report any such symptoms to your healthcare provider immediately.
Mental Health Considerations
- Depression and Suicidal Thoughts: If you have a history of depression or suicidal thoughts, it’s important to discuss this with your healthcare provider. Monitor any changes in mood or behavior and report them promptly.
Allergic Reactions
- Past Allergic Reactions: If you have had an allergic reaction to tirzepatide or any of the ingredients in Zepbound, avoid using this drug. Allergic reactions can be severe and require immediate medical attention.
Other Considerations
- Kidney Function Monitoring: Regular monitoring of kidney function is recommended, as Zepbound can affect kidney health, particularly in patients with pre-existing kidney conditions.
- Gastrointestinal Health: Zepbound may cause severe stomach problems. If you experience persistent or severe abdominal pain, nausea, or vomiting, contact your healthcare provider.
- Low Blood Sugar Risk: If used with other diabetes medications like insulin or sulfonylureas, Zepbound can increase the risk of hypoglycemia. Monitor blood sugar levels closely and report any instances of unusually low blood sugar.
General Precautions
- Regular Medical Reviews: Keep all scheduled appointments with your healthcare provider and undergo any recommended tests to monitor your body’s response to Zepbound.
- Lifestyle Modifications: While taking Zepbound, continue to follow any dietary and exercise recommendations made by your healthcare provider to maximize the medication’s effectiveness and minimize side effects.
These warnings and precautions are essential for the safe and effective use of Zepbound. Patients should have an open and ongoing dialogue with their healthcare providers to ensure they are using Zepbound appropriately and to monitor for any potential adverse effects or complications.
Drug Interactions
Understanding Interactions with Zepbound
Zepbound, due to its mechanism of action, can potentially interact with a variety of medications, supplements, and herbal products. These interactions can affect how Zepbound or the other medications work and may increase the risk of side effects.
Key Points on Drug Interactions
- Digestive System Impact: Zepbound slows down the digestive process, which can affect the absorption and effectiveness of other medications. This is particularly important for drugs that require rapid absorption or have a narrow therapeutic index.
- Medication Review: Provide your healthcare provider with a comprehensive list of all medications you are currently taking. This includes prescription drugs, over-the-counter medications, herbal supplements, and vitamins.
- Birth Control: Zepbound may reduce the effectiveness of birth control pills, potentially resulting in an unplanned pregnancy. Therefore, it is recommended to use an additional contraceptive method for four weeks after beginning Zepbound and for four weeks following each dose increase.
- Dosage Adjustments: Based on your medication list, your healthcare provider may adjust the dosages of your current medications or suggest alternative treatments to minimize interaction risks.
- Monitoring for Interactions: Regular monitoring may be necessary to check for any adverse interactions, especially when starting Zepbound or adding new medications to your regimen.
- Consultation with Pharmacist: In addition to your healthcare provider, consulting with a pharmacist can provide additional insights into potential drug interactions and how to manage them.
Contraindications
Zepbound should not be used by people with certain medical conditions. It is not suitable for anyone who has or has a family history of medullary thyroid cancer.
It should also not be used by people with multiple endocrine neoplasia syndrome type 2, a rare condition that affects hormone-producing glands. Those who have ever had thoughts of self-harm or suicidal behavior should avoid using it.
People who have shown allergic reactions or sensitivity to Zepbound or any of its ingredients should not take it. Always tell your doctor about your medical history before starting this treatment.
Alternative Medications
Exploring Options Beyond Zepbound
While Zepbound is an effective medication for weight loss, there are several other alternatives available in the market. Each of these medications has its unique mechanism of action and may be suitable for different individuals based on their health status, weight loss goals, and medical history.
Common Alternatives
- Mounjaro: Similar to Zepbound, Mounjaro contains tirzepatide and is used primarily for type 2 diabetes management but also shows effectiveness in weight loss.
- Semaglutide: Available under brand names like Ozempic and Wegovy, semaglutide is a GLP-1 receptor agonist used for both diabetes and weight loss.
- Phentermine: A well-known appetite suppressant, phentermine is used for short-term weight loss in conjunction with diet and exercise.
- Wegovy: Specifically approved for weight management, Wegovy is a higher dose of semaglutide and is used for chronic weight management.
- Saxenda: Another GLP-1 receptor agonist, Saxenda, is used for weight management in adults and has a different dosing regimen compared to Zepbound.
It’s important to consult with a healthcare provider to determine which medication is most suitable for your specific needs and weight loss goals.
Zepbound Price & Discounts
The cost of Zepbound can vary based on dose, pharmacy source, insurance coverage, and product availability. Some U.S. patients may look for lower available pricing through participating Canadian pharmacy partners.
Buy Canadian Insulin is a prescription-referral service that helps eligible customers access available prescription options through participating pharmacy partners. A valid prescription is required before any order can be reviewed and processed.
Prices may change based on supply, pharmacy availability, and exchange rates. Review the final price at checkout before placing your order.
| Strength | Quantity | Price (CAD) | Average USA Price | % Savings |
|---|---|---|---|---|
| 2.5 mg / 0.6 mL | 1 pen | $499.97 | $1,580 | 68% OFF |
| 5 mg / 0.6 mL | 1 pen | $499.97 | $1,580 | 68% OFF |
| 7.5 mg / 0.6 mL | 1 pen | $599.97 | $1,580 | 62% OFF |
| 10 mg / 0.6 mL | 1 pen | $599.97 | $1,580 | 62% OFF |
| 12.5 mg / 0.6 mL | 1 pen | $699.97 | $1,580 | 56% OFF |
| 15 mg / 0.6 mL | 1 pen | $699.97 | $1,580 | 56% OFF |
Coupon for Zepbound
Use coupon code ZEPBOUND10 at checkout to receive 10% off an eligible Zepbound order.
This offer may be subject to terms, availability, and order requirements. A valid prescription is required for prescription products.
Prescription & Pharmacy Information
A valid prescription from a licensed healthcare provider is required before Zepbound can be reviewed and dispensed through participating pharmacy partners.
Buy Canadian Insulin works with participating licensed pharmacy partners to help eligible customers submit prescription order requests. Prescription orders are reviewed before processing.
Pharmacist consultation may be available through participating pharmacy partners for medication-related questions, including administration, storage, possible side effects, and prescription review concerns.
Prescription orders may be dispensed by licensed pharmacy partners located in Canada or other approved international fulfillment locations, depending on product availability, prescription requirements, and pharmacy source.
For questions about prescription submission, order processing, product availability, or shipping, contact Buy Canadian Insulin customer support:
Phone: 1-888-525-1815
Fax: 1-888-234-1275
Email: info@buycanadianinsulin.com
Customer Support Hours:
Monday-Friday: 7 AM – 10 PM CST
Saturday & Sunday: 9 AM – 5 PM CST
Business Address:
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Selkirk, MB R1A 4M2
Canada
Frequently Asked Questions
Buying Zepbound from Canada
FDA-Prescription, Off-Label Information, and Limitations
Dosage & Administration
Adverse Reactions
Food & Drug Interactions
Storage & Travel
Drug Comparison
Disclaimer
Buy Canadian Insulin provides educational information about medications and health conditions for informational purposes only. This content is not intended to replace professional medical advice, diagnosis, or treatment. Prescription medications require valid prescription review and processing through participating pharmacy partners. Product availability, pricing, and shipping timelines may vary. Consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
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