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Invokana (canagliflozin)

Starting from $164.99 (100mg/30 tabs)

Invokana
Canagliflozin
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Prescription Required.
Product of Canada.
Express Ships from Canada.

What is Invokana?

For those looking to buy Invokana, it’s important to understand its benefits and uses. Invokana, a trusted brand known by its generic name canagliflozin, is an oral antidiabetic medication manufactured by Janssen Pharmaceuticals. It has a few indications, including that it:

  • Improves glycemic control in adults with type 2 diabetes mellitus (T2DM) in addition to diet and exercise
  • Decreases the risk of serious cardiovascular events (e.g. death, myocardial infarction, stroke) in adults with T2DM and cardiovascular disease (CVD)
  • Decreases the risk of developing end-stage kidney disease (ESKD), serum creatinine doubling, death from cardiovascular causes, and hospitalization for heart failure in adults with T2DM and diabetic nephropathy with albuminuria over 300 mg/day

Controlling hyperglycemia prevents downstream complications such as kidney damage, loss of limbs, blindness, heart attack, stroke, or nerve problems. Cardiovascular and renal events in diabetes can also be detrimental. It is important that diabetes and related events remain controlled to lessen the chance of related complications. Invokana is not indicated for the treatment of type 1 diabetes. Invokana is available across various countries, offering a global solution for diabetes management.

How does Invokana work?

Invokana stands out in the treatment of type 2 diabetes as a sodium-glucose co-transporter 2 (SGLT2) inhibitor, a key difference from other diabetes medications. SGLT2 is a transporter in the kidneys responsible for reabsorbing filtered glucose. By inhibiting this transporter, Invokana effectively reduces the reabsorption of glucose in the kidneys, thereby lowering the renal glucose threshold. This action results in an increased excretion of glucose into the urine. Additionally, Invokana’s mechanism extends to preventing the SGLT2-dependent reabsorption of glucose and sodium, which in turn increases the sodium delivered to the distal tubule, enhancing tubuloglomerular feedback and reducing intraglomerular pressure. For optimal flexibility in diabetes management, patients can take their prescribed dose of Invokana either in the AM or PM, following their doctor’s advice.

Invokana Side Effects

This drug is an effective tool for controlling blood sugar in people with type 2 diabetes mellitus. However, like all medications, it may cause side effects. It’s important to be aware of these potential side effects and understand the toll they may take on your body to manage them effectively if they occur.

Common Side Effects:

  • Urinary tract infections
  • Increased urination
  • Yeast infections
  • Vaginal itching
  • Thirst
  • Constipation
  • Nausea
  • Fatigue
  • Weakness
  • Skin sensitivity to sunlight
  • Hypersensitivity reactions (including skin redness, rash, itching, hives, and swelling)
  • Bone fractures
  • Kidney problems

Serious Side Effects:

  • Swelling, hives, difficulty breathing, swelling of your tongue, mouth, or throat
  • Bloody or cloudy urine, decreased amount of urine, painful urination
  • Loss of appetite, back pain, pain during intercourse, unusual tiredness or weakness
  • Vaginal discharge, and weight gain
  • Serious eye symptoms (sudden vision loss, blurred vision, eye pain or swelling, seeing halos around lights)
  • Heart symptoms (fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; sudden dizziness, lightheadedness, or passing out)
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, very stiff muscles, high fever, profuse sweating, or tremors

Warning:

  • An approximately 2-fold increased risk of lower limb amputations has been observed in patients using Invokana. The most common amputations were those of the toe and midfoot; however, amputations involving the leg were also observed.

If you experience any of these side effects, especially the more serious ones, seek medical attention immediately. Always consult with your healthcare provider for more detailed information and guidance tailored to your specific health situation.

Warnings & Precautions

Lower Limb Amputation

In clinical trials, there was a higher risk of lower limb amputations in the group treated with Invokana compared to the group treated with placebo. This risk occurred at both the 100 mg and 300 mg doses. The most common amputations were those of the toe and midfoot, however, amputations of the leg also occurred. A few patients also had to undergo multiple amputations.

Patients with a history of previous amputation, peripheral vascular disease, diabetic foot ulcers, or neuropathy should use caution when starting Invokana. Patients should be counseled on preventative foot care and common signs of infection. If patients experience symptoms of infection, pain, ulcers, or sores in the lower limbs, Invokana should be stopped.

Volume Depletion

Invokana has been known to cause intravascular volume contraction which presents as hypotension or short-term changes to creatinine. Volume depletion has been shown to cause acute kidney injury (AKI) resulting in hospitalization and sometimes dialysis. Invokana should be used with caution in patients with eGFR of less than 60 mL/min/1.73 m2, elderly patients, or patients taking loop diuretics. These patients could have an elevated risk of developing hypotension and volume depletion. Providers should monitor patients for signs of volume depletion throughout treatment with Invokana.

Ketoacidosis

Invokana has been reported to cause ketoacidosis. Ketoacidosis is a severe, life-threatening event that needs immediate hospitalization and could be fatal. The risk of developing ketoacidosis is elevated with higher doses of SGLT2 inhibitors such as Invokana.

Patients with symptoms associated with metabolic acidosis should be evaluated for the possibility of ketoacidosis without regard to blood glucose levels. Ketoacidosis can still be present despite blood glucose levels less than 250 mg/dL. Symptoms include signs of dehydration and metabolic acidosis, such as vomiting, nausea, malaise, shortness of breath, and abdominal pain. If suspected, Invokana should be stopped, and the patient should be assessed and treated appropriately with insulin, carbohydrate replacement, and fluid.

A patient’s history should be evaluated prior to starting Invokana, as pancreatic insulin deficiency, caloric restriction, and alcohol abuse could predispose an individual to ketoacidosis. Patients undergoing surgery should stop Invokana 3 days prior to the surgery. If patients anticipate a clinical situation known to cause ketoacidosis, such as surgery or prolonged fasting, providers should consider stopping Invokana.

Urosepsis and Pyelonephritis

Invokana has caused cases of severe urinary tract infections involving urosepsis and pyelonephritis. Occurrences have sometimes required hospitalization. If a patient presents with signs of a urinary tract infection, they should be treated appropriately.

Hypoglycemia with Concomitant Use of Insulin Products

Invokana can cause hypoglycemia when used in combination with other products that lower blood glucose, such as insulin. Dose adjustments to insulin may be required to prevent development of hypoglycemia. Patients should be counseled on common signs and symptoms of hypoglycemia.

Necrotizing Fascilitis of the Perineum (Fournier’s Gangrene)

Necrotizing fasciitis of the perineum, also known as Fournier’s gangrene, is a rare but potentially fatal infection that requires immediate intervention with surgery. Occurrences can result in hospitalization, surgeries, and death. Patients should be aware of the signs and symptoms associated with necrotizing fasciitis, such as pain, erythema, tenderness, or swelling of the genital or perineal area. Symptoms can also include malaise or fever.

If necrotizing fasciitis is suspected, providers should treat with broad-spectrum antibiotics and possibly surgical debridement. Invokana should be stopped and blood glucose levels should be monitored.

Genital Mycotic Infections

Invokana has been shown to elevate the risk of genital mycotic infections. Patients who have had genital mycotic infections in the past or who are uncircumcised males have a higher likelihood of developing genital mycotic infections. If suspected, providers should monitor and treat the patient appropriately.

Hypersensitivity Reactions

Invokana has been shown to cause severe hypersensitivity reactions, including anaphylaxis and angioedema, within hours or days of starting therapy. If anaphylaxis or angioedema should occur, Invokana should be stopped and the patient should seek medical attention.

Bone Fracture

Patients have an elevated risk of bone fracture after starting Invokana. This risk can be increased as early as 12 weeks after starting treatment. Providers should assess a patient’s risk factors for developing a fracture before starting Invokana.

Drug Interactions

UGT Enzyme Inducers

UGT inducers include drugs such as rifampin, ritonavir, phenobarbital, and phenytoin. In patients who are on a UGT inducer and have an eGFR of less than 60 mL/min/1.73 m2, increase the dose of Invokana to 200 mg daily in those already tolerating 100 mg.

Digoxin

When co-administered with digoxin, Invokana has been shown to increase digoxin concentrations. Use caution when taking concomitantly and monitor appropriately to avoid digoxin toxicity.

Positive Urine Glucose Test

SGLT2 inhibitors such as Invokana can elevate glucose excretion in the urine. This phenomenon will cause positive urine glucose tests if administered. Therefore, do not use urine glucose tests to monitor glycemic control in patients taking Invokana.

Interference with 1,5-anhydroglucitol (1,5-AG) Assay

The 1,5-AG assay is not a reliable form of glycemic control monitoring in patients taking Invokana. Other methods should be implemented to monitor glucose control in patients taking SGLT2 inhibitors.

Medication Price & Coupons

Buy Invokana from Canada

For those looking to buy Invokana from Canada, significant cost savings can be realized. The cost of prescription medications can be a significant burden, especially in the United States where prices are often high. A prime example of this is the drug Invokana. In the U.S., the price for Invokana, particularly the 100mg dosage with 30 tablets, can exceed $750 for individuals without insurance coverage. This high price point can make it challenging for many patients to access the medication they need.

However, there is a cost-effective solution available through Canadian sources. By obtaining a prescription from a doctor, Americans can order Invokana online securely and conveniently from Canadian sources. At Buy Canadian Insulin (BCI), the price for the same drug – Invokana 100mg with 30 tablets – is significantly lower, available for only $164.99. This presents a substantial saving opportunity for those requiring this medication.

BCI operates as a prescription referral service. It serves as a bridge connecting U.S. patients with licensed pharmacies in Canada. The fulfillment process is streamlined for efficiency and reliability, ensuring that once an order is placed, a licensed pharmacy will promptly fulfill the prescription, maintaining the highest standards of quality and safety.

One of the key aspects of this service is the expedited shipping process. Once an order is placed, the drugs are express shipped to the United States, typically arriving within 3-5 business days. This quick turnaround time ensures that patients receive their order promptly, minimizing any potential disruption to their treatment plans. Once an order is placed, a licensed pharmacy will promptly fulfill the prescription, ensuring quality and safety.

Coupon Offer

To make this deal even more attractive, BCI offers a special discount for first-time customers. By using the coupon code FIRST10, new customers can save 10% on their first order. This additional discount further lowers the financial barrier, making essential medications like Invokana more accessible to those in need.

By choosing to order through BCI, patients in the U.S. can manage their health effectively while also making significant savings on their medication costs.

Frequently Asked Questions

Invokana (canagliflozin) is a prescription medication used to control blood sugar levels in adults with type 2 diabetes. It belongs to a class of drugs known as SGLT2 inhibitors, which work by helping the kidneys remove glucose from the bloodstream through urine.

Order Invokana at the lowest price, in various strengths and quantities to meet your specific needs. Here’s a quick overview of our current pricing:

  • For Invokana 100mg:
    • 30 tablets are priced at $164.99.
    • 60 tablets are available for $320.00.
    • 90 tablets can be purchased for $387.00.
  • For Invokana 300mg:
    • 30 tablets are priced at $169.99.
    • 60 tablets are available for $334.00.
    • 90 tablets can be purchased for $447.00.

Yes, Invokana can be used in combination with other diabetes medications, including insulin, to improve blood sugar control. However, it’s important to consult with a healthcare provider before starting or adjusting any medication regimen.

While both Invokana and Metformin are used to manage blood sugar levels in type 2 diabetes, they work in different ways. Metformin decreases glucose production in the liver and improves the body’s sensitivity to insulin. Invokana, on the other hand, works by blocking the reabsorption of glucose in the kidneys, leading to its excretion through urine.

Take Invokana exactly as your doctor tells you to take it. Typically, Invokana is taken once daily by mouth. It is best to take prior to your first meal of the day.

If you miss a dose, take it as soon as you remember. If it is time for the next dose at the time that you remember, skip the missed dose and return to your normal dosing schedule. Do not take more than one dose of Invokana at the same time.

Invokana can be taken with or without food.

If you overdose with Invokana, you should immediately go to the emergency room or contact the Poison Control Center.

Avoid excessive alcohol intake, as this increases one’s risk of developing ketoacidosis while on Invokana.

Common side effects include:

  • Yeast infections
  • Low blood sugar
  • Increased frequency and urgency in urination
  • Urinary tract infection
  • Allergic reaction
  • Low blood pressure

Serious side effects include:

  • Amputations
  • Dehydration
  • Increased ketones in your blood or urine
  • Broken bones
  • Serious bacterial infections of the skin

It is important that you tell your doctor all of the medications, vitamins, and supplements that you take, especially if you take:

  • Diuretics
  • Phenytoin or phenobarbital
  • Rifampin
  • Digoxin
  • Ritonavir

Additionally, tell your doctor if you:

  • Have a history of amputation
  • Have nerve damage in your leg
  • Have a history of urinary tract infections or urination problems
  • Have heart disease
  • Have a history of diabetic sores or foot ulcers
  • Have blocked blood vessels
  • Have kidney problems
  • Have liver problems
  • Are on a low sodium diet
  • Are undergoing surgery
  • Are starting a more restrictive diet
  • Have pancreas problems
  • Drink alcohol often or excessively
  • Are pregnant or plan to become pregnant
  • Are breastfeeding or plan to breastfeed

Store Invokana at room temperature between 68°F to 77°F (20°C to 25°C). It should be kept out of reach from children.

Weight loss can be a side effect of Invokana, primarily due to the excretion of glucose and associated calories in the urine. However, it should not be used as a weight-loss medication.

It begins to work soon after taking it, with its blood sugar-lowering effects noticeable within the first few weeks. However, the full benefits may take longer to realize, and it’s important to continue taking the medication as prescribed.

A balanced diet is an important part of managing type 2 diabetes. While taking Invokana, it’s advisable to maintain a diet that supports your diabetes management plan. Consult with a healthcare provider or dietitian for personalized advice.

Invokana is not approved for the treatment of type 1 diabetes. It is specifically designed for use in adults with type 2 diabetes.

Generic drugs offer the same active ingredients and efficacy as their brand-name counterparts, usually at a lower cost. As of now, a generic drug equivalent for Invokana, which contains the active ingredient canagliflozin, is not widely available on the market.