If you’ve been using Trulicity to manage your diabetes and are considering switching to Ozempic, you’re not alone. Studies show that about one-fourth of patients change from their first GLP-1 receptor agonist, like Trulicity, to a different treatment within a year. For many, this switch involves transitioning to another GLP-1 agent, such as Ozempic. It’s frustrating when you’re not sure if the new medication will work as well or how to transition without issues. The thought of adjusting dosages and dealing with new side effects adds extra stress, making the process seem challenging.
In this article, we’ll examine everything you need to know about switching from Trulicity to Ozempic. We’ll compare the effectiveness of the two medications for managing type 2 diabetes and weight loss, discuss the typical dosages and administration methods, and explore the potential side effects of each drug.
Can You Switch from Trulicity to Ozempic?
Yes, you can switch from Trulicity to Ozempic. Both medications work in similar ways to help manage blood sugar in people with type 2 diabetes. If you’re thinking about switching because your blood sugar isn’t well controlled or you’re having side effects from Trulicity, your doctor might consider it. However, they might also suggest adding a different medication instead of switching. According to a study, if you’re switching between two once-weekly GLP-1 receptor agonists, the recommended approach is to stop the current GLP-1 receptor agonist and start the new one week later, on the same day of the week.
Comparing Trulicity and Ozempic Before Making A Switch
Trulicity and Ozempic are medications used to treat type 2 diabetes, but they work slightly differently. Trulicity contains dulaglutide, a type of medication called a GLP-1 receptor agonist. Ozempic contains semaglutide, which is also a GLP-1 receptor agonist. These medications help the body release insulin and lower blood sugar levels after eating, which helps to control diabetes.
Now, let’s look at how effective they are in treating diabetes. In a study called SUSTAIN 7, researchers compared Ozempic and Trulicity head-to-head. They found that Ozempic was better at reducing A1C levels than Trulicity. A1C is a measure of average blood sugar levels over the past few months. In the study, Ozempic reduced A1C levels more than Trulicity did. For example, Ozempic reduced A1C by 1.5%, while Trulicity only reduced it by 1%. This means that Ozempic was more effective at helping people control their blood sugar levels.
Not only that, but Ozempic also helped more people reach their A1C goal of less than 7%. About three out of four people who took Ozempic achieved this goal, compared to fewer people who took Trulicity.
Ozempic vs Trulicity for Weight Loss
Several studies provide insights when comparing Ozempic and Trulicity for weight loss. One found that Ozempic resulted in a weight loss of about 4-5.48% from the initial weight. This means that if someone weighs 219 pounds, they might lose around 10-14 pounds.
On the other hand, Trulicity showed a weight loss of about 4-5%. That’s roughly 6-10 pounds for someone weighing 200 pounds. So, Ozempic seems to be more effective in promoting weight loss than Trulicity. These results suggest that Ozempic might be a better choice for individuals looking to manage their weight while also addressing diabetes.
Trulicity vs Ozempic Dosage
The dosage of Trulicity and Ozempic may differ based on various factors, including individual response to treatment, medical history, and other medications being taken. Here’s a breakdown of the typical dosage for each:
Ozempic Dosage
Form: Subcutaneous injection
Strengths:
- 2 mg/3 mL
- 4 mg/3 mL
- 8 mg/3 mL
Doses:
- 0.5 mg
- 1 mg
- 2 mg
Frequency: Once weekly
Administration: Ozempic injection pens come with disposable, single-use needles. A new needle must be attached to the pen each time you administer a dose. The dose selector on the pen allows you to select your dose. The number of doses you can get from each pen depends on your dose and the strength of your pen.
Trulicity Dosage
Form: Subcutaneous injection
Strengths:
- 0.75 mg/0.5 mL
- 1.5 mg/0.5 mL
- 3 mg/0.5 mL
- 4.5 mg/0.5 mL
Doses:
- 0.75 mg
- 1.5 mg
- 3 mg
- 4.5 mg
Frequency: Once weekly
Administration: Trulicity injection pens come with a needle already attached. Each pen is for single use only and delivers one dose of medication. You use a new pen each time you administer a dose.
Both drugs are given once weekly and are self-administered. The main differences are in the available strengths and the specific administration details, such as the reusability of Ozempic pens versus the single-use nature of Trulicity pens.
Trulicity vs Ozempic Side Effects
| Side Effects | Ozempic | Trulicity |
| Mild Side Effects | ||
| Fatigue | ||
| Nausea | ||
| Vomiting | ||
| Diarrhea | ||
| Constipation | ||
| Flatulence (gas) | ||
| Abdominal pain | ||
| Upset stomach | ||
| Decreased appetite | ||
| Mild allergic reaction | ||
| Serious Side Effects | ||
| Risk of thyroid cancer | ||
| Pancreatitis | ||
| Hypoglycemia | ||
| Kidney damage | ||
| Diabetic retinopathy | ||
| Gallbladder disease | ||
| Severe gastrointestinal issues | ||
| Severe allergic reaction |
Note: An allergic reaction is possible after using both Ozempic and Trulicity. This side effect wasn’t reported in clinical trials but has occurred since both drugs were approved. Severe allergic reactions include symptoms like swelling of the face, lips, tongue, or throat, which may cause difficulty breathing.
Which is More Affordable – Trulicity or Ozempic?
| Medication | US Price (Average for a 4-week supply) | Buy Canadian Insulin Discount Price |
| Trulicity | Over $1,000 | Prices start as low as $282 for a Trulicity box containing four pens, and they are available in 0.75mg/0.5mL and 1.5mg/0.5mL dosages. |
| Ozempic | Over $1,000 | Prices start at $329.95 for a single Ozempic pen of 2mg/3mL or 4mg/3mL. |
Note: First-time buyers from Buy Canadian Insulin can benefit from a 10% discount on their first order using the coupon code “FIRST10.” This and potential savings from bulk orders (limited to a 90-day supply).
Things to Keep in Mind When Switching from Trulicity to Ozempic
When considering a switch from Trulicity to Ozempic, there are several key points to keep in mind:
- Consult Your Doctor: Always discuss with your doctor before changing your medication. Your doctor can help you understand if switching to Ozempic is appropriate based on your health needs and medical history.
- Medication Differences: Although Ozempic and Trulicity are glucagon-like peptide-1 (GLP-1) agonists used to manage type 2 diabetes, they contain different active ingredients and may work slightly differently in your body. It’s important to understand how these differences might affect you.
- Administration: Both drugs are administered through injection, but Ozempic pens allow for multiple uses with replaceable needles, whereas Trulicity pens are for single use only. Ensure you understand how to use the Ozempic injection pen properly.
- Side Effects: Be aware of potential side effects. Both medications have similar side effect profiles, including risks of thyroid cancer, pancreatitis, and gastrointestinal issues. However, individual reactions can vary, so monitor your health closely after switching.
- Effectiveness: Studies suggest that Ozempic may offer better blood sugar control than Trulicity. Consider whether this potential increased effectiveness is important for you.
- Insurance Coverage: Check with your insurance provider, as coverage and out-of-pocket costs for Ozempic might differ from those for Trulicity, which can impact your decision.
Transition Phase: When switching, your body may need time to adjust to the new medication. Follow dosing schedules carefully to avoid any gaps or overlaps in medication.
Final Thoughts
Switching from Trulicity to Ozempic can be beneficial, especially for those looking to achieve better weight loss results. Ozempic has shown more significant weight loss effects and might offer more cost savings. When making the switch, start with the recommended dosage of Ozempic and monitor your body’s response. Be aware of the potential side effects, such as nausea and gastrointestinal issues, which might be more prominent with Ozempic.
Frequently Asked Questions
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Sources
Novo Nordisk. (2023). Ozempic® vs. Trulicity®: SUSTAIN 7 Clinical Trial. Retrieved from https://www.novomedlink.com/diabetes/products/treatments/ozempic/efficacy-safety/ozempic-vs-trulicity.html
Almandoz, J. P., Lingvay, I., Morales, J., & Campos, C. (2020). Switching Between Glucagon-Like Peptide-1 Receptor Agonists: Rationale and Practical Guidance. Clin Diabetes, 38(4), 390–402.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566932/
Novo Nordisk. (2023, September). What is Ozempic®? Retrieved from https://www.ozempic.com/why-ozempic/what-is-ozempic.html
National Center for Biotechnology Information. Effect of dulaglutide 3.0 and 4.5 mg on weight in patients with type 2 diabetes: Exploratory analyses of AWARD-11. PubMed Central. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518850/




