Are you looking for alternatives to Wegovy pens for weight management? If you’re struggling with losing weight and considering medication, you may have heard of Wegovy (semaglutide) as a popular option. However, this medication may not be suitable for everyone due to cost, availability, or specific health concerns.

Fortunately, several alternatives to Wegovy are gaining attention in the medical community. In this article, we will explore different medications and natural supplements that offer similar benefits for weight control. You’ll get insights into how these alternatives work, their potential side effects, and how they compare effectiveness and cost to Wegovy.

So, if you’re curious about other options for weight management and want to learn more about Wegovy alternatives, keep reading.

Key Takeaways

  • Wegovy is an FDA-approved medication for chronic weight management in adults. It is effective in aiding weight loss and managing type 2 diabetes by enhancing glycemic control and reducing appetite. However, it is expensive, costing around $1,300 per month without insurance coverage.
  • Due to its high cost, potential side effects, and the requirement of being an injectable medication, alternatives like Saxenda, Zepbound (also known as Mounjaro), and Orlistat are considered by those seeking more affordable or different methods of administration for weight management.
  • Phentermine/Topiramate is highlighted as a cost-effective alternative, and it is noted for its significant weight loss results at a lower price point. However, it carries risks of serious side effects like heart issues and birth defects.
  • Tirzepatide, marketed under the brand names Zepbound and Mounjaro, offers a promising option for weight management. Clinical trials have proven its effectiveness, showing significant weight loss over 72 weeks. However, it is not suitable for individuals with certain medical histories.
  • Non-pharmaceutical alternatives such as dietary supplements and herbal remedies like PhenQ, green tea extract, and Garcinia Cambogia offer natural weight loss solutions. However, their efficacy and safety are not as extensively studied or validated as prescription medications.
  • The sister drug to Wegovy, Ozempic, shares the same active ingredient, semaglutide. Although it is primarily approved for managing type 2 diabetes, it also shows secondary benefits in weight loss, making it a potential off-label option for weight management.

wegovy (semaglutide)What Is Wegovy?

Wegovy (semaglutide) is an FDA-approved medication for chronic weight management in adults with obesity or overweight who have at least one weight-related condition, such as hypertension or type 2 diabetes. Wegovy, a glucagon-like peptide-1 (GLP-1) receptor agonist, has shown significant efficacy in promoting weight loss by enhancing glycemic control and reducing appetite. Clinical trials, particularly the Semaglutide Treatment Effect in People with Obesity (STEP) program, have demonstrated its superiority over placebo and other antidiabetic medications in weight reduction.

For example, in these trials, about 40% of participants on semaglutide achieved a weight loss of 5% or more. The cost of Wegovy can be high, potentially making it unaffordable unless covered by insurance. The price varies, but it can cost around $1,300 per month without insurance coverage. The effectiveness and relative safety of Wegovy, combined with its once-weekly dosing, offer a promising option for individuals struggling with weight issues and seeking medical intervention.

Wegovy Alternatives

Wegovy has gained attention due to its potential effectiveness in managing type 2 diabetes and aiding weight loss. However, there are several reasons why people might seek alternatives to Wegovy:

  • Cost: The out-of-pocket expenses for Wegovy can be unrealistic for some individuals, especially since no generic version of the medication is available.
  • Supply chain issues: High demand for Wegovy has led to shortages and supply chain challenges, making it difficult to obtain.
  • Contraindications: Wegovy is not recommended for people with a personal or family history of thyroid cancer or multiple endocrine neoplasia syndrome type 2 (MEN2). Additionally, its safety during pregnancy and breastfeeding is unclear.
  • Side effects: Some users experience headaches, stomach pain, nausea, vomiting, diarrhea, and constipation while using Wegovy, which may prompt them to seek alternatives.
  • Disinterest in injectable medications: Wegovy is administered via injection, and some people may prefer alternative forms of medication.

If you’re considering alternatives to Wegovy, here are some options to explore:

Buy Saxenda from CanadaLiraglutide (Saxenda)

Liraglutide, marketed under the brand name Saxenda, is a medication approved by the U.S. Food and Drug Administration (FDA) for chronic weight management among pediatric patients aged 12 and older who are obese, as well as in adults who meet certain body mass index (BMI) criteria. This medication works similarly to Wegovy (semaglutide) and can be a Wegovy alternative as both are part of a class of drugs called GLP-1 receptor agonists used for weight management.

Saxenda was evaluated in a 56-week clinical trial involving 251 patients aged 12 to 17. Participants were counseled on a reduced-calorie diet and increased physical activity for 12 weeks and then randomly assigned to receive Saxenda or a placebo daily. The primary measurement was the change in BMI standard deviation score (BMI SDS), which measures how an individual’s BMI compares to the average for their age and sex.

Patients treated with Saxenda showed an average reduction in their BMI SDS of 0.23, whereas those on placebo saw no change. Additionally, those on Saxenda lost an average of 2.65% of their body weight.

Pros

Cons

  • Effective in reducing BMI in adolescents
  • Assists in long-term weight management
  • Supports adult weight loss
  • Once-daily injection
  • It may cause gastrointestinal side effects
  • Risk of thyroid c-cell tumors (boxed warning)
  • Possible serious side effects like pancreatitis, gallbladder disease, and hypoglycemia
  • Includes risk of depression and suicidal thoughts
  • Requires continuous monitoring for several health conditions

Saxenda Cost

The average retail price in the United States is around $1,590 to $1,660 for a pack of 5 pre-filled pens. However, you can get this at Buy Canadian Insulin for a lower price. Saxenda is priced at $515.00 for a pack of five pre-filled pens (6mg/mL). To save on your purchase, you can utilize the coupon code “FIRST10” to receive a 10% discount on your first order, and additional savings are available for bulk purchases, such as up to a 90-day supply.

Zepbound (tirzepatide)Tirzepatide (Mounjaro/Zepbound)

Tirzepatide, sold under the brand name Zepbound, has recently been approved by the FDA as a treatment for chronic weight management in adults who are obese or overweight with at least one weight-related condition, such as high blood pressure, type 2 diabetes, or high cholesterol.

This medication, which is also known by another brand name, Mounjaro, for treating type 2 diabetes, helps to reduce appetite and food intake by activating certain hormone receptors. It is administered once weekly, gradually increasing to 15 mg per week. The effectiveness of Zepbound was proven in two major studies involving 2,519 patients, showing significant weight loss after 72 weeks compared to a placebo. For example, patients receiving the highest dosage of 15 mg lost an average of 18% of their body weight. Therefore, Zepbound and Mounjaro are good alternatives to Wegovy.

ProsCons
  • Significant weight loss proven in clinical trials
  • Administered only once a week
  • Reduces risk of cardiovascular diseases by aiding weight loss
  • It helps in managing weight in conjunction with diet and exercise
  • It may cause side effects like nausea, diarrhea, vomiting, and others
  • Not suitable for people with certain medical histories like medullary thyroid cancer
  • Long-term effects on humans unknown, particularly concerning thyroid C-cell tumors in rats
  • It cannot be used with other GLP-1 receptor agonists or certain medications for weight management

Tirzepatide (Mounjaro/Zepbound) Cost

Without insurance, the average monthly cost of Mounjaro in the United States is between $1,000 to $1,200. For Zepbound, the average cost is $1,000. Tirzepatide is available from Buy Canadian Insulin (Mounjaro) at a starting cost of $158.99 per vial, with additional savings available for bulk purchases. For instance, ordering three vials reduces the price to $467.97, offering a more cost-effective option for longer-term supply. First-time customers can also benefit from a 10% discount using the coupon code ‘FIRST10’.

Phentermine / Topiramate

Phentermine and topiramate are other Wegovy alternative medications approved by the FDA to help manage obesity in certain age groups, including youth. Phentermine is a medication that has been used for a long time and is approved for adolescents aged 16 and older with obesity. Topiramate, initially used for other conditions like epilepsy, is often prescribed off-label for obesity management.

When combined, these medications form phentermine/topiramate extended-release, which is also FDA-approved for chronic weight management in adults and children aged 12 and older.

Studies have shown that this combination can effectively help reduce weight. For instance, the combination has led to significant weight loss compared to a placebo, with patients losing an average of 7-8 kg throughout treatment.

ProsCons
  • Effective in reducing weight
  • Cost-effective compared to newer medications
  • Available for a broader age group (12 and older)
  • Improves several cardiometabolic outcomes
  • It can be used as a monotherapy or in combination
  • Potential side effects during the first months
  • Risk of serious side effects like heart issues
  • Teratogenic risk (risk of birth defects)
  • Not all insurance plans cover these medications
  • Requires careful monitoring for side effects

Phentermine / Topiramate Cost

The cost for a 30-day supply of phentermine/topiramate (3.75/23 mg) in the United States is approximately $160.

Xenical (orlistat)Orlistat (Xenical)

Orlistat is an FDA-approved medication for weight loss and another Wegovy alternative. Unlike Wegovy, which is a newer injection, Orlistat is taken orally. It works by inhibiting the enzymes that break down fats in your diet, which means less fat is absorbed by your body. Studies show that Orlistat can effectively reduce body weight.

For example, a study showed that combining Orlistat with a diet or exercise plan led to more weight loss than just dieting alone. About 44% of people taking Orlistat achieved a significant weight loss of 5% from their starting weight.

ProsCons
  • FDA-approved for safety
  • It can be taken orally
  • Helps reduce body weight
  • Widely accessible
  • It can cause gastrointestinal issues like diarrhea
  • May lead to deficiency in fat-soluble vitamins
  • Not suitable for pregnant or breastfeeding women
  • Requires diet modification for best results

Orlistat (Xenical) Cost

The average price in the United States for a 90-capsule supply of Xenical oral capsules with a strength of 120 mg is approximately $803.  Xenical is also available in a 120 mg dosage with 84 capsules for a lower price of $199.00 on the Buy Canadian Insulin. Customers can save on their first order by using the coupon code “FIRST10” to receive 10% off. Additionally, bulk order discounts are available for those purchasing up to a 90-day supply, offering further savings.

Contrave (Bupropion)Bupropion / Naltrexone (Contrave)

Bupropion/naltrexone is a combination medication approved by the FDA for weight management in adults with obesity or overweight with at least one weight-related condition such as high blood pressure, type 2 diabetes, or high cholesterol. The brand name for this medication is Contrave. It combines naltrexone, which is typically used for alcohol and opioid dependence, with bupropion, an antidepressant also used for smoking cessation.

Studies show that bupropion/naltrexone can lead to significant weight loss. For example, one study found that patients lost an average of 6.8% of their initial body weight after one year of treatment with the full dose of 32 mg naltrexone and 360 mg bupropion daily compared to those who took a placebo.

ProsCons
  • Promotes significant weight loss
  • Improves glycemic control in diabetics
  • Available as an oral tablet
  • Non-scheduled by the Drug Enforcement Administration
  • High attrition rates in studies
  • Common side effects like nausea and headache
  • Not for use in individuals with uncontrolled hypertension
  • Black box warning for potential increase in suicidal thoughts
  • Not suitable for patients with a history of seizure or eating disorders

Bupropion / Naltrexone (Contrave) Cost

The average price in the United States is $668 for a supply of 120 tablets 90mg/8mg. You can save big if you purchase Contrave at Buy Canadian Insulin for $444.58 (120 tabs) 90mg/8mg. To save on your first order, use the coupon code “FIRST10” to get 10% off.

Trulicity (Dulaglutide)Dulaglutide (Trulicity)

Dulaglutide, marketed under the brand name Trulicity, is a medication primarily used to improve blood sugar control in adults with type 2 diabetes. It belongs to a class of drugs known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs). Although dulaglutide effectively reduces weight as a side effect of its primary action on blood sugar levels, it is not currently explicitly FDA-approved for weight loss. The AWARD-11 trial, a notable study, demonstrated that higher doses of dulaglutide (3.0 mg and 4.5 mg) led to significant weight loss compared to a lower dose (1.5 mg). For instance, patients on the 4.5 mg dose experienced up to 5.0 kg of weight loss over 52 weeks.

ProsCons
  • Improves blood sugar control
  • Associated with weight loss
  • Low risk of hypoglycemia
  • It may reduce the risk of cardiovascular events
  • Not FDA-approved for weight loss
  • Potential gastrointestinal side effects like nausea, vomiting, and diarrhea
  • Requires weekly injections
  • It can be expensive without insurance

Dulaglutide (Trulicity) Cost

The list price of Trulicity in the United States is $977.42 per month. However, you can get this for $282.00 (4 pens) 0.75mg/0.5mL or 1.5mg/0.5mL at Buy Canadian Insulin. Customers can save on their first order using the coupon code FIRST10 to receive a 10% discount. Additionally, buying in bulk can provide further savings, especially since orders are limited to a 90-day supply.

Ozempic PensOzempic (semaglutide)

Ozempic is an injectable medication primarily used to improve blood sugar levels in adults with type 2 diabetes, and it also reduces the risk of major cardiovascular events like heart attack and stroke in those with known heart disease. Its active ingredient, semaglutide, is the same as that in Wegovy, but it is important to note that Ozempic itself is not FDA-approved specifically for weight loss.

However, weight loss has been observed as a secondary effect in Ozempic patients. In clinical studies, patients with type 2 diabetes treated with Ozempic experienced an average weight loss ranging from 8 to 14 pounds, depending on the dosage, compared to those on a placebo.

ProsCons
  • Effectively lowers blood sugar levels
  • Reduces risk of major cardiovascular events
  • A secondary benefit of weight loss observed in studies
  • Requires only once-weekly injection
  • Supported by substantial clinical data
  • Not FDA-approved specifically for weight loss
  • Serious side effects include potential thyroid tumors, pancreatitis, and gallbladder issues.
  • Common side effects include nausea, vomiting, and abdominal pain
  • Not suitable for type 1 diabetes or those with a history of certain thyroid cancers
  • Risk of dehydration due to possible gastrointestinal side effects

Ozempic Cost

The average cost of Ozempic in the United States is $1,029 for a supply of 1.5 milliliters. Ozempic is also available for purchase from Canadian sources at varying prices depending on the dosage and quantity of the injection pens. For example, the price starts at $429.96. To save on your purchase, you can use the coupon code “FIRST10” to receive a 10% discount on your first order.

Additionally, for even greater savings, consider these bulk pricing options for both Ozempic 2mg & 4mg pens available on our website:

  • 1 pen – $429.96
  • 2 pens – $849.98 ($424.99 per pen)
  • 3 pens – $1,259.97 ($419.99 per pen)
  • 4 pens – $1,659.96 ($414.99 per pen)
  • 5 pens – $2,049.95 ($409.99 per pen)
  • 6 pens – $2,429.94 ($404.99 per pen)

By ordering in bulk, you can enjoy a lower cost per pen, providing significant savings compared to purchasing individual units.

Byetta

Byetta, also known as exenatide, is a medication originally approved by the FDA to help manage blood sugar levels in adults with type 2 diabetes. Unlike Wegovy, which is specifically approved for weight loss, Byetta is not officially approved for weight loss purposes. However, it has shown potential benefits in reducing body weight as a secondary effect in various studies.

For instance, one study found that Byetta can lead to an average weight loss of about 2.8 kg over 30 weeks when used by individuals with type 2 diabetes. It works as a GLP-1 receptor agonist, mimicking a natural hormone in the body, helping slow digestion and decreasing appetite.

ProsCons
  • It helps in reducing blood sugar levels
  • It may promote weight loss as a secondary benefit
  • It may improve insulin sensitivity
  • It can be used alongside other diabetes medications
  • Not FDA-approved specifically for weight loss
  • Possible side effects include nausea, vomiting, and diarrhea
  • Requires injections, which might not be preferable for everyone
  • Risk of potentially serious complications like pancreatitis

Byetta Cost

The average cost in the United States is $905 for a supply of 2.4 milliliters.

Conclusion

While Wegovy offers effective weight management for individuals with obesity or overweight conditions, its high cost and side effects may lead some to seek alternatives. Several alternatives, including Liraglutide (Saxenda), Tirzepatide (Zepbound/Mounjaro), Phentermine/Topiramate, Orlistat (Xenical), and Bupropion/Naltrexone (Contrave), each with its own set of pros and cons. Among these, Phentermine/Topiramate and Orlistat are more cost-effective options. Additionally, natural alternatives like dietary fiber and green tea extract offer supportive benefits in weight management. Individuals must consider their health needs and potential side effects and consult healthcare professionals before choosing an alternative to Wegovy.

FAQs About Wegovy

Is there a generic for Wegovy?

As of now, Wegovy does not have a generic version available.

Is there a cheaper alternative to Wegovy?

More cost-effective alternatives to Wegovy include Saxenda, Zepbound, Mounjaro, Phentermine/Topiramate Extended-Release, Xenical, and Contrave. However, their effectiveness, potential side effects, and appropriateness should be evaluated individually. Additionally, availability and pricing can differ, so consulting with local pharmacies or healthcare providers is recommended.

What is the sister drug to Wegovy?

Ozempic and Wegovy, developed by Novo Nordisk, are injectable forms of semaglutide marketed under these brand names at different dosages. Additionally, Rybelsus is a related oral medication that contains semaglutide and is intended for treating type 2 diabetes.

Is Ozempic the same as Wegovy?

While Ozempic and Wegovy both contain semaglutide, their FDA approvals differ: Wegovy is approved for weight loss, and Ozempic is approved for treating type 2 diabetes. However, Ozempic may also be prescribed off-label for weight management and is available in different dosages.

Can I buy a Wegovy over the counter alternative?

Wegovy requires a prescription. Thus, no over-the-counter alternatives offer the same formulation. However, medications like Orlistat are available over the counter for weight loss.

Which is better, Wegovy or Mounjaro?

Mounjaro is typically used for treating Type 2 diabetes and may lead to more significant weight loss than Wegovy. However, more direct comparisons are necessary to verify this. Wegovy also provides cardiovascular benefits for individuals with heart disease, an advantage not yet confirmed for Mounjaro.

Is there an over-the-counter alternative to Wegovy?

Orlistat is one of the most accessible over-the-counter weight-loss medications if you seek an alternative to Wegovy.

Can I get Wegovy online?

Wegovy is available only with a prescription. You need to obtain a prescription from a licensed healthcare professional. You can purchase Wegovy from local pharmacies or reliable online platforms like Buy Canadian Insulin with a prescription.

Is there an oral form of Wegovy available?

Yes, there is an oral alternative to Wegovy. Rybelsus is an oral form of semaglutide, the active ingredient in Wegovy, but it’s only approved to treat type 2 diabetes. While Rybelsus can promote weight loss, studies show it’s less effective than Wegovy in this regard, with Rybelsus users averaging a loss of 10 pounds versus Wegovy’s 35-pound average.

Sources

Singh, G., Kushner, R. F., & Davies, M. (2022). Wegovy (semaglutide): A new weight loss drug for chronic weight management. PMC. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717485/

U.S. Food and Drug Administration. (2021, June 15). FDA approves weight management drug for patients aged 12 and older. https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-weight-management-drug-patients-aged-12-and-older

U.S. Food and Drug Administration. (2023, November 8). FDA approves new medication for chronic weight management. FDA. Retrieved from https://www.fda.gov/news-events/press-announcements/fda-approves-new-medication-chronic-weight-management

Kim, A., Nguyen, J., Babaei, M., Kim, A., Geller, D. H., & Vidmar, A. P. (2023). A narrative review: Phentermine and topiramate for the treatment of pediatric obesity. Adolescent Health, Medicine and Therapeutics, 14, 125-140.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460571/

Cureus. (2022). FDA-approved pharmacotherapy for weight loss over the last decade. PMC. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579826/

Yanovski, S. Z., & Yanovski, J. A. (2015). Naltrexone-Extended Release plus Bupropion-Extended Release for Treatment of Obesity. JAMA, 313(12), 1213–1214. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993523/

Bonora, E., Frias, J. P., Tinahones, F. J., et al. (2021). Effect of dulaglutide 3.0 and 4.5 mg on weight in patients with type 2 diabetes: Exploratory analyses of AWARD?11. Diabetes Obesity and Metabolism, 23(10), 2242-2250.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518850/

Novo Nordisk. (2023). What is Ozempic®? Ozempic® (semaglutide) injection. Retrieved from https://www.ozempic.com/why-ozempic/what-is-ozempic.html

Salehi, P., Hsu, I., Azen, C. G., Mittelman, S. D., Geffner, M. E., & Jeandron, D. (2017). Effects of Exenatide on Weight and Appetite in Overweight Adolescents and Young Adults with Prader-Willi Syndrome. Pediatric Obesity, 12(3), 221-228. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288290/