If you’ve been using Trulicity to manage your diabetes and are considering switching to Ozempic, you’re not alone. Studies show that about one-fourth of patients change from their first GLP-1 receptor agonist, like Trulicity, to a different treatment within a year. For many, this switch involves transitioning to another GLP-1 agent, such as Ozempic. It’s frustrating when you’re not sure if the new medication will work as well or how to transition without issues. The thought of adjusting dosages and dealing with new side effects adds extra stress, making the process seem challenging.

In this article, we’ll examine everything you need to know about switching from Trulicity to Ozempic. We’ll compare the effectiveness of the two medications for managing type 2 diabetes and weight loss, discuss the typical dosages and administration methods, and explore the potential side effects of each drug. 

Key Takeaways

  • When switching from Trulicity to Ozempic, the recommended approach is to wait one week after the last dose of Trulicity before starting Ozempic. This timing helps manage the transition without overlapping effects.
  • Ozempic is more effective than Trulicity in reducing A1C levels, a measure of average blood sugar levels over several months. Ozempic also helped more patients achieve their A1C goal of less than 7%.
  • Studies suggest that Ozempic may lead to greater weight loss compared to Trulicity. For instance, someone weighing 219 pounds might lose approximately 10-14 pounds with Ozempic, as opposed to 6-10 pounds with Trulicity.
  • Both medications are administered via subcutaneous injection once weekly, but there are differences in dosage options and the design of their injection pens. Ozempic pens are reusable with replaceable needles, whereas Trulicity pens are single-use only.
  • Before changing your medication, it’s important to discuss with your healthcare provider to understand if switching to Ozempic is appropriate based on your health needs and medical history.

Can You Switch from Trulicity to Ozempic?

Yes, you can switch from Trulicity to Ozempic, but you should decide with your doctor. Both medications work in similar ways to help manage blood sugar in people with type 2 diabetes. If you’re thinking about switching because your blood sugar isn’t well controlled or you’re having side effects from Trulicity, your doctor might consider it. However, they might also suggest adding a different medication instead of switching. 

According to a study, if you’re switching between two once-weekly GLP-1 receptor agonists, the recommended approach is to stop the current GLP-1 receptor agonist and start the new one week later, on the same day of the week. Talking to your doctor before changing your medication regimen is always important.

Comparing Trulicity and Ozempic Before Making A Switch

Trulicity and Ozempic are medications used to treat type 2 diabetes, but they work slightly differently. Trulicity contains dulaglutide, a type of medication called a GLP-1 receptor agonist. Ozempic contains semaglutide, which is also a GLP-1 receptor agonist. These medications help the body release insulin and lower blood sugar levels after eating, which helps to control diabetes.

Now, let’s look at how effective they are in treating diabetes. In a study called SUSTAIN 7, researchers compared Ozempic and Trulicity head-to-head. They found that Ozempic was better at reducing A1C levels than Trulicity. A1C is a measure of average blood sugar levels over the past few months. In the study, Ozempic reduced A1C levels more than Trulicity did. For example, Ozempic reduced A1C by 1.5%, while Trulicity only reduced it by 1%. This means that Ozempic was more effective at helping people control their blood sugar levels.

Not only that, but Ozempic also helped more people reach their A1C goal of less than 7%. About three out of four people who took Ozempic achieved this goal, compared to fewer people who took Trulicity.

Ozempic vs Trulicity for Weight Loss

Several studies provide insights when comparing Ozempic and Trulicity for weight loss. One found that Ozempic resulted in a weight loss of about 4-5.48% from the initial weight. This means that if someone weighs 219 pounds, they might lose around 10-14 pounds

On the other hand, Trulicity showed a weight loss of about 4-5%. That’s roughly 6-10 pounds for someone weighing 200 pounds. So, Ozempic seems to be more effective in promoting weight loss than Trulicity. These results suggest that Ozempic might be a better choice for individuals looking to manage their weight while also addressing diabetes.

Trulicity vs Ozempic Dosage

The dosage of Trulicity and Ozempic may differ based on various factors, including individual response to treatment, medical history, and other medications being taken. Here’s a breakdown of the typical dosage for each:

Ozempic Dosage

Form: Subcutaneous injection


  • 2 mg/3 mL
  • 4 mg/3 mL
  • 8 mg/3 mL


  • 0.5 mg
  • 1 mg
  • 2 mg

Frequency: Once weekly

Administration: Ozempic injection pens come with disposable, single-use needles. A new needle must be attached to the pen each time you administer a dose. The dose selector on the pen allows you to select your dose. The number of doses you can get from each pen depends on your dose and the strength of your pen.

Trulicity Dosage

Form: Subcutaneous injection


  • 0.75 mg/0.5 mL
  • 1.5 mg/0.5 mL
  • 3 mg/0.5 mL
  • 4.5 mg/0.5 mL


  • 0.75 mg
  • 1.5 mg
  • 3 mg
  • 4.5 mg

Frequency: Once weekly

Administration: Trulicity injection pens come with a needle already attached. Each pen is for single use only and delivers one dose of medication. You use a new pen each time you administer a dose.

Both drugs are given once weekly and are self-administered. The main differences are in the available strengths and the specific administration details, such as the reusability of Ozempic pens versus the single-use nature of Trulicity pens.

Trulicity vs Ozempic Side Effects

Side EffectsOzempicTrulicity
Mild Side Effects  
Flatulence (gas)
Abdominal pain
Upset stomach
Decreased appetite
Mild allergic reaction
Serious Side Effects  
Risk of thyroid cancer
Kidney damage
Diabetic retinopathy
Gallbladder disease
Severe gastrointestinal issues
Severe allergic reaction

Note: An allergic reaction is possible after using both Ozempic and Trulicity. This side effect wasn’t reported in clinical trials but has occurred since both drugs were approved. Severe allergic reactions include symptoms like swelling of the face, lips, tongue, or throat, which may cause difficulty breathing.

Which is More Affordable – Trulicity or Ozempic?

MedicationUS Price (Average for a 4-week supply)Buy Canadian Insulin Discount Price
TrulicityOver $1,000Prices start at as low as $282 for a pack containing four pens, and they are available in 0.75mg/0.5mL and 1.5mg/0.5mL dosages. 
OzempicOver $1,000Prices start at $429.96 for a single pen of 2mg/3mL or 4mg/3mL. The higher dosages of Ozempic, like 1mg/1.5mL to 9.6mg/3mL, are priced at $609.99 per pen.

Note: First-time buyers from Buy Canadian Insulin can benefit from a 10% discount on their first order using the coupon code “FIRST10.” This and potential savings from bulk orders (limited to a 90-day supply). 

Things to Keep in Mind When Switching from Trulicity to Ozempic

When considering a switch from Trulicity to Ozempic, there are several key points to keep in mind:

  • Consult Your Doctor: Always discuss with your healthcare provider before changing your medication. Your doctor can help you understand if switching to Ozempic is appropriate based on your health needs and medical history.
  • Medication Differences: Although Ozempic and Trulicity are glucagon-like peptide-1 (GLP-1) agonists used to manage type 2 diabetes, they contain different active ingredients and may work slightly differently in your body. It’s important to understand how these differences might affect you.
  • Administration: Both drugs are administered through injection, but Ozempic pens allow for multiple uses with replaceable needles, whereas Trulicity pens are for single use only. Ensure you understand how to use the Ozempic injection pen properly.
  • Side Effects: Be aware of potential side effects. Both medications have similar side effect profiles, including risks of thyroid cancer, pancreatitis, and gastrointestinal issues. However, individual reactions can vary, so monitor your health closely after switching.
  • Effectiveness: Clinical studies suggest that Ozempic may offer stronger blood sugar management effectiveness than Trulicity. Discuss with your doctor whether this potential increased effectiveness is a factor in considering the switch.
  • Insurance Coverage: Check with your insurance provider, as coverage and out-of-pocket costs for Ozempic might differ from those for Trulicity, which can impact your decision.
  • Transition Phase: If you switch, your body may adjust to the new medication during a transition phase. Follow your doctor’s instructions regarding dosing schedules to avoid any gaps or overlaps in medication.

Final Thoughts

Switching from Trulicity to Ozempic can be a beneficial move for individuals with type 2 diabetes, particularly if they are experiencing side effects or struggling to control their blood sugar levels. While both drugs work in similar ways, Ozempic has been shown to be more effective in reducing A1C levels and promoting weight loss. 

However, it’s essential to discuss the switch with a doctor to determine if it’s the right choice for you. Additionally, it’s crucial to follow the recommended approach for transitioning from one drug to the other to manage the change effectively and minimize any potential side effects. With proper guidance and monitoring, individuals can make an informed decision and smoothly switch to Ozempic from Trulicity.

FAQs About Trulicity And Ozempic

Can Ozempic and Trulicity be taken together?

No, Ozempic and Trulicity should not be used together. They work in the same way to treat diabetes and lower the risk of certain heart problems, so combining the two drugs will not benefit your condition.

Is Ozempic the same as Trulicity?

Ozempic and Trulicity are two medications that are quite similar, but there are some differences between them. While both are administered through pens, some people may find Trulicity pens easier to use than Ozempic pens. It is important to note that Trulicity can sometimes cause serious side effects in your stomach or intestines, which is not the case with Ozempic.

Which is better, Trulicity or Ozempic?

According to the study, Ozempic may work slightly better than Trulicity. However, real-world data suggests that people are more likely to stick to their prescribed Trulicity regimen and are less likely to stop taking it.

What are the available alternatives for Trulicity?

The following are the alternatives for Trulicity:

  • Victoza
  • Semaglutide
  • Rybelsus
  • Januvia
  • Byetta
  • Mounjaro
  • Tirzepatide
  • Dulaglutide
  • Adlyxin
  • Bydureon BCise
  • Metformin

What are the available alternatives for Ozempic?

Alternatives for Type 2 diabetes may include Rybelsus, Trulicity, or Mounjaro. If using Ozempic off-label for weight loss, FDA-approved options include Wegovy and Saxenda.

How long does Trulicity stay in your system?

Trulicity has a half-life of approximately 5 days. This means it takes roughly 5 days for your body to eliminate half of a dose of Trulicity. Generally, a drug takes around 5 half-lives to exit your system. Therefore, Trulicity will be present in your body for roughly 25 days after your last dose.

What happens if you suddenly stop Trulicity?

If you suddenly stop taking Trulicity, you will not experience withdrawal symptoms, but your glycemic control may worsen. Therefore, speaking with your doctor about how to stop taking Trulicity safely is essential.

How to switch from Trulicity to Ozempic?

Your doctor will likely recommend waiting one week after your last dose of Trulicity before starting treatment with Ozempic.


Novo Nordisk. (2023). Ozempic® vs. Trulicity®: SUSTAIN 7 Clinical Trial. Retrieved from https://www.novomedlink.com/diabetes/products/treatments/ozempic/efficacy-safety/ozempic-vs-trulicity.html

Almandoz, J. P., Lingvay, I., Morales, J., & Campos, C. (2020). Switching Between Glucagon-Like Peptide-1 Receptor Agonists: Rationale and Practical Guidance. Clin Diabetes, 38(4), 390–402.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566932/

Novo Nordisk. (2023, September). What is Ozempic®? Retrieved from https://www.ozempic.com/why-ozempic/what-is-ozempic.html

National Center for Biotechnology Information. Effect of dulaglutide 3.0 and 4.5 mg on weight in patients with type 2 diabetes: Exploratory analyses of AWARD-11. PubMed Central. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518850/